Chemotherapy followed by half-body radiation therapy for canine lymphoma     

Williams LE  Johnson JL  Hauck ML  Ruslander DM  Price GS  Thrall DE 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2004,18(5):703-709

A protocol of induction chemotherapy followed by half-body radiation therapy for treatment of lymphoma was used in 94 dogs. Seventy-three (78%) dogs achieved complete remission. Substage (P = .011) and phenotype (P = .015) were identified as predictors of complete remission rate. Of these, 52 dogs received half-body irradiation. Cranial and caudal halves received a total dose of 8.0 Gy, given in 2 fractions of 4.0 Gy on consecutive days with cobalt-60 photons and a 3-week interval between halves. Median 1st remission for these dogs was 311 days. Anemia was identified as the only predictor for length of 1st remission (P = .024). Toxicoses after half-body irradiation generally were mild and infrequent and included myelosuppression and gastrointestinal signs. Thirty-one dogs relapsed and 20 resumed treatment with induction followed by maintenance chemotherapy. Seventeen (85%) dogs achieved a 2nd complete remission. Median overall remission for all 52 dogs was 486 days. Results of this study suggest that half-body radiation therapy after induction chemotherapy is well tolerated and might increase remission duration compared with conventional protocols that use chemotherapy alone, but this increase might not be long enough to be clinically relevant or to justify application of the method described herein.  相似文献   

Immunohistochemical localization of endothelial and inducible nitric oxide synthase within neurons of cattle with rabies   总被引：1，自引：0，他引：1  

Shin T  Weinstock D  Castro MD  Hamir AN  Wampler T  Walter M  Kim HY  Acland H 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2004,66(5):539-541

The expression of constitutive endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) in the brains of cattle with natural rabies was studied. Increased expression of eNOS was detected in neurons of the brain stem and Purkinje cells of cerebellum. By contrast, iNOS was diffusely localized in the cytoplasm of affected neurons, and some inflammatory cells were positive. eNOS and rabies antigen were co-localized in inclusion bodies (Negri bodies) in neurons. The specific localization of eNOS, but not iNOS, in the Negri bodies suggests that eNOS is involved in the formation of rabies virus inclusion bodies.  相似文献   

Nutrition-related claims on children's cereals: what do they mean to parents and do they influence willingness to buy?     

Harris JL  Thompson JM  Schwartz MB  Brownell KD 《Public health nutrition》2011,14(12):2207-2212

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Laparoscopic-assisted colopexy and sterilization in male dogs: short-term results and physiologic consequences     

Mathon DH  Palierne S  Meynaud-Collard P  Layssol-Lamour C  Dulaurent-Ferrieres A  Colson A  Lacroix M  Bousquet-Melou A  Delverdier M  Autefage A 《Veterinary surgery : VS》2011,40(4):500-508

Objective: To describe laparoscopic‐assisted colopexy and sterilization, and evaluate outcome and effects in healthy male dogs. Study Design: Experimental study. Animals: Male Beagle dogs (n=7). Methods: A laparoscopic‐assisted, extracorporeally sutured colopexy, and sterilization by ligation and section of the testicular vessels and ductus deferens were evaluated 11 weeks after surgery. Ex vivo tensile tests were performed on the colopexy sites and loss of testicular function was assessed by monitoring serum testosterone, and by ultrasonographic and histologic examinations of the testes. Systemic inflammation and potential iatrogenic colonic functional disorders were investigated by monitoring serum C‐reactive protein (CRP) in the perioperative period and from a sulfapyridine (SP) kinetic profile obtained before and 10 weeks after surgery. Results: No intraoperative complications were recorded and clinical outcome was considered fair in all dogs. A mean tensile force of 42 N was required to disrupt colopexies. No relevant postoperative increase in CRP concentrations or changes in SP kinetics were observed. Testicular function was lost. Conclusions: Laparoscopic‐assisted colopexy achieved adhesion of the colon to the abdominal wall and testicular endocrine function and spermatogenesis were eliminated by laparoscopic castration.  相似文献   

Tritrichomonas foetus damages bovine oocytes in vitro     

Benchimol M  da Silva Fontes R  Burla Dias AJ 《Veterinary research》2007,38(3):399-408

Tritrichomonas foetus is an extracellular parasite of the urogenital tract in cattle. It causes infertility and abortion, but there is no documented information on the susceptibility of bovine oocytes to the parasite, except by one article that claimed no effects of T. foetus on oocytes or embryos. The aim of the present study was to study the effects provoked by T. foetus when in interaction with bovine oocytes. Oocytes were obtained from cow ovaries and divided into two groups: (1) one group contained cumulus cells, whereas (2) a second group was denuded from these cells. Light microscopy, video microscopy and scanning electron microscopy (SEM) revealed that exposure of oocytes to T. foetus caused rapid adhesion of the trichomonads to cumulus cells and to the zona pellucida (ZP). Motile parasites were observed for 12 h. The ZP was completely damaged, and the parasites were able to infiltrate beneath the ZP and reached the oocytes directly when the oocytes were denuded of the cumulus cells. Both the oocytes and the cumulus cells exhibited morphological characteristics compatible with apoptosis after interaction with T. foetus, such as chromatin condensation, the presence of several cytoplasmic vacuoles, with intact cellular membranes and organelles. The results from this study demonstrate that when a large number of T. foetus interacts with oocytes in vitro damage and apoptosis are provoked in the cow's reproductive cells. The behavior of this parasite as one of the causes of cattle infertility is discussed.  相似文献   

Firocoxib efficacy preventing urate-induced synovitis, pain, and inflammation in dogs     

Drag M  Kunkle BN  Romano D  Hanson PD 《Veterinary therapeutics : research in applied veterinary medicine》2007,8(1):41-50

This positive-control study evaluated the efficacy of firocoxib versus carprofen, deracoxib, and meloxicam for the prevention of pain and inflammation in a urate crystal synovitis model of lameness. Lameness scoring and force plate gait analysis were used to assess efficacy. The resulting lameness scores and force plate ground reaction forces after urate crystal injection were not significantly different among the groups. Relative to each group's baseline (nonlame) score, only the firocoxib group was not significantly lame, based on lameness score, at the model's peak effect.  相似文献   

ALUMINUM TOXICITY IN CORN PLANTS CULTIVATED WITH LOW AND HIGH IONIC STRENGTH NUTRIENT SOLUTIONS     

Elisa Sandra Tanaka de Farias  José Carlos Pintro  Maria Anita Gonçalves da Silva  Antonio Saraiva Muniz  Marlene Estevão Marchetti  Antonio Nolla 《Journal of plant nutrition》2013,36(3):465-475

The objective of the present study was to evaluate the phytotoxic effect of aluminum (Al) in corn plants in nutrient solution under high ionic strength (0.0094 uM) and low ionic strength (0.00001 uM). Regarding the low ionic strengths, nutrient solution was added daily until the end of the experimental period. The findings showed that the pH of the nutrient solution reduced with the increase in Al concentration, under both high and low ionic strengths solutions. Electrical conductivity of the nutrient solution increased with Al concentrations only in the solution with low ionic strength, demonstrating that the plant was more sensible to the element toxicity, thus reducing its growth and absorption of nutrients. The production of the total dry mass of corn was affected by the increase of Al concentration in the solution only under low ionic strengths, which reinforces the greater activity and absorption of the element under such condition.  相似文献   

An in vitro study to determine the minimal bactericidal concentration of sodium hypochlorite (bleach) required to inhibit meticillin‐resistant Staphylococcus pseudintermedius strains isolated from canine skin     

Marlene Pariser  Sharon Gard  Dunbar Gram  Lynn Schmeitzel 《Veterinary dermatology》2013,24(6):632-e157

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Necrotic grapevine material from the current season is a source of Botrytis cinerea inoculum     

Marlene V. Jaspers  Alison M. Seyb  Michael C. T. Trought  Rengasamy Balasubramaniam 《European journal of plant pathology / European Foundation for Plant Pathology》2016,144(4):811-820

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Characterization of deficiency symptoms and mineral nutrient content in Acmella oleracea cultivated under macronutrient and boron omissions     

Diego Alves Peçanha  MartaSimone Mendonça Freitas  Marlene Evangelista Vieira  Thaísa Capato Lima  Ygor de Souza Gonçalves 《Journal of plant nutrition》2019,42(8):879-890

Acmella oleracea occurs in the Amazon forest and is widely consumed in regional cuisine and folk medicine. Many studies concerning its active principles are available, but few studies have been carried out regarding mineral nutrition. The aim of this study was to characterize deficiencies symptoms and nutritional content in Acmella oleracea. The experimental design applied was a randomized block with four replications. After blooming, following treatments were applied: complete solution, absence of Nitrogen, Phosphorus, Potassium, Calcium, Magnesium, Sulfur, and Boron. After harvesting, growth and nutrient content of inflorescences, new leaves, old leaves, and stems were assessed. The absence of aforementioned nutrients allowed for characterization of visual deficiency symptoms. The first observed symptom was absence of Nitrogen. The accumulation of macronutrients in inflorescences followed the order N?>?K?>?Ca?>?P?>?S?>?Mg, in new leaves, N?>?K?>?Ca?>?S>Mg?>?P, in old leaves, K?>?N?>?Ca?>?Mg?>?S?>?P, and in stems K?>?N?>?Ca?>?Mg?>?P?>?S. The greatest growth restrictions were observed in nitrogen and calcium absence treatments.  相似文献