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41.
The majority of pregnancy loss in ruminants occurs during the first three weeks after conception, particularly during the period of conceptus elongation that occurs prior to pregnancy recognition and implantation. This review integrates established and new information on the biological role of ovarian progesterone(P4), prostaglandins(PGs),interferon tau(IFNT) and cortisol in endometrial function and conceptus elongation. Progesterone is secreted by the ovarian corpus luteum(CL) and is the unequivocal hormone of pregnancy. Prostaglandins(PGs) and cortisol are produced by both the epithelial cells of the endometrium and the trophectoderm of the elongating conceptus. In contrast, IFNT is produced solely by the conceptus trophectoderm and is the maternal recognition of pregnancy signal that inhibits production of luteolytic pulses of PGF2αby the endometrium to maintain the CL and thus production of P4. Available results in sheep support the idea that the individual, interactive, and coordinated actions of P4, PGs, IFNT and cortisol regulate conceptus elongation and implantation by controlling expression of genes in the endometrium and/or trophectoderm. An increased knowledge of conceptus-endometrial interactions during early pregnancy in ruminants is necessary to understand and elucidate the causes of infertility and recurrent early pregnancy loss and provide new strategies to improve fertility and thus reproductive efficiency. 相似文献
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Ruth?KingEmail author Stephen?P.?Brooks 《Journal of Agricultural, Biological & Environmental Statistics》2003,8(4):486-513
This article is motivated by a series of data on a population of mouflons (Ovisgmelini) in the Caroux-Espinouse massif and focuses upon discriminating between competing biological hypotheses corresponding to the dependence of any or all of the population parameters upon either sex, location, or age. We show how we can analyze the data using a Bayesian approach, where we are able to take into account prior information obtained via a previous radio-tagging study. We consider the Arnason-Schwarz model together with its submodels to describe the data. Efficiently exploring model space using reversible jump Markov chain Monte Carlo methodology, we are able to calculate model-averaged estimates of parameters of interest, which incorporate both parameter and model uncertainty. In addition, we quantitatively compare different biological hypotheses by calculating their corresponding posterior probabilities. In particular, we show that survival rates tend to remain constant with some evidence to suggest a slight senescent decline. We also provide evidence to suggest that movement around the habitat is largely the same for both sexes up until age 4, when the males appear to extend their migration range, venturing further from the main flock in search of better grazing. 相似文献
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Steven W. Effler Carol M. Brooks Jeffrey M. Addess Susan M. Doerr Michelle L. Storey Bruce A. Wagner 《Water, air, and soil pollution》1991,55(3-4):427-444
Concentrations of Cl, total ammonia (TNH3), NO3 plus NO2, total P (TP), and soluble reactive P (SRP) were measured at two sites, located 5 km apart, on Ninemile Creek, New York, for a period of more than 8 mo. The sites bound the most recently formed Solvay waste beds, associated with the production of soda ash, that adjoin the creek. Concentrations of Cl and T-NH3 increased on average by factors of 16.1 and 7.6, respectively, over the monitored stream reach. The estimated average loadings of these materials to the stream over this reach were 2.3 × 105 and 1.2 × 102 kg d?1, respectively. These inputs are attributable to the Solvay waste beds. The loading of Cl from this source has not changed significantly over a 4 yr period since the closure of the soda ash manufacturing facility. This is the single largest source of Cl, and the second largest source of T-NH3, to polluted Onondaga Lake. Profiles of Cl in the lake indicated that at times the creek inflow plunges to subsurface layers as a result of its elevated density. This is at least in part a result of the creek's ionic enrichment. The concentration of SRP decreased by a factor of 2.0 on average over the study reach, probably due to adsorption to the CaCO3 deposits that cover the stream bed in this area. However, the TP load from the creek to the lake is not significantly affected by this phenomenon. 相似文献
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Brooks FG 《Science (New York, N.Y.)》1928,68(1760):277-278
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