Hematologic changes associated with weekly low-dose cisplatin administration in dogs     

Hahn KA  Rohrbach BW  Legendre AM  Frazier DL  Nolan ML 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》1997,26(1):29-31

This study prospectively describes the systemic toxicity of cisplatin (20 mg/m(2),IV) when given in weekly doses prior to localized irradiation in dogs with solid malignancies. Eleven dogs received a total of 54 weekly doses of cisplatin. Two dogs did not complete the 5-week protocol due to progressive disease and two dogs received 6 weekly doses of cisplatin. Repeated administration of cisplatin caused a significant decline in the leukocyte count, segmented neutrophil count, and platelet count. These changes were related to the number of cisplatin doses. The dogs did not have any significant alteration of blood urea nitrogen, serum creatinine, or urine specific gravity during the treatment period. Weekly low-dose cisplatin, as used in this study, is safe for use in tumor-bearing dogs. However, the significant decline in the leukocyte, segmented neutrophil, and platelet counts in these 11 dogs suggest that cisplatin prescribed at 20 mg/m(2) IV once per week should not exceed five consecutive treatments.  相似文献   

Effects of acepromazine and butorphanol on tiletamine-zolazepam anesthesia in llamas     

Prado TM  Doherty TJ  Boggan EB  Airasmaa HM  Martin-Jimenez T  Rohrbach BW 《American journal of veterinary research》2008,69(2):182-188

OBJECTIVE: To evaluate sedative, antinociceptive, and physiologic effects of acepromazine and butorphanol during tiletamine-zolazepam (TZ) anesthesia in llamas. ANIMALS: 5 young adult llamas. PROCEDURES: Llamas received each of 5 treatments IM (1-week intervals): A (acepromazine, 0.05 mg/kg), B1 (butorphanol, 0.1 mg/kg), AB (acepromazine, 0.05 mg/kg, and butorphanol, 0.1 mg/kg), B2 (butorphanol, 0.2 mg/kg), or C (saline [0.9% NaCl] solution). Sedation was evaluated during a 30-minute period prior to anesthesia with TZ (2 mg/kg, IM). Anesthesia and recovery characteristics and selected cardiorespiratory variables were recorded at intervals. Antinociception was assessed via a toe-clamp technique. RESULTS: Sedation was not evident following any treatment. Times to sternal and lateral recumbency did not differ among treatments. Duration of lateral recumbency was significantly longer for treatment AB than for treatment C. Duration of antinociception was significantly longer for treatments A and AB, compared with treatment C, and longer for treatment AB, compared with treatment B2. Treatment B1 resulted in a significant decrease in respiratory rate, compared with treatment C. Compared with treatment C, diastolic and mean blood pressures were lower after treatment A. Heart rate was increased with treatment A, compared with treatment B1 or treatment C. Although severe hypoxemia developed in llamas anesthetized with TZ alone and with each treatment-TZ combination, hemoglobin saturation remained high and the hypoxemia was not considered clinically important. CONCLUSIONS AND CLINICAL RELEVANCE: Sedation or changes in heart and respiratory rates were not detected with any treatment before administration of TZ. Acepromazine alone and acepromazine with butorphanol (0.1 mg/kg) prolonged the duration of antinociception in TZ-treated llamas.  相似文献   

Multinodular pulmonary fibrosis,pancytopenia and equine herpesvirus‐5 infection in a Thoroughbred gelding     

K. A. Hart  M. H. Barton  K. J. Williams  M. J. B. F. Flaminio  E. W. Howerth 《Equine Veterinary Education》2008,20(9):470-476

A 21‐year‐old Thoroughbred gelding was examined for intermittent fever, lethargy, inappetance and weight loss. Initial diagnostic evaluation revealed pancytopenia (anaemia, thrombocytopenia and neutropenia), hyperfibrinogenaemia and multifocal pulmonary nodules. Bacterial and fungal culture and viral isolation on transtracheal aspirate samples were negative, consistent with either pulmonary neoplasia, idiopathic granulomatous pneumonia or equine multinodular pulmonary fibrosis (EMPF). Bone marrow evaluation was consistent with pancytopenia due to a combination of peripheral consumption/destruction and suppression/destruction of progenitor cells at the level of the marrow. Pancytopenia resolved and clinical signs improved transiently with immunosuppressive corticosteroid therapy, but the horse deteriorated rapidly one month after presentation and was subjected to euthanasia. Necropsy findings were consistent with EMPF, and equine herpesvirus‐5 (EHV‐5) DNA was found in both the lung and bone marrow. The specific role of EHV‐5 in the development of the pulmonary pathology in EMPF and the pancytopenia in this horse is unclear, but an aberrant host immune/inflammatory response to EHV‐5 infection may be important.  相似文献   

Preliminary investigation of orally administered benazepril in horses with left‐sided valvular regurgitation          下载免费PDF全文

T. Afonso  S. Giguère  S. A. Brown  M. H. Barton  G. Rapoport  M. Barba  K. A. Dembek  R. E. Toribio  A. E. Coleman 《Equine veterinary journal》2018,50(4):446-451

  相似文献   

SECTION ON PHYSICS (B)     

Barton HA 《Science (New York, N.Y.)》1938,88(2274):93-94

  相似文献   

Valuing irrigation water using survey-based methods in the Tungabhadra River Basin, India     

David N. Barton  Avinandan Taron 《Irrigation and Drainage Systems》2010,24(3-4):265-277

The paper discusses the challenges in using survey-based methods of economic valuation of water: choice experiments, residual value of water and water trading prices. The three different approaches to economic valuation of irrigation water are compared, all based on data from a farmer survey conducted in two irrigation command areas in the Tungabhadra sub-basin (Karnataka State, India). Prices reported by farmers for sale and purchase of an additional irrigation are of the same order as willingness to pay estimates derived from a choice experiment. Because of small number of water trades there is large variation in market-price based estimates. Financial returns to a given crop as a function of irrigation frequency show values that are both lower (for rice) and higher (for areca nut) than choice experiment estimates. Low convergent validity of different economic valuation methods of irrigation water, is in part due to the large variation in water availability and farm conditions across the watershed, but also because of methodological weaknesses. While recognizing these weaknesses, the paper shows that representative farm surveys using a combination of valuation methods can identify heterogeneity in farm conditions and preferences that may otherwise be overlooked when carrying out irrigation pricing reform.  相似文献   

The interaction of nitrous oxide and fentanyl on the minimum alveolar concentration of sevoflurane blocking motor movement (MACNM) in dogs     

Reza Seddighi  Thomas J. Doherty  Butch Kukanich  Christine M. Egger  Melissa A. Henn  Whitney M. Long  Barton W. Rohrbach 《Canadian journal of veterinary research》2014,78(3):202-206

The study objective was to determine the effects of 70% nitrous oxide (N₂O) and fentanyl on the end-tidal concentration of sevoflurane necessary to prevent movement (MAC_NM) in response to noxious stimulation in dogs. Six healthy, adult, intact male, mixed-breed dogs were used on 3 occasions in a randomized crossover design. After induction of anesthesia with sevoflurane, each of the following treatments was randomly administered: fentanyl loading dose (Ld) of 15 μg/kg and infusion of 6 μg/kg per hour [treatment 1 (T1)], 70% N₂O (T2), or fentanyl (Ld of 15 μg/kg and infusion of 6 μg/kg per hour) combined with 70% N₂O (T3). Each dog received each of the 3 treatments once during the 3-week period. Determination of MAC_NM was initiated 90 min after the start of each treatment. The values were compared using the baseline MAC_NM, which had been determined in a previous study on the same group of dogs. Data were analyzed using a mixed-model analysis of variance (ANOVA) and Tukey-Kramer tests, and expressed as least squares mean ± SEM. The baseline MAC_NM decreased by 36.6 ± 4.0%, 15.0 ± 4.0%, and 46.0 ± 4.0% for T1, T2, and T3, respectively (P < 0.05), and differed (P < 0.05) among treatments. Mean fentanyl plasma concentrations did not differ (P ≥ 0.05) between T1 (3.70 ± 0.56 ng/mL) and T3 (3.50 ± 0.56 ng/mL). The combination of fentanyl and N₂O resulted in a greater sevoflurane MAC_NM sparing effect than either treatment alone.  相似文献   

Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Hospitalized Neonatal Foals     

K.A. Hart  N.M. Slovis  M.H. Barton 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2009,23(4):901-912

Background: Transient hypothalamic-pituitary-adrenal (HPA) axis dysfunction occurs frequently in critically ill humans and impacts survival. The prevalence and impact of HPA axis dysfunction in critically ill neonatal foals are not well characterized.
Hypotheses: (1) HPA axis dysfunction occurs in hospitalized neonatal foals, and is characterized by inappropriately low basal serum cortisol concentration or inadequate cortisol response to exogenous adrenocorticotropic hormone (ACTH); (2) hospitalized foals with HPA axis dysfunction have more severe disease and are less likely to survive than hospitalized foals with normal HPA axis function.
Animals: Seventy-two hospitalized foals and 23 healthy age-matched foals.
Methods: Basal ACTH and cortisol concentrations were measured and a paired low-dose (10 μg)/high-dose (100 μg) cosyntropin stimulation test was performed at admission in hospitalized foals. HPA axis dysfunction was defined as (1) an inappropriately low basal cortisol concentration or (2) an inadequate increase in cortisol concentration (delta cortisol) after administration of cosyntropin, with cut-off values for appropriate basal and delta cortisol concentrations determined from results obtained in healthy age-matched foals.
Results: Forty-six percent of hospitalized foals had an inappropriately low basal cortisol concentration and 52% had an inadequate delta cortisol concentration after administration of the 100 μg dose of cosyntropin. An inadequate delta cortisol response to the high (100 μg) dose of cosyntropin was significantly correlated with shock and multiple organ dysfunction syndrome in hospitalized foals, and with decreased survival in a subgroup of septic foals.
Conclusions and Clinical Importance: HPA axis dysfunction occurs frequently in hospitalized neonatal foals, and negatively impacts disease severity and survival.  相似文献   

A pilot study evaluating changes in pancreatic lipase immunoreactivity concentrations in canines treated with L-asparaginase (ASNase), vincristine, or both for lymphoma          下载免费PDF全文

Zachary Wright  Joerg Steiner  Jan Suchodolski  Kenita Rogers  Claudia Barton    Marjorie Brown 《Canadian journal of veterinary research》2009,73(2):103-110

L-asparaginase (ASNase) is a common chemotherapy agent for the treatment of lymphoid malignancies. L-asparaginase has been reported to cause clinical pancreatitis in both humans and canines. Canine pancreatic lipase immunoreactivity (cPLI) is now a common diagnostic tool for evaluating pancreatitis in dogs. A total of 52 dogs were enrolled into this study. Canine pancreatic lipase immunoreactivity (cPLI) concentrations were evaluated before and after administration of ASNase, vincristine, or both. All dogs enrolled in the study were evaluated for signs compatible with clinical pancreatitis. No dogs receiving ASNase alone showed evidence of clinical pancreatitis after administration. Also, there was no statistically significant change in cPLI concentrations before or after treatment. Fourteen percent of dogs that received both vincristine and ASNase concurrently had elevated concentrations of cPLI after treatment. Of the 11 dogs with clinical signs compatible with pancreatitis after any chemotherapy treatment, no dog had a cPLI concentration > 400 μg/dL. In conclusion, ASNase did not cause clinical pancreatitis in this cohort of dogs but larger sample sizes are required to further validate this data.  相似文献   

Cervical vertebral anomaly and ventricular septal defect in an Arabian foal     

S. S. Crochik  M. H. Barton  R. B. Eggleston  M. Kent 《Equine Veterinary Education》2009,21(4):207-211

A male Arabian foal born with a cervical mass and no apparent clinical signs presented with a cervical vertebral anomaly and ventricular septal defect. Both congenital anomalies were diagnosed at age 3 weeks and rechecked at age 6 months with radiographs and ultrasonographic studies respectively. At 11 months, in addition to radiographs and Doppler ultrasonographic studies, a contrast ultrasonographic study and post mortem myelographic and computed tomographic studies of the cervical vertebral column revealed the appearance of this rare cervical vertebral anomaly and the severity of the ventricular septal defect. To the authors' knowledge, in the Arabian foal, both conditions have not been reported simultaneously in the same patient.  相似文献