Public health. 911.gov   总被引：1，自引：0，他引：1  

Shneiderman B  Preece J 《Science (New York, N.Y.)》2007,315(5814):944

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Genomics. Consensus emerges on HapMap strategy     

Couzin J 《Science (New York, N.Y.)》2004,304(5671):671-673

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Cancer immunotherapy. Select T cells,given space,shrink tumors     

Couzin J 《Science (New York, N.Y.)》2002,297(5589):1973

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A role for the phagosome in cytokine secretion     

Murray RZ  Kay JG  Sangermani DG  Stow JL 《Science (New York, N.Y.)》2005,310(5753):1492-1495

Membrane traffic in activated macrophages is required for two critical events in innate immunity: proinflammatory cytokine secretion and phagocytosis of pathogens. We found a joint trafficking pathway linking both actions, which may economize membrane transport and augment the immune response. Tumor necrosis factor alpha (TNFalpha) is trafficked from the Golgi to the recycling endosome (RE), where vesicle-associated membrane protein 3 mediates its delivery to the cell surface at the site of phagocytic cup formation. Fusion of the RE at the cup simultaneously allows rapid release of TNFalpha and expands the membrane for phagocytosis.  相似文献   

Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes     

Gardner MJ  Bishop R  Shah T  de Villiers EP  Carlton JM  Hall N  Ren Q  Paulsen IT  Pain A  Berriman M  Wilson RJ  Sato S  Ralph SA  Mann DJ  Xiong Z  Shallom SJ  Weidman J  Jiang L  Lynn J  Weaver B  Shoaibi A  Domingo AR  Wasawo D  Crabtree J  Wortman JR  Haas B  Angiuoli SV  Creasy TH  Lu C  Suh B  Silva JC  Utterback TR  Feldblyum TV  Pertea M  Allen J  Nierman WC  Taracha EL  Salzberg SL  White OR  Fitzhugh HA  Morzaria S  Venter JC  Fraser CM  Nene V 《Science (New York, N.Y.)》2005,309(5731):134-137

We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated.  相似文献   

Global mapping of the yeast genetic interaction network   总被引：1，自引：0，他引：1  

Tong AH  Lesage G  Bader GD  Ding H  Xu H  Xin X  Young J  Berriz GF  Brost RL  Chang M  Chen Y  Cheng X  Chua G  Friesen H  Goldberg DS  Haynes J  Humphries C  He G  Hussein S  Ke L  Krogan N  Li Z  Levinson JN  Lu H  Ménard P  Munyana C  Parsons AB  Ryan O  Tonikian R  Roberts T  Sdicu AM  Shapiro J  Sheikh B  Suter B  Wong SL  Zhang LV  Zhu H  Burd CG  Munro S  Sander C  Rine J  Greenblatt J  Peter M  Bretscher A  Bell G  Roth FP  Brown GW  Andrews B  Bussey H  Boone C 《Science (New York, N.Y.)》2004,303(5659):808-813

A genetic interaction network containing approximately 1000 genes and approximately 4000 interactions was mapped by crossing mutations in 132 different query genes into a set of approximately 4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and similar patterns of interactions tended to identify components of the same pathway. The genetic network exhibited dense local neighborhoods; therefore, the position of a gene on a partially mapped network is predictive of other genetic interactions. Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms.  相似文献   

Global-scale similarities in nitrogen release patterns during long-term decomposition   总被引：2，自引：0，他引：2  

Parton W  Silver WL  Burke IC  Grassens L  Harmon ME  Currie WS  King JY  Adair EC  Brandt LA  Hart SC  Fasth B 《Science (New York, N.Y.)》2007,315(5810):361-364

Litter decomposition provides the primary source of mineral nitrogen (N) for biological activity in most terrestrial ecosystems. A 10-year decomposition experiment in 21 sites from seven biomes found that net N release from leaf litter is dominantly driven by the initial tissue N concentration and mass remaining regardless of climate, edaphic conditions, or biota. Arid grasslands exposed to high ultraviolet radiation were an exception, where net N release was insensitive to initial N. Roots released N linearly with decomposition and exhibited little net N immobilization. We suggest that fundamental constraints on decomposer physiologies lead to predictable global-scale patterns in net N release during decomposition.  相似文献   

Induced pluripotent stem cell lines derived from human somatic cells   总被引：10，自引：0，他引：10  

Yu J  Vodyanik MA  Smuga-Otto K  Antosiewicz-Bourget J  Frane JL  Tian S  Nie J  Jonsdottir GA  Ruotti V  Stewart R  Slukvin II  Thomson JA 《Science (New York, N.Y.)》2007,318(5858):1917-1920

Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an undifferentiated state. We show that four factors (OCT4, SOX2, NANOG, and LIN28) are sufficient to reprogram human somatic cells to pluripotent stem cells that exhibit the essential characteristics of embryonic stem (ES) cells. These induced pluripotent human stem cells have normal karyotypes, express telomerase activity, express cell surface markers and genes that characterize human ES cells, and maintain the developmental potential to differentiate into advanced derivatives of all three primary germ layers. Such induced pluripotent human cell lines should be useful in the production of new disease models and in drug development, as well as for applications in transplantation medicine, once technical limitations (for example, mutation through viral integration) are eliminated.  相似文献   

Fighting algae in Kaneohe Bay     

Goreau TJ  Smith JE  Conklin EJ  Smith CM  Hunter CL 《Science (New York, N.Y.)》2008,319(5860):157

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Developmental biology. Purified signaling protein stimulates stem cell proliferation     

Couzin J 《Science (New York, N.Y.)》2003,300(5620):722

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