Pharmacokinetics of firocoxib in preweaned calves after oral and intravenous administration     

M. L. Stock  R. Gehring  L. A. Barth  L. W. Wulf  J. F. Coetzee 《Journal of veterinary pharmacology and therapeutics》2014,37(5):457-463

The objective of this study was to determine the pharmacokinetics of intravenous and oral firocoxib in 10 healthy preweaned calves. Firocoxib (0.5 mg/kg) was initially administered i.v. to calves, and following a 14‐day washout period, animals received firocoxib orally prior to cautery dehorning. Firocoxib concentrations were determined by liquid chromatography–tandem mass spectrometry. Changes in hematology and plasma chemistry were determined using automated methods. Computer software was used to estimate pharmacokinetic parameters best described with a two‐compartment model for i.v. administration and a one‐compartment model for p.o. administration. Following i.v. dosing, the geometric mean (range) T_1/2K10 and T_1/2β were 6.7 (4.6–9.7) and 37.2 (23.5–160.4) h, respectively, V_ss was 3.10 (2.10–7.22) L/kg, and CL was 121.7 (100.1–156.7) mL/h/kg. Following oral administration, geometric mean (range) C_max was 127.9 (102.5–151.3) ng/mL, T_max was 4.0 (2.6–5.6) h, and T_1/2K10 was 18.8 (14.2–25.5) h. Bioavailability of oral firocoxib was calculated using the AUC derived from both study populations to be 98.4% (83.1–117.6%). No adverse clinical effects were evident following firocoxib administration. Pharmacokinetic analysis of i.v. and p.o. firocoxib indicates high bioavailability and a prolonged terminal half‐life in preweaned calves.  相似文献   

Comparison of different diagnostic tools for the detection of Anaplasma phagocytophilum in dogs     

Charlotte Barth  Reinhard K. Straubinger  Elisabeth Müller  Carola Sauter‐Louis  Katrin Hartmann 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2014,43(2):180-184

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In vivo activity of native GnRHs and their analogues on ovulation in the African catfish, Clarias gariepinus (Burchell)     

Tamás Szabó  Ferenc Radics  Tomislav Barth  & László Horváth 《Aquaculture Research》2007,38(2):140-146

Four distinct forms of native gonadotropin‐releasing hormone (GnRH) and two newly designed analogues were tested for their in vivo activity to induce ovulation in African catfish. The effects of these peptides on ovulatory parameters were compared with those of carp pituitary and [d ‐Ala⁶, Pro⁹‐NEt]‐mammalian GnRH analogue (mGnRHa), two tested ovulation‐inducing agents in African catfish. Assessment of ovulation was carried out by determining the ovulation ratio and the relative quantity of egg produced. From the results of the experiments, the order of potency of the native GnRH peptides is summarized as chicken GnRH‐II (cGnRH‐II) >salmon GnRH (sGnRH) >mammalian GnRH >chicken GnRH‐I (cGnRH‐I). Chicken GnRH‐II was as potent as mGnRHa while cGnRH‐I was totally ineffective. The new d ‐Orn⁶‐cGnRH‐II and d ‐Orn⁶‐sGnRH with a substitution at position 6 with d ‐isomer residue were as potent as the most extensively used mGnRHa, indicating that the position 6 modification might be more crucial than the substitution at the C‐terminal. On the basis of our results, the potential use and incorporation of cGnRH‐II and sGnRH for the development of more generic spawning induction therapies are suggested.  相似文献   

Chloramphenicol 3. Clinical pharmacology of systemic use in the horse     

SW PAGE 《Australian veterinary journal》1991,68(1):5-8

The use of chloramphenicol in the horse is now prohibited as horses are classified as food-producing animals. However, chloramphenicol has until recently been widely available for oral, intramuscular or intravenous administration. A critical appraisal of the published literature on the use of chloramphenicol in the horse clearly demonstrates that there are sound pharmacokinetic and microbiological reasons for concluding that chloramphenicol is not an appropriate antibiotic for systemic use. The short half-life of chloramphenicol in the horse, together with the broad range of minimum inhibitory concentrations of target pathogens, preclude the use of practical dosage regimens. It can be concluded that the withdrawal of chloramphenicol will have no adverse effects on chemotherapy in the horse.  相似文献   

Serum proteins of worm-infested deer (Capreolus capreolus L. 1758). Comparison between ordinary and immunoelectrophoresis     

L Róka  H Hartwig  D Barth 《Zentralblatt für Veterin?rmedizin. Reihe B. Journal of veterinary medicine. Series B》1985,32(2):128-136

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Amyloidosis induced in mice by Escherichia coli endotoxin   总被引：7，自引：0，他引：7  

W F Barth  J K Gordon  J T Willerson 《Science (New York, N.Y.)》1968,162(854):694-695

Amyloidosis was produced in mice by repeated subcutaneous injections of 0.5-or 0.005-milligram amounts of Escherichia coli endotoxin. Of the two strains of mice examined, amyloidosis was induced more readily in one than in the other. The ability of endotoxin to induce amyloidosis lends support to the view that stimulation of reticuloendothelial cells leads to amyloid formation.  相似文献   

Rutile-bearing refractory eclogites: missing link between continents and depleted mantle   总被引：9，自引：0，他引：9  

Rudnick RL  Barth M  Horn I  McDonough WF 《Science (New York, N.Y.)》2000,287(5451):278-281

A mass imbalance exists in Earth for Nb, Ta, and possibly Ti: continental crust and depleted mantle both have subchondritic Nb/Ta, Nb/La, and Ti/Zr, which requires the existence of an additional reservoir with superchondritic ratios, such as refractory eclogite produced by slab melting. Trace element compositions of minerals in xenolithic eclogites derived from cratonic lithospheric mantle show that rutile dominates the budget of Nb and Ta in the eclogites and imparts a superchondritic Nb/Ta, Nb/La, and Ti/Zr to the whole rocks. About 1 to 6 percent by weight of eclogite is required to solve the mass imbalance in the silicate Earth, and this reservoir must have an Nb concentration >/= 2 parts per million, Nb/La >/= 1.2, and Nb/Ta between 19 and 37-values that overlap those of the xenolithic eclogites. As the mass of eclogite in the continental lithosphere is significantly lower than this, much of this material may reside in the lower mantle, perhaps as deep as the core-mantle boundary.  相似文献   

Emergence of anoxia in the California current large marine ecosystem     

Chan F  Barth JA  Lubchenco J  Kirincich A  Weeks H  Peterson WT  Menge BA 《Science (New York, N.Y.)》2008,319(5865):920

Eastern boundary current systems are among the world's most productive large marine ecosystems. Because upwelling currents transport nutrient-rich but oxygen-depleted water onto shallow seas, large expanses of productive continental shelves can be vulnerable to the risk of extreme low-oxygen events. Here, we report the novel rise of water-column shelf anoxia in the northern California Current system, a large marine ecosystem with no previous record of such extreme oxygen deficits. The expansion of anoxia highlights the potential for rapid and discontinuous ecosystem change in productive coastal systems that sustain a major portion of the world's fisheries.  相似文献   

Species Abundance: Natural Regulation of Insular Variation     

Hamilton TH  Rubinoff I  Barth RH  Bush GL 《Science (New York, N.Y.)》1963,142(3599):1575-1577

Variation in numbers of land plant species on islands in the Galapagos Archipelago can be predicted on the basis of elevation, area of the adjacent island, distance from the nearest island, and distance from the center of the archipelago, but not on the basis of the area of the host island. Multiple linear regression (y = bx(1) + bx(2) . . .) gives better "goodness of fit" than curvilinear analysis (y = bx(z)). The variation in number of species on large islands can be predicted more accurately than the variation on small ones. Ecologic diversity and isolation are the natural regulators of species abundance.  相似文献   

Detection of c-sis transcripts and synthesis of PDGF-like proteins by human osteosarcoma cells   总被引：17，自引：0，他引：17  

D T Graves  A J Owen  R K Barth  P Tempst  A Winoto  L Fors  L E Hood  H N Antoniades 《Science (New York, N.Y.)》1984,226(4677):972-974

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