4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells     

Peeraporn Varinthra  Shun-Ping Huang  Supin Chompoopong  Zhi-Hong Wen  Ingrid Y. Liu 《Marine drugs》2021,19(1)

Age-related macular degeneration (AMD) is a progressive eye disease that causes irreversible impairment of central vision, and effective treatment is not yet available. Extracellular accumulation of amyloid-beta (Aβ) in drusen that lie under the retinal pigment epithelium (RPE) has been reported as one of the early signs of AMD and was found in more than 60% of Alzheimer’s disease (AD) patients. Extracellular deposition of Aβ can induce the expression of inflammatory cytokines such as IL-1β, TNF-α, COX-2, and iNOS in RPE cells. Thus, finding a compound that can effectively reduce the inflammatory response may help the treatment of AMD. In this research, we investigated the anti-inflammatory effect of the coral-derived compound 4-(phenylsulfanyl) butan-2-one (4-PSB-2) on Aβ_1-42 oligomer (oAβ_1-42) added to the human adult retinal pigment epithelial cell line (ARPE-19). Our results demonstrated that 4-PSB-2 can decrease the elevated expressions of TNF-α, COX-2, and iNOS via NF-κB signaling in ARPE-19 cells treated with oAβ_1-42 without causing any cytotoxicity or notable side effects. This study suggests that 4-PSB-2 is a promising drug candidate for attenuation of AMD.  相似文献   

Evaluation of DRAINMOD using saturated hydraulic conductivity estimated by a pedotransfer function model   总被引：1，自引：0，他引：1  

Osvaldo Salazar  Ingrid Wesström 《Agricultural Water Management》2008,95(10):1135-1143

Direct measurement of soil saturated hydraulic conductivity (K_s) is time-consuming and therefore costly. The ROSETTA pedotransfer function model is able to estimate K_s from soil textural data, bulk density and one or two water retention points. This study evaluated the feasibility of running the DRAINMOD field-scale hydrological model with K_s input produced using ROSETTA. A hierarchical approach was adopted to estimate K_s using ROSETTA, with four limited-more extended sets of soil information used as inputs: USDA textural class (H1); texture (H2); texture and bulk density (H3); texture, bulk density, water retention at −33 kPa (θ_33 kPa) and −1500 kPa (θ_1500 kPa) (H4). ROSETTA-estimated K_s values from these four groups (H1-H4) were used in DRAINMOD to simulate drain outflows during a 4-year period from a conventional drainage plot (CD) and two controlled drainage plots (CWT1 and CWT2) located in south-east Sweden. The DRAINMOD results using ROSETTA-estimated K_s values were compared with observed values and with model results using laboratory-measured K_s values (H0). Deviations in simulated drainage outflow (D), infiltration (F) and evapotranspiration (ET) resulting from the use of ROSETTA-estimated rather than laboratory-measured K_s values were evaluated. During the study period, statistical comparisons showed good agreement on a monthly basis between observed and DRAINMOD-simulated drainage rates using five soil datasets (H0, H1, H2, H3 and H4). The monthly mean absolute error (MAE) ranged from 0.57 to 0.82 cm for CD, 0.38 to 0.41 cm for CWT1, and 0.15 to 0.22 cm for CWT2. On a monthly basis, the modified coefficient efficiency (E′) values were in the range of 0.62 to 0.74 for CD, 0.72 to 0.74 for CWT1, and 0.79 to 0.86 for CWT2. The modified index of agreement (d′) for monthly predictions ranged from 0.80 to 0.86 cm for CD, 0.87 to 0.88 cm for CWT1, and 0.89 to 0.93 cm for CWT2. The absolute values of the percent-normalised error (NE) on an overall basis when using ROSETTA-estimated rather than laboratory-measured K_s values were less than 3% in E, less than 1% in F, and less than 15% in D. The results suggest that ROSETTA-estimated K_s values can be used in DRAINMOD to simulate drainage outflows as accurately as laboratory-measured K_s values (H0) in coarse-textured soils.  相似文献   

MAGNETIC RESONANCE IMAGING OF THE NORMAL AND DISEASED FELINE MIDDLE EAR     

Ingrid  Allgoewer  DVM  Susanne  Lucas  DVM  Stephan Albert  Schmitz  MD 《Veterinary radiology & ultrasound》2000,41(5):413-418

The magnetic resonance imaging appearance of the feline middle ear is described in three healthy cats and in five cats with middle ear disease. Owing to the good spatial resolution, multiplanar slice orientation as well as display high contrast resolution of soft tissue, in particular fluids, MR imaging was helpful prior to surgery. It is superior to radiography which failed to allow identification of the abnormality in two of our five cats. MR imaging for middle ear disease should include dorsal and transverse plane images using T1- and T2-weighted sequences. In the presence of a mass within the bulla or the external ear canal application of contrast medium is helpful.  相似文献   

Corrigendum to ‘Interference of iohexol with radioiodine thyroid uptake in the hyperthyroid cat’ [Journal of Feline Medicine and Surgery 10, 460–465]     

Kathelijne Peremans DVM  DipECVDI  PhD  Eva Vandermeulen DVM  Ingrid van Hoek DVM  Sylvie Daminet DVM  DipECVIM  PhD  Simon Vermeire DVM  Klaus Bacher PhD 《Journal of Feline Medicine and Surgery》2008,10(6)

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Efficacy of Two Radiologic‐Assisted Prophylactic Gastropexy Techniques          下载免费PDF全文

Ingrid M. Balsa  William T. N. Culp  Eric G. Johnson  Craig B. Glaiberman  Millie Grimes  Philipp D. Mayhew  Carrie A. Palm 《Veterinary surgery : VS》2016,45(4):464-470

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Description and Biomechanical Comparison of a Percutaneous Radiologic Gastropexy Technique in a Canine Cadaver Model          下载免费PDF全文

William T. N. Culp  Ingrid M. Balsa  Sun Y. Kim  Craig B. Glaiberman  Millie Grimes  Philipp D. Mayhew  Eric G. Johnson  Carrie A. Palm  Tanya C. Garcia  Philip H. Kass 《Veterinary surgery : VS》2016,45(4):456-463

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Comparison between real‐time 3‐dimensional and 2‐dimensional biplane echocardiographic assessment of left atrial volumes in dogs with myxomatous mitral valve disease     

Anna Tidholm  Anna Bodegrd‐Westling  Katja Hglund  Jens Hggstrm  Ingrid Ljungvall 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(2):455-461

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Perioperative morbidity and mortality in dogs with invasive adrenal neoplasms treated by adrenalectomy and cavotomy     

Philipp D. Mayhew  Sarah E. Boston  Allison L. Zwingenberger  Michelle A. Giuffrida  Jeffrey J. Runge  David E. Holt  Joseph S. Raleigh  Ameet Singh  William T. N. Culp  J. Brad Case  Michele A. Steffey  Ingrid M. Balsa 《Veterinary surgery : VS》2019,48(5):742-750

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Assessing biogas digestate,pot ale,wood ash and rockdust as soil amendments: effects on soil chemistry and microbial community composition     

Atefeh Ramezanian  Colin D. Campbell  Stephen Hillier  Ingrid Öborn 《Acta Agriculturae Scandinavica, Section B - Plant Soil Science》2013,63(5):383-399

Applying by-products as soil amendments to agricultural systems is growing in popularity. We aimed to assess the efficacy of some contemporary by-products to provide nutrients to crops as well as the potential harm of adding toxic elements to the environment. Four different by-products widely available in Northern Europe were tested for their effects on two nutrient-poor agricultural soils in terms of increasing available macro- and micro-nutrients as well as toxic elements. Assessing soil microbial community as a sensitive tool for evaluating soil quality was conducted with the focus on microbial activity, carbon metabolism and on Rhizobium/Agrobacterium. Wood ash increased pH and Ca_EDTA, K_EDTA and Mg_EDTA in the soils. The only increase in EDTA-extractable micronutrients in the soils was observed by applying pot ale, increasing Cu. None of the amendments increased the availability of Pb and Cd in the soils. Soils amended with the by-products thus remained similar to the unamended control but were quite different from fully mineral fertilised soils. There were no detectable adverse effects on the physiological and genetic profiles of microbial communities. The by-products were moderately beneficial and did not change the soil microbial community as much as the fully fertilised treatment with mineral fertilisers. Changes in the microbial community profiles were probably due to direct effects on microbes limited by K, Ca and N as opposed to indirect effects on plant growth. This is potentially significant in understanding how to improve impoverished and marginal soils as microbial activity affects many other ecosystem functions.  相似文献   

Embryonic development in corkwing wrasse,Symphodus melops     

Enrique Blanco Gonzalez  Ingrid Torstensnes  Mana Naito 《Journal of the World Aquaculture Society》2019,50(5):993-1001

Corkwing wrasse, Symphodus melops, is one of the main species used as cleaner fish to combat sea lice infestation in salmon aquaculture; however, there is little knowledge about its biology. Here, we describe the embryonic development of this species and examine the viability of the eggs under three temperature regimes. The experiments were conducted at three water temperature regimes, 12, 15, and 18°C, which resemble common sea water temperatures registered during the spawning season of corkwing wrasse at different latitudes along the Norwegian coast. Corkwing wrasse spawn small spherical eggs of 0.75–0.80 mm in diameter (mean 0.78, CV = 3.6%) with several oil droplets and go through eight developmental stages until hatching. The shortest hatching time was registered after 144 hr at 18°C and after 222 and 372 hr at 15 and 12°C, respectively. These observations provide important baseline biological information to advance the establishment of commercial rearing techniques and sustainable fishing management practices for this heavily exploited species.  相似文献