Retrospective analysis of the clinical utility of ambulatory electrocardiographic (Holter) recordings in syncopal dogs: 44 cases (1991-1995)     

Miller RH  Lehmkuhl LB  Bonagura JD  Beall MJ 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1999,13(2):111-122

The objective of this study was to evaluate retrospectively the clinical utility of ambulatory (Holter) electrocardiographic monitoring in syncopal dogs and to compare the Holter recording with the clinic electrocardiogram (ECG) in these animals. Fifty Holter reports and 44 medical records from 44 dogs were evaluated. A syncopcal episode occurred during monitoring in 24% of the recordings. No obvious relationship was found between the frequency of syncope occurring before Holter recording and the likelihood of a dog having an episode during recording. Holter recordings were helpful in establishing a diagnosis 42% of the time, but no relationship was detected between the frequency of episodes occurring before Holter recording and the likelihood of a diagnostically useful Holter. An arrhythmia was ruled out as the cause of syncope in 12% of the recordings and was implicated as the cause of syncope in 30% of recordings. Of these, 20% were ventricular tachyarrhythmias and 10% were bradyarrhythmias including pacemaker failure. Ambulatory electrocardiographic recordings led to a therapeutic change in 38% of cases. A comparison of the Holter recordings and clinic ECGs documented the expected increased sensitivity for Holter detection of arrhythmias. The average clinic ECG heart rate consistently exceeded the average Holter heart rate with a mean difference between the average heart rates recorded by the two techniques of 31 bpm (range -8-87 bpm).  相似文献   

Effects of long-term administration of enalapril on clinical indicators of renal function in dogs with compensated mitral regurgitation     

Atkins CE  Brown WA  Coats JR  Crawford MA  DeFrancesco TC  Edwards J  Fox PR  Keene BW  Lehmkuhl L  Luethy M  Meurs K  Petrie JP  Pipers F  Rosenthal S  Sidley JA  Straus J 《Journal of the American Veterinary Medical Association》2002,221(5):654-658

OBJECTIVE: To determine the effect of long-term administration of enalapril on renal function in dogs with severe, compensated mitral regurgitation. DESIGN: Randomized controlled trial. ANIMALS: 139 dogs with mitral regurgitation but without overt signs of heart failure. PROCEDURE: Dogs were randomly assigned to be treated with enalapril (0.5 mg/kg [0.23 mg/lb], PO, q 24 h) or placebo, and serum creatinine and urea nitrogen concentrations were measured at regular intervals for up to 26 months. RESULTS: Adequate information on renal function was obtained from 132 dogs; follow-up time ranged from 0.5 to 26 months (median, 12 months). Mean serum creatinine and urea nitrogen concentrations were not significantly different between dogs receiving enalapril and dogs receiving the placebo at any time, nor were concentrations significantly different from baseline concentrations. Proportions of dogs that developed azotemia or that had a +/- 35% increase in serum creatinine or urea nitrogen concentration were also not significantly different between groups. Conclusions: And Clinical Relevance: Results suggest that administration of enalapril for up to 2 years did not have any demonstrable adverse effects on renal function in dogs with severe, compensated mitral regurgitation.  相似文献   

Chronic proliferative rhinitis associated with Salmonella arizonae in sheep.     

J T Meehan  K A Brogden  C Courtney  R C Cutlip  H D Lehmkuhl 《Veterinary pathology》1992,29(6):556-559

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Characterization and identification of a bovine respiratory syncytial virus isolated from young calves.     

H D Lehmkuhl  P M Gough  D E Reed 《American journal of veterinary research》1979,40(1):124-126

Two identical viruses designated 371 and 375 were recovered from nasal secretions of 2 of 7 calves in a beef cow-calf herd in which calves (45 to 105 days of age) had signs of acute respiratory tract disease. The cytopathic, morphologic and physico-chemical characteristics of the isolates were those of bovine respiratory syncytial virus. Although a humoral antibody response to bovine respiratory syncytial virus was not observed, it was concluded that this virus probably had a part in the respiratory tract disease in these calves.  相似文献   

Experimentally induced respiratory syncytial viral infection in lambs   总被引：3，自引：0，他引：3  

H D Lehmkuhl  R C Cutlip 《American journal of veterinary research》1979,40(4):512-544

Signs of clinical illness, lesions, and seroconversion were observed in lambs experimentally inoculated with a respiratory syncytial virus of bovine origin. Signs of clinical illness were mild and consisted of fever and hyperpnea. Multifocal areas of interstitial pneumonia were seen in lambs necropsied during the period of clinical response. All lambs seroconverted to viral antigen, and the virus was isolated from two of the lambs.  相似文献   

Seroprevalence of ovine progressive pneumonia virus in various domestic and wild animal species, and species susceptibility to the virus     

R C Cutlip  H D Lehmkuhl  K A Brogden  M J Schmerr 《American journal of veterinary research》1991,52(2):189-191

Ovine progressive pneumonia is caused by a lentivirus of known infectivity only for sheep and goats. Virus susceptibility of 11 other species of animals was examined. Species included cattle, chickens, deer, dogs, goats, hamsters, horses, mice, pigs, rabbits, and rats. Of these species, only goats and rabbits could be experimentally infected with the virus. The infection in rabbits was acute, and virus did not persist or induce antibody production as it does in sheep and goats. Sera obtained from several people working in close contact with the virus and from several wild species, with unknown exposure history, were tested for antibodies to viral antigens. All results were negative. Knowledge of the host range of this virus is important for scientific studies and for virus eradication programs.  相似文献   

Intrauterine transmission of ovine progressive pneumonia virus   总被引：2，自引：0，他引：2  

R C Cutlip  H D Lehmkuhl  T A Jackson 《American journal of veterinary research》1981,42(10):1795-1797

Ovine fetuses, newborn lambs, and ovine colostrum were examined for ovine progressive pneumonia virus. The lambs and colostrum were also examined for specific antibody. Virus was isolated from 1 fetus, from 2 newborn lambs, and from most samples of colostrum. The fetus was about 100 days old and was carried by a seronegative ewe in contact with seropositive sheep. Both newborn lambs were carried by seropositive ewes. One lamb was dead at birth; the other lamb was normal and had not nursed. Antibody specific for the virus was present in the colostrum of 12 of 14 seropositive ewes and in the serum of 8 of 11 lambs that had nursed seropositive ewes, but not in the serum of lambs that had not nursed.  相似文献   

Fatal pulmonary edema in white-tailed deer (Odocoileus virginianus) associated with adenovirus infection.     

S D Sorden  L W Woods  H D Lehmkuhl 《Journal of veterinary diagnostic investigation》2000,12(4):378-380

Sporadic sudden deaths in adult white-tailed deer occurred from November 1997 through August 1998 on an Iowa game farm. Three of the 4 deer necropsied had severe pulmonary edema, widespread mild lymphocytic vasculitis, and amphophilic intranuclear inclusion bodies in scattered endothelial cells in blood vessels in the lung and abdominal viscera. Immunohistochemistry with bovine adenovirus 5 antisera and transmission electron microscopy demonstrated adenoviral antigen and nucleocapsids, respectively, within endothelial cells. Adenovirus was isolated in cell culture from 1 of the affected deer. The isolate was neutralized by California black-tailed deer adenovirus antiserum. These findings indicate that adenovirus should be considered in the differential diagnosis of both black-tailed and white-tailed deer with pulmonary edema and/or hemorrhagic enteropathy.  相似文献   

An epizootic of adenovirus-induced hemorrhagic disease in captive black-tailed deer (Odocoileus hemionus).     

W M Boyce  L W Woods  M K Keel  N J MacLachlan  C O Porter  H D Lehmkuhl 《Journal of zoo and wildlife medicine》2000,31(3):370-373

Ten fawns and four adult black-tailed deer (Odocoileus hemionus) in a captive herd died as a result of adenovirus-induced hemorrhagic disease. Acute, systemic infections were characterized by hemorrhagic enteropathy, pulmonary edema, and occasional ulceration of the upper alimentary tract. Localized infections were limited to the upper alimentary tract and included stomatitis, pharyngitis, mandibular osteomyelitis, and rumenitis. In deer with acute, systemic infections, a diagnosis was made by histopathology and immunohistochemistry. The serum neutralization test was useful for confirming a diagnosis in animals with prolonged, localized infections. Deer originating from herds with a history of adenovirus infection should not be transferred to other captive herds or released into free-ranging populations because they may serve as carriers of adenovirus.  相似文献   

B‐mode ultrasonography biometry of the Amazon Parrot (Amazona aestiva) eye     

Ricardo C. Lehmkuhl  Mariana F. Almeida  Maria J. Mamprim  Luiz C. Vulcano 《Veterinary ophthalmology》2010,13(Z1):26-28

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