Role of Na+/H+ exchange by interferon-gamma in enhanced expression of JE and I-A beta genes   总被引：6，自引：0，他引：6  

V Prpic  S F Yu  F Figueiredo  P W Hollenbach  G Gawdi  B Herman  R J Uhing  D O Adams 《Science (New York, N.Y.)》1989,244(4903):469-471

The rapid transductional sequences initiated by interferon-gamma (IFN-gamma) on binding to its receptor regulate functional and genomic responses in many cells but are not well defined. Induction of macrophage activation is an example of such functional and genomic changes in response to IFN-gamma. Addition of IFN-gamma to murine macrophages, at activating concentrations, produced rapid (within 60 seconds) alkalinization of the cytosol and a concomitant, rapid influx of 22Na+. Amiloride inhibited the ion fluxes and the accumulation of specific messenger RNA for two genes induced by IFN-gamma (the early gene JE and the beta chain of the class II major histocompatibility complex gene I-A). The data indicate that IFN-gamma initiates rapid exchange of Na+ and H+ by means of the Na+/H+ antiporter and that these amiloride-sensitive ion fluxes are important to some of the genomic effects of IFN-gamma.  相似文献   

Archeological Research Strategies: Past and Present: Current goals, methods, and structure of throught approach more closely those of the natural sciences     

Adams RM 《Science (New York, N.Y.)》1968,160(3833):1187-1192

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Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22     

Adams EJ  Chien YH  Garcia KC 《Science (New York, N.Y.)》2005,308(5719):227-231

Gammadelta T cell receptors (TCRs), alphabeta TCRs, and antibodies are the three lineages of somatically recombined antigen receptors. The structural basis for ligand recognition is well defined for alphabeta TCR and antibodies but is lacking for gammadelta TCRs. We present the 3.4 A structure of the murine gammadelta TCR G8 bound to its major histocompatibility complex (MHC) class Ib ligand, T22. G8 predominantly uses germline-encoded residues of its delta chain complementarity-determining region 3 (CDR3) loop to bind T22 in an orientation substantially different from that seen in alphabeta TCR/peptide-MHC. That junctionally encoded G8 residues play an ancillary role in binding suggests a fusion of innate and adaptive recognition strategies.  相似文献   

Radar mapping, archeology, and ancient maya land use     

Adams RE  Brown WE  Culbert TP 《Science (New York, N.Y.)》1981,213(4515):1457-1468

A severe incongruity has long existed between the well-known complexity of ancient Maya civilization and the relatively feeble economic base that could be reconstructed for it. Recent fieldwork has ihdicated that much more intensive cultivation patterns were used than was previously thought. Data from the use of synthetic aperture radar in aerial surveys of the southern Maya lowlands suggest that large areas were drained by ancient canals that may have been used for intensive cultivation. Ground checks in several limited areas have confirmed the existence of canals, and excavations and ground surveys have provided valuable comparative information. Taken together, the new data suggest that Late Class period Maya civilization was firmly grounded in large-scale and intensive cultivation of swampy zones.  相似文献   

Autoradiography of Volcanic Rocks of Mount Lassen     

Rogers JJ  Adams JA 《Science (New York, N.Y.)》1957,125(3258):1150

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Adjustments in University Plans and Programs to Meet Long-Range Needs     

Adams AS 《Science (New York, N.Y.)》1948,107(2781):384-386

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Biologically active compounds in orchid fragrances     

Dodson CH  Dressler RL  Hills HG  Adams RM  Williams NH 《Science (New York, N.Y.)》1969,164(3885):1243-1249

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Microcolonial fungi: common inhabitants on desert rocks?     

Staley JT  Palmer F  Adams JB 《Science (New York, N.Y.)》1982,215(4536):1093-1095

Microcolonial structures have been harvested from desert rock samples for cultivation and ultrastructural examination. The results indicate that these microcolonial structures are fungi previously unrecognized as inhabitants of desert rocks.  相似文献   

Science, technology, and some dilemmas of advocacy     

Adams M 《Science (New York, N.Y.)》1973,180(4088):840-842

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Radiation in the Natural Environment     

Adams JA  Lowder WM 《Science (New York, N.Y.)》1963,141(3578):365-366

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