Acute thallium toxicosis in a dog.     

C B Waters  E C Hawkins  D W Knapp 《Journal of the American Veterinary Medical Association》1992,201(6):883-885

A Doberman Pinscher was evaluated for acute onset of gastroenteritis, characterized by anorexia, hematemesis, and hematochezia. The dog had ingested mole bait containing thallium 2 days prior to admission. Thallium toxicosis was confirmed by detection of thallium in the urine, using colorimetric analysis. The dog responded well to administration of antibiotics, fluids administered IV, warm-water enemas, and oral administration of activated charcoal slurries.  相似文献   

Anthelmintic efficacy of clioxanide against experimentally induced Fasciola hepatica infections in calves     

P J Presidente  S E Knapp  M W Schlegel  J N Armstrong 《American journal of veterinary research》1972,33(8):1593-1601

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Efficacy of rafoxanide against natural Fasciola hepatica infections in cattle     

S E Knapp  P J Presidente 《American journal of veterinary research》1971,32(8):1289-1291

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A comparison of extradural and intravenous methadone on intraoperative isoflurane and postoperative analgesia requirements in dogs     

Leibetseder EN  Mosing M  Jones RS 《Veterinary anaesthesia and analgesia》2006,33(2):128-136

Objective To compare the effects of intravenous (IV) and extradural (ED) methadone on end‐tidal isoflurane concentration (Fe ′ISO) and postoperative analgesic requirements in dogs undergoing femoro‐tibial joint surgery. Study Design Randomized, blinded, clinical study. Animals Twenty‐four healthy client‐owned dogs undergoing surgical repair of ruptured cruciate ligaments. Methods Dogs were randomly assigned to two groups of 12 animals and received either ED or IV methadone (0.3 mg kg^?1 diluted with saline to 0.2 mL kg^?1). Pre‐anaesthetic medication was IV acepromazine (0.05 mg kg^?1). Anaesthesia was induced with propofol and maintained initially with an Fe ′ISO of 1.0% delivered in oxygen. Methadone was injected with the dogs in sternal recumbency; the observer was unaware of the administration route. At 10 minutes (stimulation 1) and 20 minutes (stimulation 2) after methadone administration pelvic limb reflexes were tested by digit‐clamping. The time at skin incision (stimulation 3), joint‐capsule incision (stimulation 4), tibial tuberosity drilling (stimulation 5), fabellar suturing (stimulation 6) and extracapsular tightening (stimulation 7) were noted. Changes in heart rate (HR) and respiratory rate and arterial blood pressure associated with surgery were recorded along with the corresponding Fe ′ISO. After 20 minutes of anaesthesia, Fe ′ISO was decreased to the minimum required to maintain stable anaesthesia. Immediately after tracheal extubation, 1, 2, 3 and 6 hours postoperatively and on the morning after surgery, the degree of pain present was assessed using a numerical rating scale. The HR, respiratory rates and blood pressure were also recorded at these times. Serum cortisol and blood glucose concentrations were measured before pre‐anaesthetic medication and at each postoperative pain scoring interval except at 1 and 2 hours. Ketoprofen (2 mg kg^?1), carprofen (4 mg kg^?1) or meloxicam (0.2 mg kg^?1) were given by subcutaneous injection whenever pain scoring indicated moderate discomfort was present. Results Controlled ventilation was required in six dogs which stopped breathing after IV methadone. The median Fe ′ISO at stimulus 5 was 1.0% in the IV and 0.83% in the ED group. At stimulus 6, Fe ′ISO was 1.0% in the IV and 0.8% in the ED group; the difference was statistically significant (p ≤ 0.05). There was no significant difference in the duration of postoperative analgesia associated with administration route. Conclusions Extradural methadone significantly reduces the isoflurane requirement compared with IV methadone during femoro‐tibial joint surgery in dogs. Clinical relevance Extradural methadone provides safe and effective pain relief in dogs undergoing cruciate ligament repair.  相似文献   

Individual cell migration serves as the driving force for optic vesicle evagination     

Rembold M  Loosli F  Adams RJ  Wittbrodt J 《Science (New York, N.Y.)》2006,313(5790):1130-1134

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Ultrasound-guided endoscopic diode laser ablation in dogs with transitional cell carcinoma     

Knapp DW 《Journal of the American Veterinary Medical Association》2012,240(7):802; author reply 802-802; author reply 803

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Hygienic acceptance of wood in food industry     

Sebastjan Filip  Rok Fink  Martina Oder  Mojca Jev?nik 《Wood Science and Technology》2012,46(4):657-665

Food is physically manipulated by other materials during production processes, and therefore, food quality and safety are vital in processes where foods are in contact with various materials. Wooden frames were used for centuries for dried egg pasta trays; however, with the development of different materials, wood was slowly abandoned and replaced by plastic. Nevertheless, there are some hygienic considerations concerning plastic frames in the dried egg pasta making industry. In this study, plastic and wooden trays were analysed by swabbing (n?=?210) and evaluated in regard to total number of aerobic counts (TAC), Enterobacteriaceae, Escherichia coli, moulds, yeasts and Staphylococcus aureus using dry medium plates. The aims of the research were to (1) evaluate the total number of microorganisms on wood and plastic material used for pasta trays and (2) make a hygienic evaluation of analysed materials for application in the pasta industry. The research was aimed to answer the question, ‘Does the tray material and/or location of the swab sample influence the colony forming unit (CFU)/20?cm²?’ Results showed a statistical difference in CFU/20?cm² for all bacterial determinations, except for E. coli which was not detected in swabs taken from wooden or plastic trays. This hygiene evaluation study supported the conclusion that the use of wood is appropriate in the food industry from a hygienic and technological point of view.  相似文献   

Pathogenicity of Eimeria praecox alone or associated with Eimeria acervulina in experimentally infected broiler chickens     

Répérant JM  Dardi M  Pagès M  Thomas-Hénaff M 《Veterinary parasitology》2012,187(1-2):333-336

Eimeria praecox and Eimeria acervulina are two species of coccidia parasites infecting chickens, which develop in the duodenum. The purpose of this study was to evaluate the pathogenicity of E. praecox and to study interactions of this coccidium with E. acervulina. The results showed that the pathogenicity of E. praecox was related to the infective dose, and that its impact on individual weight and weight gain was significant from the lowest administered dose: 5000 oocysts per bird. No morbidity was observed, even with the highest infective dose, but faecal consistency alteration was higher with increasing infective doses. No consistent lesion was observed. When E. praecox was associated with E. acervulina with a low infective dose, performance deterioration seemed to be an additional effect of the two species. However, in the case of heavy infections, signs worsened along with duration of negative impact on growth, compared to a mono-infection.  相似文献   

Prolonged neuromuscular blockade in a horse following concomitant use of vecuronium and atracurium     

Gurney M  Mosing M 《Veterinary anaesthesia and analgesia》2012,39(1):119-120

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Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer     

Leach TN  Childress MO  Greene SN  Mohamed AS  Moore GE  Schrempp DR  Lahrman SR  Knapp DW 《Veterinary and comparative oncology》2012,10(2):102-112

The purpose of this study was to assess the toxicoses and antitumor activity of metronomic chlorambucil at a dosage of 4 mg m(-2) daily in dogs with naturally occurring cancer. Thirty-six dogs were enrolled in the study. The protocol was well tolerated with no grade 3 or 4 toxicoses noted. Complete remission was achieved, and lasted over 35 weeks in three dogs (mast cell tumour, soft tissue sarcoma and thyroid carcinoma). Partial remission was noted in 1 dog with histiocytic sarcoma (39 weeks duration) for an overall remission rate of 11% (4 of 36). Stable disease was noted in 17 dogs (47%) with various other cancers. The median progression-free interval was 61 days, and the median survival time was 153 days. Chlorambucil given in a metronomic protocol showed antitumor activity in dogs with a variety of naturally occurring cancers.  相似文献