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11.
Elimination of cetirizine following administration of multiple doses to exercised thoroughbred horses 下载免费PDF全文
H. K. Knych S. D. Stanley R. M. Arthur D. S. McKemie 《Journal of veterinary pharmacology and therapeutics》2016,39(5):522-524
Cetirizine is an antihistamine used in performance horses for the treatment of hypersensitivity reactions and as such a withdrawal time is necessary prior to competition. The objective of the current study was to describe the disposition and elimination of cetirizine following oral administration in order to provide additional serum concentration data upon which appropriate regulatory recommendations can be established. Nine exercised thoroughbred horses were administered 0.4 mg/kg of cetirizine orally BID for a total of five doses. Blood samples were collected immediately prior to drug administration and at various times postadministration. Serum cetirizine concentrations were determined and selected pharmacokinetic parameters determined. The serum elimination half‐life was 5.83 ± 0.841 h. Average serum cetirizine concentrations were still above the LOQ of the assay (0.05 ng/mL) at 48 h (final sample collected) postadministration of the final dose. 相似文献
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In previous work, a mouse line selected for resistance (R) to fescue toxicosis had higher activities of two hepatic Phase II detoxification enzymes than a mouse line selected for fescue toxicosis susceptibility (S). The primary objective of the present study was to determine whether those same lines also differed in hepatic Phase I enzyme activity, estimated from sleep time (ST) following sodium pentobarbital anesthesia. Additional objectives were to determine whether ST differences between lines were modulated by endophyte-infected fescue in the diet (with or without an enzyme inducer) and whether ST of individual mice was correlated with the effect of a toxin-containing diet on the postweaning growth of those mice. In Exp. I, 24 males from each line were randomly assigned to each of five diets: control (commercial rodent food meal); E+ (50% endophyte-infected fescue seed, 50% control); E+P (the E+ diet supplemented with 1,000 ppm phenobarbital); E- (50% endophyte-free fescue seed, 50% control); and E-P (the E- diet supplemented with 1,000 ppm phenobarbital). After 4 wk on these diets, ST was measured on all the mice. A second ST was recorded on each mouse by randomly sampling one-fourth of the population after 1, 2, 3, or 4 wk on a pelleted rodent food diet. Regardless of diet, R mice had shorter first and second ST than S mice (P < 0.01), suggesting higher hepatic Phase I microsomal enzyme activity. Mice on both phenobarbital-supplemented diets had shorter first ST than mice whose diets did not include that microsomal enzyme inducer (P < 0.01). In Exp. II, ST was measured on male and female R and S mice (n = 280) after they had been fed the E- diet for 2 wk, then the E+ diet for 2 wk, and then a pelleted rodent food diet for 2 wk. Growth response to the E+ diet was the percentage of reduction in gain on the E+ diet compared to gain on the E- diet the previous 2 wk. As in Exp. I, S mice slept longer than R mice (P < 0.01). The residual correlation between ST and gain reduction associated with the E+ diet equaled 0.04. Thus, an animal's apparent Phase I enzyme activity did not predict its growth rate depression on the toxin-containing diet. Based on these and previous studies, divergent selection for toxicosis response in mice was successful partially by causing divergence in activities of hepatic Phase I and II detoxification enzymes. 相似文献
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AIM: To describe the gross and histological lesions of a neurological disease in Borderdale sheep characterised clinically by blindness and circling, as a basis to its classification. METHODS: Formalin-fixed tissues were processed into paraffin wax and epoxy resin for light and electron microscopy of variously stained sections. RESULTS: Lesions were those of a lysosomal storage disease with severe neurodegeneration of the cerebral cortex. The staining reactions, autofluorescence and ultrastructure of storage material allowed the diagnosis of neuronal ceroid-lipofuscinosis associated with the accumulation of subunit-c of mitochondrial ATP synthase. CONCLUSIONS: The severity of neurodegeneration and minor differences in the ultrastructure of storage material implied that this was a different disease from other forms of ovine ceroid-lipofuscinosis that accumulate subunit-c of mitochondrial ATP synthase. An autosomal recessive mode of inheritance is considered probable. Although of only minor economic importance, this disease may be important to research into the group of ceroid-lipofuscinoses as a whole. 相似文献
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Empirical relationships between land use/cover and estuarine condition in the Northeastern United States 总被引:1,自引:0,他引:1
Wilfrid Rodriguez Peter V. August Yeqiao Wang John F. Paul Arthur Gold Norman Rubinstein 《Landscape Ecology》2007,22(3):403-417
Land–water interactions were examined in three regions in the Virginian Biogeographic Province; the southern shore of Cape
Cod, Massachusetts; the Hudson/Raritan region of New York; and the eastern shore of the Delmarva (Delaware/Maryland/Virginia)
Peninsula. Cumulative distribution functions were used to evaluate similarity in environmental condition among estuaries.
Spatial-setting variables (location in a river, coastal lagoon, or in open waters) were associated with variation for some
measures of estuarine condition. Patterns of coastal urban and agriculture gradients were measured and their relationship
with indicators of estuarine condition was modeled statistically. When estuaries were pooled, the highest variation explained
by spatial-setting variables was found for dissolved oxygen (DO, R
2 = 0.44) and salinity (R
2 = 0.58), with DO decreasing in river locations and salinity decreasing with rainfall and sampling locations near rivers.
The explanatory power for the other indicator variables was low and varied from 6% to 27%. Rainfall explained some of the
variation (R
2 = 0.23) in total suspended solids. Moderate (0.4 < | r | < 0.7) to strong (| r | ≥ 0.7) linear associations were found between total urban area and measures of estuarine condition. Within regions, total
urban area was positively associated with Silver (r = 0.59), Cadmium (r = 0.65), and Mercury (r = 0.47) in Cape Cod, and inversely related to DO (r = −0.65) in the Hudson/Raritan region. No associations were found in the Delmarva Peninsula study area. Total area of agriculture
showed a moderate association with Arsenic in Cape Cod, but no other associations were found in the other two regions. Our
analyses show a measurable impact of urban land use on coastal ecosystem condition over large areas of the northeastern United
States. This pattern was most evident when many different landscapes were considered simultaneously. The relationship between
urban development and estuarine condition were weaker within the individual regions studied. The use of land use/cover models
for predicting estuarine condition is a challenging task that warrants enhancements in the type, quantity, and quality of
data to improve our ability to discern relationships between anthropogenic activities on land and the condition of coastal
environments. 相似文献
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Arthur E. L. Morris Lance R. Williams P. Charles Goebel Eugene C. Braig IV 《Ecology of Freshwater Fish》2012,21(4):597-608
Wood in streams functions as fish habitat, but relationships between fish abundance (or size) and large wood in streams are not consistent. One possible reason for variable relationships between fish and wood in streams is that the association of fish with wood habitat may depend on ecological context such as large‐scale geomorphology. We studied the relationship between salmonid assemblages and large wood jams (LWJ) in four settings that differed geomorphically at the scale of the stream corridor along a tributary to Lake Superior in old‐growth conifer–hardwood forest in northern Michigan. The focal fish species of this study were brook trout (Salvelinus fontinalis), which were wild in the stream. Relocation efforts for coaster brook trout (an adfluvial life history variant of brook trout) were ongoing in the study stream. We measured fish abundance and length in pairs of pools of similar size and substrate, but varying in the presence of LWJ; this allowed us to evaluate associations of fish simply with the presence of LWJ rather than with other channel or flow‐shaping functions of LWJ. The length of Oncorhynchus spp. and young introduced brook trout was not strongly correlated with LWJ presence; however, the presence of LWJ in pools was positively correlated with larger wild brook trout. We also found that the correspondence of LWJ with the abundance of salmonids appears to be moderated by the presence of alternative habitat in this relatively natural, old‐growth forest stream. 相似文献
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Arthur Troughton 《Euphytica》1965,14(1):59-66
The intra-varietal variation of plants of Irish and S. 23 perennial ryegrass (Lolium perenne) growing in nutrient solution was studied in separate experiments.The variation in shoot growth was due to differences in both the rate of production and size of the tillers, while in root growth it was related to the size of individual roots. Root relative to shoot growth was also related to the size of the individual roots.In both varieties the frequency-distribution of size of individual roots and rate of root growth compared with shoot growth was positively skew. Root characters were more variable than shoot characters. The results are discussed in relation to possible selection pressures and morphology. 相似文献
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Sousa Larissa Nascimento Batista Samira Pereira Silva Samara Santos da Silva Rômulo Fylipe Sarmento Wlysse Ferreira Mota Rinaldo Aparecido Brasil Arthur Willian Lima Amaku Marcos Feitosa Thais Ferreira Vilela Vinícius Longo Ribeiro 《Veterinary research communications》2022,46(2):507-515
Veterinary Research Communications - This study aimed to describe the transmission of T. gondii in naturally infected goats in the semiarid region of northeastern Brazil, through evaluating the... 相似文献
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