Pulmonary Mycobacterium bovis infection in a dog     

Gay G  Burbidge HM  Bennett P  Fenwick SG  Dupont C  Murray A  Alley MR 《New Zealand veterinary journal》2000,48(3):78-81

AIM: To describe the clinical course of a dog infected with Mycobacterium bovis causing a granulomatous pneumonia. CLINICAL FINDINGS: The dog initially presented with a persistent cough, inappetence and weight loss. Clinical findings included a fever, dyspnoea and tachypnoea, with haematological evidence of a mild neutrophilia and hypoalbuminaemia. Radiographs of the chest demonstrated a concomitant pneumothorax, pleural effusion, and a consolidated area within the left caudal lung lobe. An exploratory thoracotomy revealed this to be a ruptured granulomatous lesion. Subsequent histopathological, microbiological and genetic studies identified M. bovis as the causal agent. CLINICAL SIGNIFICANCE: Mycobacterium bovis infections should be included in the differential diagnosis of pulmonary disease and pleural effusions in dogs living in regions of New Zealand known to have a high incidence of mycobacterial infection in wildlife and farm animals.  相似文献   

Overstory–understory biomass changes over a 35-year period in southcentral Oregon     

James M. Peek  Jerome J. Korol  Donald Gay  Terry Hershey   《Forest Ecology and Management》2001,150(3):267-277

Forest canopy development is known to influence understory biomass relationships. An 85,268 ha area in southcentral Oregon was examined for changes in overstory canopy closure using 1953 and 1988 aerial and satellite imagery and a geographic information system. A negative exponential curve predicted a loss of approximately half of understory biomass over the 35-year interval. Reductions in understory biomass were most pronounced at higher elevations where growing conditions for conifers and canopy closure changes were most pronounced. The loss of understory biomass was related to declines in mule deer (Odocoileus hemionus) populations in the area.  相似文献   

Fungal auxin overproduction affects the anatomy of Hebeloma cylindrosporum-Pinus pinaster ectomycorrhizas     

Laurans F  Pepin R  Gay G 《Tree physiology》2001,21(8):533-540

We studied the effect of fungal auxin overproduction on the growth polarity of cortical cells in pine mycorrhizas by comparing the anatomy of Pinus pinaster (Ait.) Sol. mycorrhizas formed by an IAA-overproducing mutant of Hebeloma cylindrosporum Romagnesi or by the corresponding wild type with non-mycorrhizal short roots. Both wild- type and mutant strains induced an increase in root diameter that was mostly a result of the influence of the fungus on root cortical development. Both strains affected growth polarity of P. pinaster cortical cells and induced a change in their shape. The main modifications were a large reduction in axial diameter and an increase in the radial diameter of the cortical cells. The modifications were more marked with the mutant than with the wild type. The mutant induced a 43% reduction in cortical cell elongation and a 35% increase in radial diameter, whereas the corresponding changes induced by the wild type were 30 and 10%, respectively. The volume of cortical cells in mature mycorrhizas was generally lower than in uninoculated short roots indicating that wild-type and mutant strains induced a reorientation of cortical cell growth but did not induce an increase in turgor pressure of the cells. Immunolocalization allowed visualization of alpha-tubulin in root cortical cells, but no obvious modification in alpha-tubulin distribution was detected as a consequence of symbiosis establishment. Likewise, cytochemical localization of polysaccharides in cortical cell walls did not show significant modification following symbiosis establishment and Hartig net formation. The only noticeable modification was a reduction in cortical cell wall thickness in mycorrhizas compared with uninoculated short roots. The possible involvement of fungal auxin in the observed modifications is discussed.  相似文献   

Prenatal immunization against experimental enteric colibacillosis in piglets.          下载免费PDF全文

C C Gay 《Canadian journal of veterinary research》1979,43(3):237-242

To establish a model for the study of prenatal immunization against enteric colibacillosis a proportion of the litters of seven sows were immunized in utero 18 to 22 days before term by intra-amniotic and intramuscular injection of Escherichia coli antigen and the litters challenged at birth with either homologous or heterologous strains. Protection against homologous challenge was demonstrated in some but not all vaccinated piglets. The study was severely compromised by the occurrence of intrauterine death in a significant proportion of vaccinated piglets.  相似文献   

Effects of trimethoprim-sulfadiazine on thyroid function of horses     

Rothschild CM  Hines MT  Breuhaus B  Gay J  Sellon DC 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2004,18(3):370-373

Trimethoprim-sulfadiazine was administered to horses in a randomized, placebo controlled study to determine the effects of potentiated sulfonamides on thyroid function in normal horses. The treatment group included eight horses that received trimethoprim-sulfadiazine mixed with molasses orally at 30 mg/kg once daily for eight weeks. The control group included 8 horses that received an oral placebo (flour mixed with molasses) once daily for the same period. Thyroid function was evaluated prior to initiation of treatment and after 8 weeks of treatment. Serum concentrations of total and free triiodothyronine (T3), total and free thyroxine (T4), and thyroid stimulating hormone (TSH) were determined at rest and after a thyrotropin-releasing hormone (TRH) stimulation test. There was no detectable difference between treatment and control groups.  相似文献   

Comparison of plasma disposition of alkaloids after lupine challenge in cattle that had given birth to calves with lupine-induced arthrogryposis or clinically normal calves     

Gay CC  Panter KE  Mealey KL  Gay JM  Hjartarson SW  Tibary A  Motteram ES  Wierenga T  James LF 《American journal of veterinary research》2004,65(11):1580-1583

OBJECTIVE: To compare plasma disposition of alkaloids after lupine challenge in cattle that had given birth to calves with lupine-induced arthrogryposis and cattle that had given birth to clinically normal calves and determine whether the difference in outcome was associated with differences in plasma disposition of anagyrine. ANIMALS: 6 cows that had given birth to calves with arthrogryposis and 6 cows that had given birth to clinically normal calves after being similarly exposed to lupine during pregnancy. PROCEDURES: Dried lupine (2 g/kg) was administered via gavage. Blood samples were collected before and at various time points for 48 hours after lupine administration. Anagyrine, 5,6-dehydrolupanine, and lupanine concentrations in plasma were measured by use of gas chromatography. Plasma alkaloid concentration versus time curves were generated for each alkaloid, and pharmacokinetic parameters were determined for each cow. RESULTS: No significant differences in area under the plasma concentration versus time curve, maximum plasma concentration, time to reach maximum plasma concentration, and mean residence time for the 3 alkaloids were found between groups. CONCLUSIONS AND CLINICAL RELEVANCE: Because no differences were found in plasma disposition of anagyrine following lupine challenge between cattle that had given birth to calves with arthrogryposis and those that had not, our findings do not support the hypothesis that between-cow differences in plasma disposition of anagyrine account for within-herd differences in risk for lupine-induced arthrogryposis.  相似文献   

ABCB1-1Delta polymorphism can predict hematologic toxicity in dogs treated with vincristine.     

K L Mealey  J Fidel  J M Gay  J A Impellizeri  C A Clifford  P J Bergman 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2008,22(4):996-1000

BACKGROUND: Dogs that harbor the naturally occurring ABCB1-1Delta polymorphism experience increased susceptibility to avermectin-induced neurological toxicosis as a result of deficient P-glycoprotein function. Whether or not the ABCB1-1Delta polymorphism affects susceptibility to toxicity of other P-glycoprotein substrate drugs has not been studied. HYPOTHESIS: Dogs that possess the ABCB1-1Delta mutation are more likely to develop hematologic toxicity associated with vincristine than ABCB1 wild-type dogs. ANIMALS: Thirty-four dogs diagnosed with lymphoma were included in this study. METHODS: Cheek swab samples were obtained from dogs diagnosed with lymphoma that were to be treated with vincristine. DNA was extracted from cheek swabs and the ABCB1 genotype was determined. Hematologic adverse drug reactions were recorded for each dog and graded according to the Veterinary Comparative Oncology Group's criteria for adverse event reporting (Consensus Document). In order to avoid possible bias, ABCB1 genotype results for a particular patient were not disclosed to oncologists until an initial adverse event report had been submitted. RESULTS: Dogs heterozygous or homozygous for the ABCB1-1Delta mutation were significantly more likely to develop hematologic toxicity, specifically neutropenia (P= .0005) and thrombocytopenia (P= .0001), after treatment with vincristine than ABCB1 wild-type dogs. CONCLUSIONS AND CLINICAL IMPLICATIONS: At currently recommended dosages (0.5-0.7 mg/M(2)), vincristine is likely to cause hematologic toxicity in dogs with the ABCB1-1Delta mutation, resulting in treatment delays and unacceptable morbidity and mortality. Assessing the ABCB1-1Delta genotype before vincristine administration and decreasing the dosage may prevent toxicity and treatment delays resulting from neutropenia or thrombocytopenia.  相似文献   

Antimicrobial resistance trends in Escherichia coli isolated from diseased food‐producing animals in France: A 14‐year period time‐series study          下载免费PDF全文

C. Boireau  É. Morignat  G. Cazeau  N. Jarrige  É. Jouy  M. Haenni  J.‐Y. Madec  A. Leblond  É. Gay 《Zoonoses and public health》2018,65(1):e86-e94

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LHYMO: A new Water Framework Directive-compliant multimetric index to assess lake hydromorphology and its application to French lakes     

Alexandra Carriere  Nathalie Reynaud  Aurore Gay  Jean-Marc Baudoin  Christine Argillier 《水产资源保护:海洋与淡水生态系统》2024,34(1):e4029

Forest structure in space: a case study of an old growth spruce-fir forest in Changbaishan Natural Reserve, PR China   总被引：1，自引：0，他引：1  

Jiquan Chen  Gay A. Bradshaw 《Forest Ecology and Management》1999,120(1-3):219-233

Ecologists and foresters are becoming increasingly aware of the importance of spatial information in ecosystem analysis and resource management. An across-scale analysis of forest structure was conducted to characterize the spatial characteristics of a 2 ha spruce-fir forest located inside Changbaishan Natural Reserve (CNR), PR China. The study was designed to develop an approach for assessment of within-stand heterogeneity to increase understanding of the effects of heterogeneity on pattern–process relationships in forests. Univariate and bivariate Ripley's K functions were employed to capture stand heterogeneity in terms of intra- and inter-specific point patterns of tree distributions. Stem-mapped crowns were generated and analyzed as canopy patches within a geographic information system (GIS) to quantify patterns within the strata of the forest canopy. The dominant spruces were randomly distributed within each height class but aggregated when all height classes were analyzed. In addition, spruces had repulsive patterns to other species which exhibited clear aggregation. Canopy heterogeneity, both in terms of composition and spatial patterning, were complex – as expressed within canopy layers and among individual forest species. This across-scale complexity supports a multivariate spatial and across-scale approach to characterizing forest structure, and argues for linked pattern-process experiments. We suggest that joint field and simulation studies be conducted which relate changes in forest stand dynamics to changes in stand heterogeneity. These linked studies are needed to provide a measure of ecological significance relative to statistical significance of patterns.  相似文献