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61.
Estimation of variance and genomic prediction using genotypes imputed from low‐density marker subsets for carcass traits in Japanese black cattle 下载免费PDF全文
Shinichiro Ogawa Hirokazu Matsuda Yukio Taniguchi Toshio Watanabe Yoshikazu Sugimoto Hiroaki Iwaisaki 《Animal Science Journal》2016,87(9):1106-1113
The influence of genotype imputation using low‐density single nucleotide polymorphism (SNP) marker subsets on the genomic relationship matrix (G matrix), genetic variance explained, and genomic prediction (GP) was investigated for carcass weight and marbling score in Japanese Black fattened steers, using genotype data of approximately 40,000 SNPs. Genotypes were imputed using equally spaced SNP subsets of different densities. Two different linear models were used. The first (model 1) incorporated one G matrix, while the second (model 2) used two different G matrices constructed using the selected and remaining SNPs. When using model 1, the estimated additive genetic variance was always larger when using all SNPs obtained via genotype imputation than when using only equally spaced SNP subsets. The correlations between the genomic estimated breeding values obtained using genotype imputation with at least 3,000 SNPs and those using all available SNPs without imputation were higher than 0.99 for both traits. While additive genetic variance was likely to be partitioned with model 2, it did not enhance the accuracy of GP compared with model 1. These results indicate that genotype imputation using an equally spaced low‐density panel of an appropriate size can be used to produce a cost‐effective, valid GP. 相似文献
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Miori Kishimoto Kazutaka Yamada Junichiro Shimizu Ki-Ja Lee Hirokazu Watarai Hany Y. Hassan Toshiroh Iwasaki Yoh-Ichi Miyake 《Veterinary research communications》2009,33(4):387-393
The purpose of the study reported here was to discuss the level of intelligibility of three-dimensional computed tomography
(3D-CT) images of clinical patients for persons who are lacking veterinary knowledge. 143 undergraduate students were participated
in this study. They were entirely unfamiliar with veterinary anatomy. A survey was conducted using the visual analog scale
method with a focus on the level of intelligibility of the 3D-CT images compared to that of the two-dimensional CT images
or radiographs. As a result, the mean value of the intelligibility of the 3D-CT image was 88.4 ± 17.8 points out of 100 points.
In clinical cases, it is very difficult for pet owners lacking veterinary knowledge to understand the clinical status of their
pets even with explanations using illustrations, radiographs, and transverse CT images. It is considered that better informed
consent and patient satisfaction will be obtained provided veterinarians make an effort towards intelligible patient education
by using 3D-CT images. 相似文献
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The hybrid vigor typical of F1 cultivars is used to boost biomass production of sorghum (Sorghum bicolor (L.) Moench). The high dry-matter yielding F1 cultivar Kazetachi uniquely shows extremely late flowering and a long culm, and is greatly different from its parents. We investigated the genetic mechanisms underlying these phenotypes by quantitative trait locus (QTL) analysis of recombinant inbred lines derived from a male-fertile line and a restorer line and grown in 3 years. QTL analysis for six traits (days-to-heading, culm length, culm width, culm number, panicle length, panicle number) revealed that the unique phenotypes of the F1 plants were controlled by the genetic combination of 12 or more QTLs detected in at least 2 years. Two putative QTLs for days-to-heading (qDH1 on SBI-01 and qDH6 on SBI-06) would strongly affect the other phenotypes because of their co-localization with QTLs for other traits, as supported by significant phenotypic correlations. These QTLs would be useful for understanding the association of plant type with biomass production in sorghum. 相似文献
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Quantitative trait loci for whiteness of cooked rice detected in improved rice cultivars in Hokkaido
Hiroshi Shinada Toshio Yamamoto Eiji Yamamoto Kiyosumi Hori Yuji Hirayama Toshihiko Maekawa Hitoshi Kiuchi Hirokazu Sato Takashi Sato 《Breeding Science》2015,65(3):201-207
Improving the eating quality of cooked rice has been one of the most important objectives in rice breeding programs. Eating quality of cooked rice is a complex trait including several components, such as external appearance, taste, aroma, and texture. Therefore, dissection of these components followed by marker-assisted selection of detected QTL(s) may be a useful approach for achieving desirable eating quality in rice breeding. Whiteness of cooked rice (WCR) is an important factor related to the external appearance of cooked rice. WCR is known to be associated with the amylose and protein contents of the endosperm. However, the genetic basis of WCR remains unclear. In this study, we evaluated phenotypic variation in WCR among recently developed rice cultivars from Hokkaido, Japan. Then, we developed doubled haploid lines (DHLs) derived from a cross between two cultivars from Hokkaido, Joiku No. 462 (high WCR) and Jokei06214 (low WCR). Using the DHLs, we detected two QTLs for WCR, qWCR3 and qWCR11, on chromosomes 3 and 11, respectively. We also examined the dosage effect of the two QTLs based on both the categorized segregants in the DHLs and the relationship between the WCR phenotype and inheritance around the QTL regions in cultivars from Hokkaido. 相似文献
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Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/d-galactosamine-induced liver injury 总被引:3,自引:0,他引:3
Morita T Jinno K Kawagishi H Arimoto Y Suganuma H Inakuma T Sugiyama K 《Journal of agricultural and food chemistry》2003,51(6):1560-1565
To evaluate the hepatoprotective activity of spices, 21 different spices were fed to rats with liver damage caused by lipopolysaccharide (LPS) plus d-galactosamine (D-GalN). As assessed by plasma aminotranferase activities, nutmeg showed the most potent hepatoprotective activity. Bioassay-guided isolation of the active compound from nutmeg was carried out in mice by a single oral administration of the respective fractions. Myristicin, one of the major essential oils of nutmeg, was found to possess extraordinarily potent hepatoprotective activity. Myristicin markedly suppressed LPS/D-GalN-induced enhancement of serum TNF-alpha concentrations and hepatic DNA fragmentation in mice. These findings suggest that the hepatoprotective activity of myristicin might be, at least in part, due to the inhibition of TNF-alpha release from macrophages. However, further studies are needed to elucidate the hepatoprotective mechanism(s) of myristicin. 相似文献
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A plant growth regulator, theobroxide, which produces potato tubers under noninduced long-day conditions, was synthesized in four steps from dihydrotoluene. 相似文献
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Nakamura A Yoshida R Maeda H Furuta H Corredig M 《Journal of agricultural and food chemistry》2004,52(17):5506-5512
The objective of this work was to investigate the role played by the protein fraction of soy soluble polysaccharide (SSPS) during its adsorption at oil/water interfaces. SSPS was separated in a high (HMF; 310 kDa) and low (LMF; 20 kDa) molecular weight fraction by gel filtration. SSPS/HMF consisted of 91.6% carbohydrate and 2.2% protein and showed better emulsifying properties than those of the whole SSPS, whereas SSPS/LMF seemed to affect negatively the adsorption behavior of SSPS. SDS-PAGE of the protein fraction obtained from SSPS/HMF showed a molecular mass of 50 kDa, was composed predominantly of proline (23.1%) and glutamic acid (15.2%), and still contained 8.8% of neutral sugar and 5.3% of uronic acid. Results indicated that not all of the protein material present in SSPS contributes to SSPS functionality but that only the material associated with HMF aids in the adsorption of SSPS onto oil/water interfaces. 相似文献
70.
Chisato YONEMOCHI Hirokazu FUJISAKI Chisato HARADA Toyoko KUSAMA Michito HANAZUMI 《Animal Science Journal》2002,73(3):221-228
The influence of transgenic event CBH 351 (StarLink; SL)-derived hybrid corn on the growth performance, health condition and physiological function in broiler chicks, as well as the possible transfer of the cry9C gene and Cry9C protein to blood, liver and muscle were examined in comparison with chicks fed on a diet with non-transgenic corn (SL-F). Bodyweight gain and feed conversion ratio in the chicks fed on a diet with SL were significantly greater than in chicks fed on a diet with SL-F during the starter phase (0–3 weeks of age), but this significant difference disappeared during the finisher phase (4–7 weeks of age). No abnormalities in health condition in either SL or SL-F groups were observed, and livability did not differ significantly between SL and SL-F groups. Moreover, no significant differences in serum biochemical and hematological values, histopathological observation and necropsy findings were observed between SL and SL-F groups at the end of the experiment. The cry9C gene and Cry9C protein were not detected in blood, liver and muscle of chicks at 3, 5 or 7 weeks of age. The results indicate that feeding SL does not influence growth performance, health condition or physiological function in broiler chicks, and the cry9C gene and Cry9C protein are not transferred to the blood, liver and muscles of broilers. 相似文献