Two-dimensional nuclear magnetic resonance spectroscopy   总被引：3，自引：0，他引：3  

A Bax  L Lerner 《Science (New York, N.Y.)》1986,232(4753):960-967

Great spectral simplification can be obtained by spreading the conventional one-dimensional nuclear magnetic resonance (NMR) spectrum in two independent frequency dimensions. This so-called two-dimensional NMR spectroscopy removes spectral overlap, facilitates spectral assignment, and provides a wealth of additional information. For example, conformational information related to interproton distances is available from resonance intensities in certain types of two-dimensional experiments. Another method generates 1H NMR spectra of a preselected fragment of the molecule, suppressing resonances from other regions and greatly simplifying spectral appearance. Two-dimensional NMR spectroscopy can also be applied to the study of 13C and 15N, not only providing valuable connectivity information but also improving sensitivity of 13C and 15N detection by up to two orders of magnitude.  相似文献   

Bilateral congenital lateral patellar luxation in a foal.          下载免费PDF全文

N A La Faunce  D J Lerner    T R O''''Brien 《The Canadian veterinary journal. La revue veterinaire canadienne》1971,12(5):119-120

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Dimethyl sulfoxide conference     

Sulzberger MB  Kutscher AH  Lerner HJ 《Science (New York, N.Y.)》1966,153(3736):576

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Anthropology. Autonomous cultivation before domestication     

Weiss E  Kislev ME  Hartmann A 《Science (New York, N.Y.)》2006,312(5780):1608-1610

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Radiative absorption enhancements due to the mixing state of atmospheric black carbon   总被引：3，自引：0，他引：3  

CD Cappa  TB Onasch  P Massoli  DR Worsnop  TS Bates  ES Cross  P Davidovits  J Hakala  KL Hayden  BT Jobson  KR Kolesar  DA Lack  BM Lerner  SM Li  D Mellon  I Nuaaman  JS Olfert  T Petäjä  PK Quinn  C Song  R Subramanian  EJ Williams  RA Zaveri 《Science (New York, N.Y.)》2012,337(6098):1078-1081

Atmospheric black carbon (BC) warms Earth's climate, and its reduction has been targeted for near-term climate change mitigation. Models that include forcing by BC assume internal mixing with non-BC aerosol components that enhance BC absorption, often by a factor of ~2; such model estimates have yet to be clearly validated through atmospheric observations. Here, direct in situ measurements of BC absorption enhancements (E(abs)) and mixing state are reported for two California regions. The observed E(abs) is small-6% on average at 532 nm-and increases weakly with photochemical aging. The E(abs) is less than predicted from observationally constrained theoretical calculations, suggesting that many climate models may overestimate warming by BC. These ambient observations stand in contrast to laboratory measurements that show substantial E(abs) for BC are possible.  相似文献   

Pheromone Research and Development in Israel 1975–2015     

Ezra Dunkelblum  Anat Levi-Zada 《Phytoparasitica》2017,45(5):619-637

The review describes the history of pheromone research in Israel in 1975–2015. The research focused on sex pheromones of moths that were important agricultural pests. Identification, synthesis and field application of sex pheromones was performed. Synthetic procedures of several known sex pheromones were developed. Monitoring and control of key pest moths was evaluated. The interactions of pheromone components of closely related species were studied in field and laboratory experiments. The sex pheromones of three scale insects, two mealybug species and Matsucoccus josephi were studied. New syntheses were developed and the pheromones were implemented in pest management. Structure activity relationship of the pheromonal and kairomonal of the M. josephi pheromone was investigated. Different pherotypes of P. ficus were identified and evaluated. The aggregation pheromone of sap beetles in combination with food baits was evaluated. The aggregation pheromone of the almond bark beetle was identified and a stereospecific synthesis of its enantiomers was developed. Monitoring the pest in stone fruit orchards was implemented. The activity of the pheromone biosynthesis activating neuropeptide (PBAN) was studied in Helicoverpa armigera and Heliothis peltigera. The ligation technique was used to assess the effect of PBAN on the production of female and male pheromones. A structure-activity relationship study of PBAN indicated that shorter peptides display activity as the full length PBAN. A series of linear and cyclic peptide analogs was prepared, resulting in the discovery of a lead antagonist. The research and development activity facilitated the intensive integration of pheromones in the pest management regimes in Israeli agriculture.  相似文献   

Quality and endosperm storage protein variation in Argentinean grown bread wheat. I. Allelic diversity and discrimination between cultivars   总被引：1，自引：1，他引：0  

S.E. Lerner  M.A. Kolman  W.J. Rogers   《Journal of Cereal Science》2009,49(3):337-345

Genetic variability for endosperm storage proteins was analysed in 119 Argentinean grown bread wheat cultivars. For the HMW-GS, three, six and two alleles were observed at the Glu-A1, Glu-B1 and Glu-D1 loci, respectively, in 17 allelic combinations. The majority of these combinations were considered to be associated with good quality. For the LMW-GS, eight, seven and four alleles were provisionally observed at the Glu-A3, Glu-B3 and Glu-D3 loci, respectively, in 51 allelic combinations. Regarding quality, the alleles present at Glu-D3 were mainly those previously shown to be associated with good quality, whereas at Glu-A3 and Glu-B3, some alleles previously associated with poor quality were present at high frequency. Relatively few cultivars carried combinations for all the loci studied that would be expected to be associated with high quality. The mean genetic variation index (H) observed for the glutenin loci (0.589) was similar to values observed in other collections. Unweighted pair-group method using arithmetic averages (UPGMA) of the six loci plus the Chinese Spring-Cheyenne CSS–CNN difference showed that the 119 cultivars fell into 93 distinct combinations. For complete discrimination between all cultivars they would have to be analysed for additional loci. There remains scope for varietal quality improvement within this germplasm pool.  相似文献   

Catalytic antibodies with lipase activity and R or S substrate selectivity   总被引：3，自引：0，他引：3  

K D Janda  S J Benkovic  R A Lerner 《Science (New York, N.Y.)》1989,244(4903):437-440

The specific hydrolysis of unactivated esters bearing an R or S enantiomeric alcohol has been achieved by two separate classes of catalytic antibodies induced to bind either the R or S substrates. The antibodies exhibit rate accelerations (10(3) to 10(5] above background hydrolysis that, coupled with their antipodal specificity, provide a novel set of reagents for use in synthesis.  相似文献   

Small-colon rupture attributable to granulosa cell tumor in a mare   总被引：1，自引：0，他引：1  

D A Wilson  J H Foreman  M J Boero  P J Didier  D J Lerner 《Journal of the American Veterinary Medical Association》1989,194(5):681-682

A large granulosa cell tumor was believed to be responsible for causing obstruction and subsequent rupture of the small colon in a 10-year-old Quarter Horse mare. Two months earlier, a mass, tentatively diagnosed as granulosa cell tumor of the left ovary, had been identified by means of rectal palpation and ultrasonography. The mare was evaluated for clinical signs of acute, severe, abdominal pain, increased heart rate, cyanotic mucous membranes, clinical dehydration, with high PCV, leukopenia, and extreme abdominal distension. A large soft tissue mass and taut band that constricted the lumen of the small colon were palpable per rectum. Septic peritonitis was diagnosed on the basis of results of abdominocentesis. Exploratory surgery revealed extensive fecal contamination of the abdominal viscera, and the mare was euthanatized because of the resultant poor prognosis. At necropsy, the small colon was occluded by a taut, left broad ligament and the ovarian mass that was proved to be a granulosa cell tumor. The occlusion had caused impaction of the small colon, with subsequent perforation at the level of the broad ligament.  相似文献   

THE SHAPE OF THE CHICK EMBRYO GROWTH CURVE     

Lerner IM 《Science (New York, N.Y.)》1939,89(2297):16-17

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