Ethical question on food animal practitioner treating mange — A comment     

Florence Barton 《The Canadian veterinary journal. La revue veterinaire canadienne》2014,55(6):513

  相似文献   

Transendoscopic Laser Surgery to Correct Nasopharyngeal Obstruction Caused by Head Flexion in Horses     

Ann Kristin Barton DVM  Diplomate ECEIM  Anja Cehak DVM  Diplomate ECEIM  Karl Rohn DVM  Bernhard Ohnesorge Prof.  DVM  Diplomate ECEIM 《Veterinary surgery : VS》2014,43(4):418-424

  相似文献   

Efficacy of cyclo‐oxygenase inhibition by two commercially available firocoxib products in horses     

M. H. Barton  E. Paske  N. Norton  D. King  S. Giguère  S. Budsberg 《Equine veterinary journal》2014,46(1):72-75

  相似文献   

Characteristics of residency training associated with first‐time pass rate on the American College of Veterinary Ophthalmologists certifying examination     

Diane V. H. Hendrix  Ellison Bentley  Barton W. Rohrbach 《Veterinary ophthalmology》2014,17(4):233-240

  相似文献   

The International Breeder's Rights System and Crop Plant Innovation     

Barton JH 《Science (New York, N.Y.)》1982,216(4550):1071-1075

Legal arrangements governing a plant breeder's intellectual property rights to his inventions are likely to affect the future of crop research. Such systems, although controversial, are probably currently desirable for the developed world. The new genetic technologies may change this judgment, and certainly require redefinition of the lines between plant patents and regular patents. Several safeguards, present in the United States breeder's rights law, should be applied more broadly. A new safeguard-of ensuring that material be entered into germplasm banks-should be applied everywhere. For the developing world, the desirability of a plant patent system is much less clear; new agreements may be desirable to ensure the free flow and collection of germplasm.  相似文献   

Plant biology. Plant acupuncture: sticking PINs in the right places     

Kaplinsky NJ  Barton MK 《Science (New York, N.Y.)》2004,306(5697):822-823

  相似文献   

Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing     

Wu X  Zhou T  Zhu J  Zhang B  Georgiev I  Wang C  Chen X  Longo NS  Louder M  McKee K  O'Dell S  Perfetto S  Schmidt SD  Shi W  Wu L  Yang Y  Yang ZY  Yang Z  Zhang Z  Bonsignori M  Crump JA  Kapiga SH  Sam NE  Haynes BF  Simek M  Burton DR  Koff WC  Doria-Rose NA  Connors M;NISC Comparative Sequencing Program  Mullikin JC  Nabel GJ  Roederer M  Shapiro L  Kwong PD  Mascola JR 《Science (New York, N.Y.)》2011,333(6049):1593-1602

Antibody VRC01 is a human immunoglobulin that neutralizes about 90% of HIV-1 isolates. To understand how such broadly neutralizing antibodies develop, we used x-ray crystallography and 454 pyrosequencing to characterize additional VRC01-like antibodies from HIV-1-infected individuals. Crystal structures revealed a convergent mode of binding for diverse antibodies to the same CD4-binding-site epitope. A functional genomics analysis of expressed heavy and light chains revealed common pathways of antibody-heavy chain maturation, confined to the IGHV1-2*02 lineage, involving dozens of somatic changes, and capable of pairing with different light chains. Broadly neutralizing HIV-1 immunity associated with VRC01-like antibodies thus involves the evolution of antibodies to a highly affinity-matured state required to recognize an invariant viral structure, with lineages defined from thousands of sequences providing a genetic roadmap of their development.  相似文献   

Development of gynogenetic eggs in the mouse: implications for parthenogenetic embryos   总被引：8，自引：0，他引：8  

M A Surani  S C Barton 《Science (New York, N.Y.)》1983,222(4627):1034-1036

Mouse eggs with different genetic constitutions were prepared by micromanipulation of fertilized diploids and triploids. The diploid gynogenones, activated by the male gamete which was then removed, developed at best to about the 25-somite stage as did the genetically similar diploid parthenogenones stimulated to develop in the complete absence of the male gamete. The failure of development to term in both cases may be due to homozygosity and does not appear to be due to a lack of extragenetic contribution from spermatozoa.  相似文献   

Chromosomal speciation and molecular divergence--accelerated evolution in rearranged chromosomes     

Navarro A  Barton NH 《Science (New York, N.Y.)》2003,300(5617):321-324

Humans and their closest evolutionary relatives, the chimpanzees, differ in approximately 1.24% of their genomic DNA sequences. The fraction of these changes accumulated during the speciation processes that have separated the two lineages may be of special relevance in understanding the basis of their differences. We analyzed human and chimpanzee sequence data to search for the patterns of divergence and polymorphism predicted by a theoretical model of speciation. According to the model, positively selected changes should accumulate in chromosomes that present fixed structural differences, such as inversions, between the two species. Protein evolution was more than 2.2 times faster in chromosomes that had undergone structural rearrangements compared with colinear chromosomes. Also, nucleotide variability is slightly lower in rearranged chromosomes. These patterns of divergence and polymorphism may be, at least in part, the molecular footprint of speciation events in the human and chimpanzee lineages.  相似文献   

The principles of conformational analysis     

Barton DH 《Science (New York, N.Y.)》1970,169(3945):539-544

  相似文献