Naturally occurring trypanosomiasis (Chagas' disease) in dogs.     

G D Williams  L G Adams  R G Yaeger  R K McGrath  W K Read  W R Bilderback 《Journal of the American Veterinary Medical Association》1977,171(2):171-177

Nine fatal cases of canine American trypanosomiasis (Chagas' disease) were encountered from November, 1972, through November, 1975. Of the 9 cases, 7 occurred in dogs from 5 central Texas counties, and all but one case was diagnosed during the months of September, October, or November. The source of infection was discovered in only one case--that being a doghouse heavily infested with Triatoma lectularius occulta. Each of 6 bugs collected had infective forms of the protozoan, Trypanosoma cruzi. Trypanosomiasis usually is not considered in the differential clinical diagnosis of cardiac dysfunction in man or other mammals in the United States. An antemortem diagnosis was made in only 1 of the 9 dogs, with diagnosis in the remaining dogs being made at necropsy. The predominant microscopic lesion in all dogs was necrotizing granulomatous myocarditis associated with the amastigotes of T cruzi.  相似文献   

Die Fortbewegung der Spermien im weiblichen Genitaltrakt und ihre Beziehungen zur Fruchtbarkeit*     

Von C. E. Adams 《Reproduction in domestic animals》1969,4(2):49-56

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THE DURATION OF THE OESTROUS CYCLE OF EWES AFFECTED WITH CLOVER DISEASE     

N. R. Adams B.V.Sc.  Ph.D.  R. J. Lightfoot B.Sc.Agric.  Ph.D.  A. J. Charlick 《Australian veterinary journal》1975,51(6):306-309

Oestrous cycles in ewes affected with clover disease were compared with those for control animals at two locations. Significantly fewer diseased ewes were observed in oestrus. There was a significant increase in variability of oestrous cycle duration in the diseased ewes at one location. Some of the cycle irregularities could be related to gross lesions in the internal genitalia. Despite these findings, there was no association between oestrous cycle abnormalities and previous fertility records, suggesting that they are of little consequence to the infertility of clover disease under field conditions.  相似文献   

New perspectives in circulatory shock: pathophysiologic mediators of the mammalian response to endotoxemia and sepsis.     

E M Green  H R Adams 《Journal of the American Veterinary Medical Association》1992,200(12):1834-1841

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Pharmacodynamic actions of antimicrobial agents in host cell membranes     

H R Adams 《Journal of the American Veterinary Medical Association》1984,185(10):1127-1130

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Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response     

Liu PT  Stenger S  Li H  Wenzel L  Tan BH  Krutzik SR  Ochoa MT  Schauber J  Wu K  Meinken C  Kamen DL  Wagner M  Bals R  Steinmeyer A  Zügel U  Gallo RL  Eisenberg D  Hewison M  Hollis BW  Adams JS  Bloom BR  Modlin RL 《Science (New York, N.Y.)》2006,311(5768):1770-1773

In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-regulated expression of the vitamin D receptor and the vitamin D-1-hydroxylase genes, leading to induction of the antimicrobial peptide cathelicidin and killing of intracellular Mycobacterium tuberculosis. We also observed that sera from African-American individuals, known to have increased susceptibility to tuberculosis, had low 25-hydroxyvitamin D and were inefficient in supporting cathelicidin messenger RNA induction. These data support a link between TLRs and vitamin D-mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection.  相似文献   

Canine limbal melanoma: 30 cases (1992-2004). Part 1. Signalment, clinical and histological features and pedigree analysis     

Donaldson D  Sansom J  Scase T  Adams V  Mellersh C 《Veterinary ophthalmology》2006,9(2):115-119

OBJECTIVES: (1) To review the signalment, clinical, and histological features of canine limbal melanoma; (2) to perform pedigree analysis on breeds predisposed to limbal melanoma to establish if common ancestry exists; and (3) to investigate if any ancestral relationship exists between canine limbal melanoma and canine anterior uveal melanoma (CAUM). DESIGN: Retrospective study. ANIMALS STUDIED: Thirty dogs with limbal melanoma. METHODS: Medical records of patients were reviewed. Follow-up information was obtained by re-examination of patients or telecommunications with the referring veterinary surgeons or the owners. Pedigrees were analyzed for common ancestry amongst affected dogs. RESULTS The mean age (+/- SD) at diagnosis was 6.2 (+/- 2.75) years with a range from 1 to 11 years. There was a bimodal distribution of ages with a peak at 3-4 years and a peak at 7-10 years. There was no eye predilection or predisposition for sex or coat color. Twenty-five (83%) of the limbal melanomas occurred within a dorsal arc from the dorsomedial to the ventrolateral limbus. Golden retrievers were four times more common in the melanoma group compared to the Animal Health Trust population (P < 0.0001). Labrador retrievers were three times more common in the melanoma group (P=0.01). Pedigree analysis on eight Golden retrievers [limbal melanoma (n=5), CAUM (n=2) and diffuse ocular melanosis (n=1)], revealed a pattern of inter-relatedness consistent with the condition(s) being caused, at least in part, by a genetic mutation(s). A similar level of inter relatedness was evident in six Labrador retrievers (limbal melanoma (n=2) and CAUM (n=4)). In 5/22 cases (23%), histological features suggestive of malignancy were present including intratumor necrosis in 4/22 cases (18%) and cellular atypia in 1/22 cases (5%). CONCLUSIONS: In Golden and Labrador retrievers there is evidence that limbal melanomas, CAUM and ocular melanosis are at least in part heritable and that the same genetic mutation(s) may be causally associated with melanocytic disease at different ocular sites. The same genetic mutation(s) may be present in these two breeds. Histology should be performed on all cases to identify those with greater malignant potential.  相似文献   

Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells     

Mora JR  Iwata M  Eksteen B  Song SY  Junt T  Senman B  Otipoby KL  Yokota A  Takeuchi H  Ricciardi-Castagnoli P  Rajewsky K  Adams DH  von Andrian UH 《Science (New York, N.Y.)》2006,314(5802):1157-1160

Normal intestinal mucosa contains abundant immunoglobulin A (IgA)-secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT). We show that dendritic cells (DC) from GALT induce T cell-independent expression of IgA and gut-homing receptors on B cells. GALT-DC-derived retinoic acid (RA) alone conferred gut tropism but could not promote IgA secretion. However, RA potently synergized with GALT-DC-derived interleukin-6 (IL-6) or IL-5 to induce IgA secretion. Consequently, mice deficient in the RA precursor vitamin A lacked IgA-secreting cells in the small intestine. Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effector activity through synergistically acting mediators.  相似文献   

Individual cell migration serves as the driving force for optic vesicle evagination     

Rembold M  Loosli F  Adams RJ  Wittbrodt J 《Science (New York, N.Y.)》2006,313(5790):1130-1134

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Spontaneous retrograde movement of ureteroliths in two dogs and five cats     

Dalby AM  Adams LG  Salisbury SK  Blevins WE 《Journal of the American Veterinary Medical Association》2006,229(7):1118-1121

CASE DESCRIPTION: 2 dogs and 5 cats were evaluated for treatment of ureteroliths. CLINICAL FINDINGS: Spontaneous retrograde movement of 1 or more ureteroliths was detected by radiography, ultrasonography, fluoroscopy, and a combination of fluoroscopy and ultrasonography. The ureteroliths moved retrograde up to 4 centimeters. Retrograde movement of ureteroliths into the renal pelvis resulted in improved renal function in some patients but made complete surgical removal of all uroliths more difficult. TREATMENT AND OUTCOME: Medical management was not successful, and ureteroliths were surgically removed. Surgical management of ureteroliths was complicated by retrograde movement of ureteroliths in the perioperative period. CLINICAL RELEVANCE: Ureteroliths can move retrograde within the ureter and even back into the renal pelvis. Retrograde movement of ureteroliths may make surgical planning more difficult.  相似文献