The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma          下载免费PDF全文

Alexandra Keller  Bettina Wingelhofer  Barbara Peter  Karin Bauer  Daniela Berger  Susanne Gamperl  Martin Reifinger  Sabine Cerny‐Reiterer  Richard Moriggl  Michael Willmann  Peter Valent  Emir Hadzijusufovic 《Veterinary and comparative oncology》2018,16(1):55-68

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Comparison of the molecular effects of the mycotoxins beta-zearalenol and deoxynivalenol in porcine endometrial cells--a review     

Wollenhaupt K  Tomek W  Tiemann U 《Acta veterinaria Hungarica》2007,55(1):123-133

The mycotoxins beta-zearalenol (beta-ZOL) and deoxynivalenol (DON) produce toxic effects that result in diseases in humans and animals. The molecular mechanisms that control the mycotoxin-mediated effects are far from being completely understood. Various results show that these mycotoxins could inhibit cell proliferation. In the present short communication, the influence of beta-ZOL and DON on the abundance and phosphorylation state of kinases that are included in regulation of the initiation of mRNA translation (which is correlated with cell proliferation) was compared in porcine endometrial cells (PEC). Our results indicate that these mycotoxins modulate the expression and phosphorylation of these factors in a different manner. Whereas beta-ZOL mainly had an impact on the biological activity of the extracellular signal-regulated protein kinases 1 and 2 (ERK1/2), protein kinase B (Akt), eukaryotic initiation factor 4E (eIF4E) and its repressor 4E binding protein 1 (4E-BP1), DON reduced the abundance of p38 MAPk, Akt and specific 4E-BP1 bands. In summary, these results indicate that beta-ZOL influences molecular events that are included in the initiation of mRNA translation in the porcine endometrium but DON does not alter such processes clearly.  相似文献   

Canine inflammatory bowel disease     

Walker D  Garden O  Allenspach K 《The Veterinary record》2007,160(16):560

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Using the Idexx SediVue Dx to predict the need for urine bacteriologic culture in cats     

Elisabeth Neubert  Karin Weber 《Journal of veterinary diagnostic investigation》2021,33(6):1202

We analyzed urine samples from 191 cats for bacteriuria with an automated urine sediment analyzer (Idexx SediVue Dx), combined with image review by an observer, and compared to bacteriologic culture results. Sixty-nine samples were unambiguously assigned to be free of bacteria by the instrument and the observer, and no bacterial growth was detected. Twenty-seven samples were unambiguously assigned to have bacteriuria; 24 of these 27 samples were culture-positive. For these samples, bacteriuria was predicted with a sensitivity of 100% and a specificity of 96%. A clear assignment was not possible for 95 samples, 81 of which were culture-negative. Specificity dropped to 45% when all samples were considered. Using the automated leukocyte count to predict bacteriuria, sensitivity was 82% and specificity was 75%. Automated sediment analysis is faster and less observer-dependent than sediment analysis under a microscope, but accurate detection of bacteriuria remains difficult in a large proportion of samples. Bacteriuria was significantly associated with leukocyte count; the leukocyte count was >5/high power field in 82% of culture-positive samples.  相似文献   

Marine protected areas and ocean basin management     

K. David Hyrenbach  Karin A. Forney  Paul K. Dayton 《水产资源保护:海洋与淡水生态系统》2000,10(6):437-458

1. All reserve designs must be guided by an understanding of natural history and habitat variability. 2. Differences in scale and predictability set aside highly dynamic pelagic systems from terrestrial and nearshore ecosystems, where wildlife reserves were first implemented. Yet, as in static systems, many pelagic species use predictable habitats to breed and forage. Marine protected areas (MPAs) could be designed to protect these foraging and breeding aggregations. 3. Understanding the physical mechanisms that influence the formation and persistence of these aggregations is essential in order to define and implement pelagic protected areas. We classify pelagic habitats according to their dynamics and predictability into three categories: static, persistent and ephemeral features. 4. While traditional designs are effective in static habitats, many important pelagic habitats are neither fixed nor predictable. Thus, pelagic protected areas will require dynamic boundaries and extensive buffers. 5. In addition, the protection of far‐ranging pelagic vertebrates will require dynamic MPAs defined by the extent and location of large‐scale oceanographic features. 6. Recent technological advances and our ability to implement large‐scale conservation actions will facilitate the implementation of pelagic protected areas. 7. The establishment of pelagic MPAs should include enforcement, research and monitoring programmes to evaluate design effectiveness. 8. Ultimately, society will need a holistic management scheme for entire ocean basins. Such overarching management will rely on many innovative tools, including the judicious use of pelagic MPAs. Copyright © 2000 John Wiley & Sons, Ltd.  相似文献   

Binding of imidacloprid,thiamethoxam and N‐desmethylthiamethoxam to nicotinic receptors of Myzus persicae: pharmacological profiling using neonicotinoids,natural agonists and antagonists          下载免费PDF全文

Hartmut Kayser  Katrin Lehmann  Marilyne Gomes  Wolfgang Schleicher  Karin Dotzauer  Margarethe Moron  Peter Maienfisch 《Pest management science》2016,72(11):2166-2175

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Ecosystem services in Swedish forests     

Karin Hansen  Mikael Malmaeus 《Scandinavian Journal of Forest Research》2016,31(6):626-640

We identify, describe qualitatively, quantify biophysically and, if possible, monetarily valuate the most important ecosystem services in Swedish forests. Existing Swedish and Nordic research and statistics within this area are reviewed and used to develop a first framework for the valuation of ecosystem services in Swedish forests. We base our analysis on the CICES framework and the Cascade-model. Despite the rather long occurrence and use of the concept of ecosystem services, we do not yet have enough information on the status and economic value of services in Swedish forests. The value of the forest ecosystem services is at best an indication of the different multifunctional objectives that should be met in the management of the Swedish forests. The five most central ecosystem services in Swedish forests according to annual flow are timber and pulpwood, bioenergy, game, climate regulation and recreation and training, each estimated to have a monetary value of several billion SEK. The different ecosystem services in multipurpose forests interact with each other and may lead to conflicts between use and conservation. We identified a number of trade-offs and synergies between services focusing on the five above ecosystem services.  相似文献   

Diagnostic PCR assays to unravel food web interactions in cereal crops with focus on biological control of aphids     

Karin Staudacher  Mattias Jonsson  Michael Traugott 《Journal of pest science》2016,89(1):281-293

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Cold tolerance during juvenile development in sorghum: a comparative analysis by genomewide association and linkage mapping          下载免费PDF全文

Karin Fiedler  Wubishet A. Bekele  Claudia Matschegewski  Rod Snowdon  Silke Wieckhorst  Arndt Zacharias  Ralf Uptmoor 《Plant Breeding》2016,135(5):598-606

Improved cold tolerance during the juvenile phase is a major breeding goal to develop new sorghum cultivars suitable as an alternative energy crop in temperate regions. The objectives of this study were to identify marker‐trait associations for cold tolerance in a sorghum diversity panel fingerprinted with 2620 single nucleotide polymorphism (SNP) markers and to detect quantitative trait loci (QTL) in two F_2:3 populations. Traits of interest were dry matter growth rate (DMGR), leaf appearance rate (LAR), chlorophyll content (SPAD) and chlorophyll fluorescence (F_v′/F_m′ and Ф_PSII) in relation to temperature. The association panel comprised 194 genotypes, while the F_2:3 populations consisted of 80 and 92 genotypes. All populations were tested under controlled conditions in a minimum of four temperature regimes ranging from 9.4°C to 20.8°C. QTL were identified for means across environments and regression parameters describing temperature effects. Several marker‐trait associations for mean (m) DMGR, base temperature (T_b) of SPAD and Ф_PSII and temperature effect on LAR were validated by QTL detected in population 1 or 2. Promising QTL regions were found on chromosomes SBI‐01, SBI‐02, SBI‐03, SBI‐04, SBI‐06 and SBI‐09, among them genomic regions where candidate genes involved in the C‐repeat binding pathway or encoding cold‐shock proteins are located.  相似文献   

The Potato Tuber Disease Occurrence as Affected by Conventional and Organic Farming Systems     

Berit Tein  Karin Kauer  Eve Runno-Paurson  Viacheslav Eremeev  Anne Luik  Are Selge  Evelin Loit 《American Journal of Potato Research》2015,92(6):662-672

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