Composition and antimicrobial activity of <Emphasis Type="Italic">Cistus munbyi</Emphasis> essential oil: an endemic plant from Algeria     

Fethi Benbelaïd  Abdelmounaïm Khadir  Mourad Bendahou  Mohamed Amine Abdoune  Alain Muselli  Jean Costa 《林业研究》2017,28(6):1129-1134

The chemical composition and antimicrobial potential of Cistus munbyi essential oil were studied for the first time. GC and GC–MS analysis revealed 48 compounds representing 96.98% of the oil. Terpinen-4-ol (23.75%), meta-Cymene (17.30%), and Sabinene (12.38%) were the major constituents. Antimicrobial activity was evaluated against nine pathogens using the disc diffusion and broth micro-dilution methods. Results show that C. munbyi essential oil possesses strong antimicrobial activity against all strains, regardless if Gram-positive or Gram-negative bacteria, or yeast, with MICs values not exceeding 10 (mg/ml). In addition to its efficacy, C. munbyi essential oil has an unusual antimicrobial potency which is attributed to its specific chemical composition. Thus, findings presented here suggest that endemic C. munbyi contains a very interesting essential oil that may be valuable in several areas.  相似文献   

A first insight into genotype × diet interactions in European sea bass (Dicentrarchus labrax L. 1756) in the context of plant‐based diet use     

Richard Le Boucher  Marc Vandeputte  Mathilde Dupont‐Nivet  Edwige Quillet  David Mazurais  Jean Robin  Alain Vergnet  Françoise Médale  Sadasivam Kaushik  Béatrice Chatain 《Aquaculture Research》2011,42(4):583-592

This preliminary study assessed genotype × diet interaction in late growth of European sea bass (Dicentrarchus labrax) fed with either a fish meal (FM)‐ or a fish oil (FO)‐based diet (M) or an all‐plant‐based (PB) diet. A total of 550 fish from 224 families were reared together and tagged. DNA was sampled and microsatellites were used to assign parentage. When fish weight was 192 ± 54 g, two tanks were fed with M (FM: 100%; FO: 100%) and two others with PB (FM: 0% and FO: 0%). Body weight (BW), fork length (FL) and fillet lipid content (CorrFat) were analysed with a linear model and with REML methodology. We observed no significant differences between groups, but a slightly lower (P=0.03) daily growth coefficient in sea bass fed PB than in those fed M. Heritability estimates of BW differed significantly from zero (PB: 0.37 ± 0.18; M: 0.47 ± 0.24). Sire × diet interactions were significant and genetic correlations ranged between 0.51 and 0.87, showing genotype × diet interaction for BW and CorrFat. For the first time, genetic parameters in the context of total replacement of marine fishery by‐products were estimated in European sea bass, showing re‐ranking of family performances with extremely contrasted diets.  相似文献   

Natural cyclopeptides as leads for novel pesticides: tentoxin and destruxin     

Florine Cavelier  Jean Verducci  Franois Andr  Francis Haraux  Claude Sigalat  Michel Traris  Alain Vey 《Pest management science》1998,52(1):81-89

Difficulties in synthesis make natural cyclopeptides challenging targets for chemists. Our interest focused on two natural toxic cyclopeptide series produced by pathogenic fungi: tentoxin, [cyclo-(N-MeAla¹-Leu²-N-Meδ^zPhe³-Gly⁴)] and the destruxins [cyclo-(Pro¹-Ile²-N-MeVal³-N-MeAla⁴-β-Ala⁵-HA⁶)]. The total syntheses of these two bioactive series were optimised, and several analogues were designed and synthesised to establish structure–activity relationships. The importance of synthetic analogues in the identification of molecular targets and the explanation of mechanisms of action was demonstrated. Such systematic investigations can determine the crucial features responsible for the activity of the natural compound and help the design of more powerful or more selective products. © 1998 SCI.  相似文献   

Conventional fractionated radiotherapy outcomes for young dogs with nephroblastoma of the spinal cord: 5 cases     

Jaeyoung Kim  Michael Sean Kent  Alain Pierre Théon  Amandine Tamara Lejeune  Katherine Sarah Hansen 《Veterinary and comparative oncology》2023,21(3):419-426

Published radiotherapy results for spinal nephroblastomas in dogs are limited. In this retrospective longitudinal study (1/2007–1/2022), five dogs with a median age of 2.8 years received post-operative 3D conformal, conventional fractionated radiotherapy (CFRT) with 2–4 fields (parallel-opposed with or without two hinge-angle fields), for an incompletely resected nephroblastoma. Clinical findings prior to surgery included one or more of the following: pelvic limb paresis (5), faecal incontinence (2), flaccid tail (1), non-ambulatory (2) and deep pain loss (1). All masses were located between T11 and L3 and surgically removed via hemilaminectomy. Dogs received 45–50 Gray (Gy) in 18–20 fractions, and no dogs received chemotherapy post-radiation. At analysis, all dogs were deceased, with none lost to follow-up. The median overall survival (OS) from first treatment to death of any cause was 3.4 years (1234 days; 95% CI 68 days-upper limit not reached; range: 68–3607 days). The median planning target volume was 51.3 cc, with a median PTV dose of 51.4 Gy and median D98 = 48.3 Gy. Late complications or recurrence was difficult to fully determine in this small dataset; however, some degree of ataxia persisted throughout life in all dogs. This study provides preliminary evidence that post-operative radiotherapy may result in prolonged survival times dogs with spinal nephroblastomas.  相似文献