Bilateral Sertoli and Interstitial Cell Tumours in Abdominal Testes of a Goat with Polled Intersex Syndrome (PIS)     

IF Canisso  LL Coffee  K Ortved  SL Fubini  LV Monteagudo  DH Schlafer  RO Gilbert 《Reproduction in domestic animals》2014,49(6):e64-e69

An 8‐year‐old, mixed breed, polled goat was presented for evaluation of male‐like behaviour. Clinical findings included clitoromegaly, a heavily muscled neck, pronounced beard, and erect dorsal guard hairs, which are phenotypic characteristics commonly observed in intersex animals. Transrectal ultrasonography revealed the presence of two abdominal masses caudolateral to the uterine horns. Serum concentration of estradiol was elevated. Genetic evaluation was compatible with polled intersex syndrome defined by an XX karyotype without a Y chromosome or SRY gene. Based on gross and histologic evaluation, the abdominal masses were determined to be intra‐abdominal testes, each of which was effaced by Sertoli cell and interstitial (Leydig) cell tumours. The Sertoli cell tumours (SCTs) represented two unique histologic patterns. Regardless of pattern, neoplastic Sertoli cells were consistently lipid laden and positive for vimentin. Interstitial cell tumours (ICTs) were negative for vimentin. Clinical and histopathologic findings suggest that prolonged exposure to steroids secreted by neoplastic Sertoli cells contributed to virilization. In addition, results from immunohistochemistry indicated that vimentin may be a valuable immunodiagnostic tool for differentiation between interstitial and Sertoli cell tumours in goats.  相似文献   

Dermatoses caused by infestations of immature Ixodes spp. on dogs and cats in Sydney, Australia   总被引：1，自引：1，他引：0  

CG Baxter  LJ Vogelnest  SL Doggett 《Australian veterinary journal》2009,87(5):182-187

Infestations of larval and nymphal Ixodes spp. were identified in 16 dogs and 16 cats from several small animal clinics in Sydney. Cases occurred in late summer or autumn, peaking in February, and were seasonally recurrent in some individuals. Clinical signs of infestation included a papular dermatitis and irritation or pruritus that ranged from severe to mild or absent. The distribution of tick attachment tended to be cranial and ventral, with the face, legs, axillae and ventrum the most commonly affected sites. The estimated number of ticks in each infestation varied from less than 10 to more than 100. Basic morphological examination of ticks collected from affected animals was performed by attending veterinarians using light microscopy, and larvae and nymphs belonging to the Ixodes genus were identified. Ticks collected from 17 animals and submitted to the Department of Medical Entomology, Westmead Hospital were putatively identified as I. trichosuri (57%) and I. holocyclus (25%) larvae. Histopathological samples of attachment sites collected from three dogs and one cat were characterised by ticks attached in well-demarcated invaginations of the skin ('tick craters') associated with variable epidermal and/or dermal necrosis, focal eosinophilic intraspinous pustules, mild to marked eosinophilic and neutrophilic, superficial to deep, dermal perivascular to interstitial inflammation, and moderate to marked superficial dermal oedema and red cell extravasation. A range of topical acaricidal preparations, including fipronil and synthetic pyrethroids, were used for treatment.  相似文献   

Cyanide toxicosis in goats after ingestion of California Holly (Heteromeles arbutifolia).     

John H Tegzes  Birgit Puschner  Larry A Melton 《Journal of veterinary diagnostic investigation》2003,15(5):478-480

Cyanogenic glycosides are found in many native and naturalized plants throughout North America. The glycosides themselves are not toxic, but they yield hydrogen cyanide (hydrocyanic or prussic acid) when they are hydrolyzed by beta-glycosidases, either as a result of injury to the plant cells or by microbial action in the rumen. Hydrogen cyanide is readily absorbed from the gastrointestinal tract. Cyanide ion binds with iron in cytochrome oxidase, interfering with cellular respiration. The clinical effects are peracute, often resulting in death less than 1 hour after ingestion. This study describes a case that resulted in significant morbidity and mortality in a herd of goats after exposure to California holly (Heteromeles arbutifolia).  相似文献   

Cervical diskospondylitis in two horses     

CM COLBOURNE  SL RAIDAL  JV YOVICH  JMcC HOWELL  JL RICHARDSON 《Australian veterinary journal》1997,75(7):477-479

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Influence of cultivar,cooking, and storage on cell-wall polysaccharide composition of winter squash (Cucurbita maxima)     

Ratnayake RM  Melton LD  Hurst PL 《Journal of agricultural and food chemistry》2003,51(7):1904-1913

Changes in the cell-wall polysaccharides (CWP) of the edible tissues of four winter squash cultivars during storage and after cooking were investigated. A procedure for isolating cell walls of tissues containing high levels of starch was used. The starch-free CWP were sequentially fractionated using CDTA, dilute Na(2)CO(3), and 4 M KOH. Cellulose made up 40-42% of the total CWP for three cultivars (Delica, CF 2, and CF 4) at harvest but was 35% in the softer Red Warren. The pectic polysaccharides of Delica, CF 2, and CF 4 cell walls are more branched than those from Red Warren squash. The higher proportion of uronic acid in the pectic polysaccharides of Red Warren squash correlates with its lower firmness. Cooking resulted in an increase in the water-soluble pectins and a decrease in the pectins associated with cellulose. The total CWP content of the squash cultivars remained unchanged for up to 2 months of storage and then markedly decreased between 2 and 3 months of storage. The galactose content of Delica and Red Warren cell walls remained relatively constant from harvest to 2 months of storage and then decreased markedly during 2-3 months of storage.  相似文献   

Assessment of Ram and Boar Spermatozoa during Cell-sorting by Flow Cytometry   总被引：1，自引：0，他引：1  

SL Catt  JK O'Brien  WMC Maxwell  G Evans 《Reproduction in domestic animals》1997,32(5):251-258

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Neural tube defects in four Shetland sheepdog puppies: clinical characterisation and computed tomography investigation     

ZM Thomas  JM Podadera  SL Donahoe  TSY Foo  L Weerakoon  H Mazrier 《Australian veterinary journal》2020,98(7):312-318

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Partially Molten Middle Crust Beneath Southern Tibet: Synthesis of Project INDEPTH Results   总被引：23，自引：0，他引：23  

KD Nelson  W Zhao  LD Brown  J Kuo  J Che  X Liu  SL Klemperer  Y Makovsky  R Meissner  J Mechie  R Kind  F Wenzel  J Ni  J Nabelek  C Leshou  H Tan  W Wei  AG Jones  J Booker  M Unsworth  WSF Kidd  M Hauck  D Alsdorf  A Ross  M Cogan  C Wu  E Sandvol  M Edwards 《Science (New York, N.Y.)》1996,274(5293):1684-1688

INDEPTH geophysical and geological observations imply that a partially molten midcrustal layer exists beneath southern Tibet. This partially molten layer has been produced by crustal thickening and behaves as a fluid on the time scale of Himalayan deformation. It is confined on the south by the structurally imbricated Indian crust underlying the Tethyan and High Himalaya and is underlain, apparently, by a stiff Indian mantle lid. The results suggest that during Neogene time the underthrusting Indian crust has acted as a plunger, displacing the molten middle crust to the north while at the same time contributing to this layer by melting and ductile flow. Viewed broadly, the Neogene evolution of the Himalaya is essentially a record of the southward extrusion of the partially molten middle crust underlying southern Tibet.  相似文献   

Effects of cooking on the cell walls (dietary fiber) of 'Scarlet Warren' winter squash ( Cucurbita maxima ) studied by polysaccharide linkage analysis and solid-state (13)C NMR     

Ratnayake RM  Sims IM  Newman RH  Melton LD 《Journal of agricultural and food chemistry》2011,59(13):7186-7193

Cell wall polysaccharides of 'Scarlet Warren' winter squash ( Cucurbita maxima ) were investigated before and after thermal processing. Linkage analysis of polysaccharides was done by gas chromatography coupled to mass spectrometry (GC-MS). The linkage analysis showed the cell wall polysaccharide compositions of raw and cooked squash were similar. The total pectic polysaccharides (galacturonan, rhamnogalacturonan, arabinan, and arabinogalactan) contents of the cell walls of both raw and cooked squash were 39 mol %. The amounts of pectic polysaccharides and xyloglucan in the cell walls of squash showed little alteration on heating. The cellulose content of the raw and cooked cell walls was relatively high at 47 mol %, whereas the xyloglucan content was low at 4 mol %. Solid-state (13)C nuclear magnetic resonance (NMR) spectroscopy techniques were used to examine the molecular motion of the polysaccharides in the cell walls. The mobility of highly flexible galactan depends on the water content of the sample, but no difference was seen between raw and cooked samples. Likewise, the mobility of semimobile pectic polysaccharides was apparently unaltered by cooking. No change was detected in the rigid cellulose microfibrils on cooking.  相似文献   

Platelet-derived growth factor A chain is maternally encoded in Xenopus embryos   总被引：21，自引：0，他引：21  

M Mercola  D A Melton  C D Stiles 《Science (New York, N.Y.)》1988,241(4870):1223-1225

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