Threshold dose of three photosensitizers in dogs with spontaneous tumors     

Gloi AM  Beck E 《Veterinary therapeutics : research in applied veterinary medicine》2003,4(3):269-278

Photodynamic threshold doses in dogs with spontaneous tumors can be achieved through a mathematical model. For this to be clinically relevant, it is important to know the treatment parameters for tissue necrosis. The threshold dose for three photosensitizers (porfimer sodium, aluminum cholorophthalocyanine [AlClPc], and tin ethyl etiopurpurin [SnET2]) commonly used in veterinary chemotherapy protocols was evaluated in 12 dogs with spontaneous tumors. To derive the photodynamic threshold dose, the tissue optical properties of each compound were determined by diffuse reflectance and thus the light fluence rate. Uptake was measured by fluorimetry using tissue solubilization techniques. The threshold values calculated were highest for AlClPc (irradiated 48 hours after administration). The radius of necrosis (4.00 to 5.48 mm) and photosensitizer uptake (3.4 to 6.91 microg/g) were elevated after injection of porfimer sodium. The threshold dose model described here is photosensitizer dependent but independent of photosensitizer uptake and light dose. This study indicates that more photon absorption is needed for tumor necrosis with AlClPc than for either SnET2 or porfimer sodium.  相似文献   

Serum and Synovial Fluid Serum Amyloid A Response in Equine Models of Synovitis and Septic Arthritis          下载免费PDF全文

Elsa K. Ludwig  R. Brandon Wiese  Megan R. Graham  Amelia J. Tyler  Julie M. Settlage  Stephen R. Werre  Christina S. Petersson‐Wolfe  Isis Kanevsky‐Mullarky  Linda A. Dahlgren 《Veterinary surgery : VS》2016,45(7):859-867

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IMAGING DIAGNOSIS — UNILATERAL TRIGEMINAL NEURITIS MIMICKING PERIPHERAL NERVE SHEATH TUMOR IN A HORSE          下载免费PDF全文

Elsa Beltran  Rachael Grundon  Jennifer Stewart  Marianna Biggi  Andrew Holloway  Courtenay Freeman 《Veterinary radiology & ultrasound》2016,57(1):E1-E4

A 16‐year old Warmblood gelding presented with a nonhealing corneal ulcer and absent corneal sensation in the left eye. A lesion affecting the maxillary and ophthalmic branches of the left trigeminal nerve was suspected. Magnetic resonance (MR) imaging identified marked thickening of the ophthalmic and maxillary branches of the left trigeminal nerve. The nerve was iso‐ to hypointense on T1‐weighted and T2‐weighted images with heterogeneous enhancement. A peripheral nerve sheath tumor was suspected, however granulomatous neuritis was histopathologically confirmed. These inflammatory changes can result in severe nerve enlargement and should be considered with MR findings suggestive of peripheral nerve sheath tumor.  相似文献   

Melanaspis corticosa: a new insect pest of olive trees in Europe     

Mazzeo  Gaetana  Pellizzari  Giuseppina  Mateus  Célia  da Silva  Elsa Borges  Russo  Agatino  Nucifora  Salvatore  Soares  Celestino  Tomé  Dora  de Andrade  Eugénia  Franco  José Carlos 《Phytoparasitica》2023,51(2):153-162

The presence of the South African Obscure Scale, Melanaspis corticosa (Brain) (Hemiptera, Diaspididae), was detected infesting olive trees, in Portugal. The identity of the scale insect was confirmed based on both morphological and molecular studies. Until now, this species was only known in a few African countries, including Guinea, Mozambique, South Africa and Zimbabwe. This is the first record of this species in Europe and in the Palearctic region. The scale was observed in 15 different locations, in the Algarve, since its first detection at the end of 2016. Samples were collected between 21 December 2016 and 10 March 2022, covering all seasonal periods. Most of the sampling sites resulted from private requests from farmers and proprietaries received by the Plant Protection Division of the Regional Directorate of Agriculture. Although it is considered a polyphagous species, it was not observed in other plant species, besides olive trees. The actual dispersion in the region suggests that M. corticosa became established and has been expanded its distribution since its arrival. This scale insect is a potential injurious pest of olive trees and needs to be studied to clarify its pest status and develop effective pest management strategies.

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Upper alimentary tract papillomas in calves related to papillomavirus infection     

Morris WE  Venzano AJ  Craig MI  Diodati JA  Funes D  Elizondo A  Mercado E  Capellino F  Delgado F  Blanco-Viera J 《The Canadian veterinary journal. La revue veterinaire canadienne》2010,51(8):877-880

This study reports 3 cases of spontaneous papillomavirus infection in 1-week-old calves. Thickening of the omasum and abomasum wall, with acute inflammation, necrosis, ulceration, and neoplastic changes were seen in 1 calf. In the other 2, small papillomas were observed in the omasal mucosa, exhibiting proliferation of the parakeratinized epithelium. Papillomavirus antigens were detected by immunohistochemistry and virus-like particles were seen through electron microscopy.  相似文献   

Genetic diversity of the pan‐European freshwater mussel Anodonta anatina (Bivalvia: Unionoida) based on CO1: new phylogenetic insights and implications for conservation          下载免费PDF全文

Elsa Froufe  Carina Sobral  Amílcar Teixeira  Ronaldo Sousa  Simone Varandas  David C. Aldridge  Manuel Lopes‐Lima 《水产资源保护:海洋与淡水生态系统》2014,24(4):561-574

Imaging diagnosis: pituitary apoplexy in a cat     

Beltran E  Dennis R  Foote A  De Risio L  Matiasek L 《Veterinary radiology & ultrasound》2012,53(4):417-419

A 7-year-old male neutered domestic short-haired cat had depression for 5 months and acute blindness. A lesion at the level of the rostral and middle cranial fossae was suspected. A large pituitary mass compressing the optic chiasm was detected in magnetic resonance images and there was also evidence of recent intratumoral hemorrhage, leading to a diagnosis of pituitary apoplexy; these findings were confirmed at postmortem examination. Pituitary apoplexy is a clinical syndrome characterized by acute neurologic signs related to hemorrhagic infarction within a pituitary tumor. Pituitary apoplexy should be considered in patients with acute onset of blindness and altered mental status.  相似文献   

Ultrastructural characteristics of Nematopsis sp. oocysts (Apicomplexa: Porosporidae), a parasite of the clam Meretrix meretrix (Veneridae) from the Arabian Gulf, Saudi Arabia     

Abdel-Baki AA  Al-Quraishy S  Dkhil MA  Al Nasr I  Oliveira E  Casal G  Azevedo C 《Folia parasitologica》2012,59(2):81-86

This paper describes the fine structure of oocysts of Nematopsis sp. (Apicomplexa, Porosporidae) found in the abductor muscles of seawater clams, Meretrix meretrix (Linnaeus, 1758) (Veneridae), collected near the city of Dammam (6 degrees 17'0"N, 50 degrees 12'0"E) in the Arabian Gulf off the coast of Saudi Arabia. Oocysts of an ellipsoidal shape were found among myofibrils of the abductor muscles of infected clams. Each oocyst is composed of an oocyst wall surrounding a single uninucleate vermiform sporozoite located in the lumen of the oocyst wall. The thin oocyst wall (0.70-0.85 microm thick) is composed of homogenous electron-lucent material formed by three layers of equal-thickness. The oocyst wall contains a plano-convex opercular-like structure about 2.5 microm in diameter and 0.75-0.90 microm thick, composed of a homogenous material with moderate electron density. The oocyst is of an ellipsoidal shape and is 15.6 +/- 0.6 microm long and 11.1 +/- 0.7 microm wide. Externally, the oocyst wall is surrounded by a complex dense network of numerous anastomosed microfibrils, which are attached to the oocyst wall, forming 2-3 layers and extending towards the periphery, at some points penetrating amongst the host cells. The myofibrils in some cases show evident aspects of lysis as a consequence of the appearance of lysosome-like vesicles. Lacking knowledge of a complete life cycle and/or molecular data precluded the conclusive identification of this species.  相似文献   

Neurological signs and MRI findings in 12 dogs with multiple myeloma     

Sophie Wyatt  Luisa De Risio  Colin Driver  Roberto Jos‐Lpez  Mauro Pivetta  Elsa Beltran 《Veterinary radiology & ultrasound》2019,60(4):409-415

Vertebral lesions and associated neurological signs occur in dogs with multiple myeloma, however, veterinary literature describing MRI findings is currently lacking. The objective of this multicenter, retrospective, case series study was to describe neurological signs and MRI findings in a group of dogs that presented for spinal pain or other neurological deficits and had multiple myeloma. Electronic records of four veterinary referral hospitals were reviewed. Dogs were included if they had a pathologically confirmed diagnosis of multiple myeloma, had presented for spinal pain or other neurological signs, and had undergone MRI of the vertebral column. The MRI studies were evaluated and the anatomical location of lesion(s), signal intensity, presence of extra‐dural material, degree of spinal cord compression, extent of vertebral lesions, and contrast enhancement were recorded. Twelve dogs met inclusion criteria. Most dogs (n = 8) had a chronic progressive history, with varying degrees of proprioceptive ataxia and paresis (n = 11), and spinal pain was a feature in all dogs. The MRI findings were variable but more consistent features included the presence of multiple expansile vertebral lesions without extension beyond the outer cortical limits of affected vertebrae, and associated extradural material causing spinal cord compression. The majority of lesions were hyper‐ to isointense on T2 (n = 12) and T1‐weighted (n = 8) sequences, with variable but homogeneous contrast‐enhancement (n = 12). These described MRI characteristics of multiple myeloma may be used to aid early identification and guide subsequent confirmatory diagnostic steps, to ultimately improve therapeutic approach and long‐term outcome.  相似文献   

Effect of storage on microcytosis observed in dogs with portosystemic vascular anomalies     

Goodfellow M  Papasouliotis K  Cue S  Crawford E  Hall E 《Research in veterinary science》2008,84(3):490-493

Microcytosis is a common laboratory finding in dogs with iron deficiency and congenital portosystemic vascular anomalies (PSVA), however artefactual changes due to blood storage may occur which could mask this feature. This study evaluated the effects of storage on microcytosis in dogs with congenital PSVA. Full haematological parameters were measured on the day of sampling and following 24h storage at room temperature, in unaffected dogs (n=13) and in dogs affected with PSVA (n=24). Storage for 24h resulted in significantly higher MCV values in both groups of dogs (P<0.01). The percentage increase in MCV was greater in the control dogs (median 8.07%, range 5.64-9.31%) compared to affected dogs (median 6.05%, range 3.12-15.21%) (P<0.02). Storage of 1ml EDTA blood samples at ambient temperature for 24h prior to analysis, as occurs when samples are posted to external laboratories, will have significant effects on MCV and may mask microcytosis in dogs with PSVA.  相似文献