Honey from plants containing pyrrolizidine alkaloids: a potential threat to health     

Edgar JA  Roeder E  Molyneux RJ 《Journal of agricultural and food chemistry》2002,50(10):2719-2730

Following scientific risk assessments, several countries have imposed strict regulations on herbal medicines containing 1,2-dehydro-pyrrolizidine alkaloids. Using published data on the plants used in honey production, pyrrolizidine alkaloid-containing plants are shown in this review to represent a significant source of honey worldwide. This observation, honey consumption data, reported levels of pyrrolizidine alkaloids in honeys, and consideration of tolerable exposure levels determined for pyrrolizidine alkaloids in herbal medicines, leads to the conclusion that some honey is a potential threat to health, especially for infants and fetuses, and further investigation is warranted.  相似文献   

Antioxidant capacity of different broccoli (Brassica oleracea) genotypes using the oxygen radical absorbance capacity (ORAC) assay     

Kurilich AC  Jeffery EH  Juvik JA  Wallig MA  Klein BP 《Journal of agricultural and food chemistry》2002,50(18):5053-5057

Antioxidant capacity of hydrophilic and lipophilic extracts from eight broccoli genotypes was compared using the oxygen radical absorbance capacity (ORAC) assay. Each genotype was analyzed for carotenoid, tocopherol, ascorbic acid, and flavonoid content. Results indicate that the antioxidant capacity of hydrophilic extracts ranged from 65.8 to 121.6 micromol trolox equivalents (TE)/g of tissue, and the capacity of lipophilic extracts ranged from 3.9 to 17.5 micromol TE/g. Ascorbic acid and flavonoid content of the hydrophilic extracts did not explain the total variation in antioxidant capacity of those extracts, suggesting either the presence of other antioxidant components that have yet to be identified or that the known antioxidants are producing synergistic effects. The carotenoids did correlate with antioxidant capacity of the lipophilic extracts and accounted for the majority of the variability in that fraction. The variability in hydrophilic and lipophilic antioxidant capacity found among these genotypes suggests that potential efficacy from antioxidants will vary considerably from genotype to genotype.  相似文献   

Antiproliferative activities of citrus flavonoids against six human cancer cell lines   总被引：14，自引：0，他引：14  

Manthey JA  Guthrie N 《Journal of agricultural and food chemistry》2002,50(21):5837-5843

Citrus fruits contain high concentrations of several classes of phenols, including numerous hydroxycinnamates, flavonoid glycosides, and polymethoxylated flavones. The latter group of compounds occurs without glycosidic linkages and has been shown to inhibit the proliferation of a number of cancer cell lines. This antiproliferative property was further demonstrated against additional human cancer cell lines, and the antiproliferative actions of a series of synthetic methoxylated flavones were also studied. Similar to the naturally occurring compounds, the synthetic compounds exhibited strong antiproliferative activities. In many cases the IC(50) values occurred below 10 microm. Other hydroxylated flavone and flavanone aglycons also exhibited antiproliferative activities against the cancer cell lines, with the flavones showing greater activities than the flavanones. Glycosylation of these compounds removed their activity. The strong antiproliferative activities of the polymethoxylated flavones suggest that they may have use as anticancer agents in humans.  相似文献   

Differentiation of physical from chemical toxicity in solid waste fish bioassays     

Peter M. Chapman  J. David Popham  Jack Griffin  David Leslie  John Michaelson 《Water, air, and soil pollution》1987,33(3-4):295-308

This study showed that particulate (i.e., physical) toxicity was responsible for rainbow trout deaths in bioassays with two separate solid wastes. This conclusion was based on: (1) fish necropsies which indicated physical damage to gills but no evidence of chemical damage to liver or kidney, (2) chemical analyses which indicated that levels of Priority Pollutants and other target compounds were too low to cause the observed toxicity, (3) structural and chemical analyses of the waste particles which showed that these consisted of inert materials, and (4) the use of centrifugation techniques to remove most of the suspended particulate material in bioassay tanks resulting in an elimination of most of the toxicity. The particles associated with the lethal effects were approximately 5 to 10 μm in size. Regulatory testing of solid wastes must distinguish physical and chemical toxicity since disposal options can vary depending on the mode of toxicity. For instance, chemical toxicity raises concern regarding leaching through soils into groundwater, whereas if physical particles are responsible for toxicity, such leaching is not of concern.  相似文献   

Quantitative relationships between morphology and current soil hydrology in some Alfisols in semiarid tropical Australia     

Ross J. Coventry  John Williams 《Geoderma》1984,33(3):191-218

The shallow groundwater hydrology of a sequence of red, yellow, and grey earths (Paleustalfs, Plinthustalfs and Ochraqualfs of “Soil Taxonomy”) was monitored over a 9-year period (1973–1982) along a drilled transect of 30 boreholes near Torrens Creek, in northeastern Australia. Climatic analysis shows an aridic soil moisture regime under which soil water surpluses should not occur, and thus significant hydromorphism would not be expected in the soils. The present study has demonstrated, however, that profile saturation and groundwater tables may be expected to develop at various depths in the soils as often as 1 year in 3. Besides, strong linear relationships were found between a number of morphological features of the soils and various hydrological regimes currently active in the profiles: the depths to the upper limits of brown, brownish red, or red mottles, to the upper limit of ironstone gravels, and to the maximum content of clay are all most closely related to the mean position of the shallowest water tables observed; the depths to grey mottles and to mottles with chromas of two or less are most directly related to the depths at which the soils are saturated for 5 weeks; the depth to the maximum content of ironstone gravels and to the base of the solum are most closely associated with the depth at which the soils are saturated for 10 to 15 weeks; and dominantly grey colours in the strongly mottled subsols are best related to profile saturations for at least 21 weeks. The results indicate that the gley features present in the soil profiles could have developed, at least in part, in response to the current soil hydrological regime.  相似文献   

Toxicity of lead nitrate to algae     

John L. Malanchuk  Gerhard K. Gruendling 《Water, air, and soil pollution》1973,2(2):181-190

The fixation of radioactive C was used to mesaure the toxicity of Pb(NO₃)₂ to five species of freshwater algae. Portions of unialgal cultures were inoculated into low salt medium and were used to test all species at 10, 20 and 30 ppm Pb. This medium approximated the salt concentrations of natural aquatic environments. Three different cell weights were used for each concentration of Pb and for the control to determine a relationship between cell weight and toxicity. The concentration of Pb causing a 50% reduction of¹⁴CO₂ fixation as compared to the control was called the ED₅₀ (median effective dose). These values were extrapolated from graphs of ppm Pb vs dpm mg^?1 dry cell weight. The ED₅₀ for three of the species tested (Anabaena, Chlamydomonas andNavicula) was between 15 and 18 ppm Pb. A desmid,Cosmarium, had an ED₅₀ of 5 ppm. This species has a higher surface: volume ratio than the other species tested and this may account for its increased sensitivity. An ED₅₀ forOchromonas was not obtained. Throughout this experiment the fixation of¹⁴CO₂ increased with increasing Pb concentrations and is not readily explained.  相似文献   

Intermediate mixing of thermal discharges into a uniform current     

John Eric Edinger  Edward M. Polk Jr. 《Water, air, and soil pollution》1971,1(1):7-31

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Effects of increasing acidity on aquatic protozoan communities     

B. R. Niederlehner  John Cairns Jr. 《Water, air, and soil pollution》1990,52(1-2):183-196

Laboratory tests were conducted to evaluate the chronic effects of increased acidity on protozoan communities. Taxonomic richness of the protozoan component of these communities was severely affected at pH ≤ 5.33. Taxonomic composition was significantly affected at much higher pH. A permissible concentration was defined as the pH affecting no more than 20% of the species and estimated from concentration-response regression as 6.92 (5.92 to 8.04) pH units. A similar value estimated from more conventional chronic toxicity tests was 6.28 (6.16 to 6.45) pH units. Bacterial abundance decreased at pH levels ≤ 5.34 pH units. Other nontaxonomic responses (e.g., biomass, algal biomass, fungal biomass, net oxygen metabolism) were not sensitive to increases in acidity.  相似文献   

Ionic composition of acid lakes in relation to airborne inputs and watershed characteristics     

Gary E. Glass  John A. Sorensen  Barbara W. Liukkonen  George R. Rapp Jr.  Orie L. Loucks 《Water, air, and soil pollution》1986,31(1-2):1-15

Present acid forming emissions to the atmosphere have the potential to alter significantly the chemistry of rain, snow, and surface water of weakly buffered lakes in the Upper Midwest. Average precipitation pH from field measurements during 1979–1983 declined from west to east from 4.8, 4.6, and 4.3 along a cross-section of sites in Minnesota, Wisconsin, and Michigan respectively where 990 lake and stream sampling sites were studied. Measurements of weakly buffered lakes show a parallel decline in lake water pH with the lowest values measured, 5.1, 4.6 and 4.4, respectively in the same regions. Correspondingly, the percentage of lakes sampled with little or no acid neutralizing capacity (ANC) was found to increase from 0 to 4 and 13%, respectively. The geographic patterns in ionic composition of airborne acids and bases, and the resultant surface water concentrations are compared. The acid forming capacity (AFC) from airborne inputs is calculated using mass balance and in-lake processes. Stoichiometric acid-base reactions are used to balance the observed chemical differences between airborne inputs and surface water composition considering nitrification, denitrification, other oxidation-reduction reactions, and the evaporation concentration process. Microbial activity in surface water can result in a net decrease in ionic strength from the conversion of most of the ammonium and nitrate to neutral compounds and biomass, but only a partial reduction of about 20% of the sulfate inputs to weakly buffered lakes. The resulting AFC of airborne inputs are calculated to range from 30 to 60, 50 to 90, and 80 to 130 μeq H+L-l, respectively, in northeastern Minnesota-Ontario, northcentral Wisconsin and northern Michigan-Ontario. The differences in AFC of airborne inputs from west to east, and differences in in-lake processes explain the observed acidity of weakly buffered lakes across the region.  相似文献   

The effect on model identifiability of allowing different relocation rates for live and dead animals in the combined analysis of telemetry and recapture data     

Marlina?D.?NasutionEmail author  Cavell?Brownie  Kenneth?H.?Pollock  Roger?A.?Powell 《Journal of Agricultural, Biological & Environmental Statistics》2004,9(1):27-41

Models are described for the joint analysis of live-trapping and radio telemetry data from a study on black bears (Ursus americanus) in which all animals received ear tags and a subset also received radio tags. Concerns about bias in survival estimates led to investigation of identifiability and estimator precision for a series of models that allowed differenttelemetry relocation rates for living and dead animals, in addition to emigration and seasonal variation in survival. Identifiability was determined by showing that the expected information matrix was nonsingular. Models with fidelity constant across time, and with the same degree of time specificity for survival rates and relocation rates for dead animals, were determined to be nonidentifiable. More general models, with a greater degree of time specificity for survival rates, were near-singular, and estimators under these near-singular models had poor precision. Analysis of data from the study on black bears illustrated that estimates of survival have poor precision when relocation rates are estimated separately for live and dead animals. It is recommended that the effort expended to relocate both living and dead animals be consistently high in each telemetry survey, so that relocation rates will be high and constant across time and mortality status.  相似文献