Bilateral Dorsal Subluxation of the Proximal Interphalangeal Joint of the Hind Limb in a Mare: Case Report     

Dietrich Pizzigatti  Carlos Alberto Hussni  Celso Antonio Rodrigues  Marcos Jun Watanabe  Juliana de Moura Alonso  Luiz Carlos Vulcano  Luis Emiliano Cisneros Álvarez 《Journal of Equine Veterinary Science》2013

Subluxation of the proximal interphalangeal joint is a rare and little studied condition in horses. We describe the case of a 12-year-old mare with bilateral dorsal subluxation of the proximal interphalangeal joint of the hind feet. Tenectomy of the medial digital flexor was performed in both limbs, and the patient showed signs of recovery within 14 days. Goniometry of the proximal interphalangeal joints 10 months after surgery showed diminution of 5° for the proximal interphalangeal axis of the left hind limb. However, no change was found for the joint angle of the right limb. Even so, the patient's gait and radiographic results were normal, and clinical abnormalities such as joint clicking and swelling were no longer observed.  相似文献   

Clinical and genetic aspects of X-linked ectodermal dysplasia in the dog -- a review including three new spontaneous cases     

Moura E  Cirio SM 《Veterinary dermatology》2004,15(5):269-277

This review presents the clinical, dermato-histopathological and genetic features of canine X-linked ectodermal dysplasia in previously reported cases and in three new spontaneous cases. The condition is compared with anhidrotic ectodermal dysplasia in humans and, based on current genetic concepts, we suggest that the two conditions are caused by the same gene and, consequently, represent a single pathological entity that affects both humans and dogs.  相似文献   

巴西家禽基因组研究进展及应用前景     

E.C.Jorge  A.Figueira  M.C.Ledur  A.S.A.M.T.Moura  L.L.Coutinho  程金花 《中国家禽》2008,30(24)

1 家禽遗传学和基因组学的背景 20世纪以来由于引入先进的统计遗传学程序可以更好地估计动物性状的遗传力和育种值,经典的育种方法得到了很大的提高。多年的选育使得鸡的性状有了很大提高,同时在产量和适应性方面也有所增强。除了选育带来的成功外,对蛋肉生产进行选育获得的遗传进展理论上在接下来的20年里达到其生物极限。  相似文献   

First proteomic analysis of diestrus and anestrus canine oocytes at the germinal vesicle reveals candidate proteins involved in oocyte meiotic competence     

Leda Maria Costa Pereira  Paulo Ricardo de Oliveira Bersano  Arlindo de Alencar Moura  Maria Denise Lopes 《Reproduction in domestic animals》2019,54(12):1532-1542

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Nuclear parameters and chromatin remodeling in epithelial cells and lymphocytes from the palpebral conjunctiva of dogs with keratoconjunctivitis sicca     

Daniela Moura dos Santos  Marcela Aldrovani  Marcella Rosa Filezio  Thais Guimares Morato Abreu  Camila Pinho Balthazar da Silveira  Nathan Rocha das Neves Cruz  Jos Luiz Laus 《Veterinary ophthalmology》2019,22(1):39-49

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Proteome of the periovulatory oviduct and uterus of goats as related to nutritional balance          下载免费PDF全文

César Carneiro Linhares Fernandes  Paula Rodriguez‐Villamil  Fábio Roger Vasconcelos  Celso Shiniti Nagano  Rafael Rossetto  Arlindo de Alencar Araripe Noronha Moura  Davide Rondina 《Reproduction in domestic animals》2018,53(5):1085-1095

This study was conducted to evaluate the effects of different feeding levels on the proteome of oviduct and uterus tissues of hormonally stimulated goats during the periovulatory period. Forty goats were separated into four different diet groups: Diet 1.0 M (n = 11), Diet 1.3 M (n = 10), Diet 1.6 M (n = 9), Diet 1.9 M (n = 10), fed with 1.0, 1.3, 1.6 and 1.9 times live weight maintenance, respectively. After four weeks of treatment, six hormonally stimulated females per treatment group were randomly selected for collection of uterine and the oviduct tissue samples. Samples were collected after animals were slaughtered in a commercial unit. Feeding goats with 1.3 to 1.9 times more nutrients than a control group directly influenced the proteome of the oviduct and uterus, altering the expression of proteins that participate in biological processes such as apoptosis, antioxidant, and immunological activities. These events are crucial for fertilization and early embryonic survival. Expression of oviduct proteins such as Tubulin Beta 2B, Transferrin and Disulphide‐isomerase A3 increased in the 1.9 M group in relation to the other feeding levels. Disulphide‐isomerase A4 showed higher expression in the 1.0 M group compared to diets with higher energetic levels. As energy intake increased in the diets, there was higher expression of Alpha‐1‐antitrypsin and downregulation of Profilin‐1 in the uterus of the goats. In conclusion, this study showed that specific proteins of the goat oviduct and uterus expressed during the periovulatory period are modified as the result of nutritional balance.  相似文献   

Bone Morphogenetic Protein‐6 (BMP‐6) Stimulates the Antrum Formation by the Regulation of its Signalling Pathway in Caprine Pre‐antral Follicles Cultured In Vitro          下载免费PDF全文

VR Araújo  GM Silva  ABG Duarte  DM Magalhães‐Padilha  AP Almeida  FO Lunardi  MKB Serafim  AAA Moura  CC Campello  APR Rodrigues  JR Figueiredo 《Reproduction in domestic animals》2016,51(1):59-68

BMP‐6 has been found to be important to ovarian cells and oocyte, as well as to uterus. Thus, this study investigated the effect of bone morphogenetic protein (BMP‐6) and recombinant follicle‐stimulating hormone (rFSH) alone or in combination on the in vitro culture (IVC) of isolated caprine secondary follicles (Experiment 1) and the mRNA levels for BMP receptors/Smad signalling pathway (BMPR1A, BMPR2, SMAD1, SMAD4, SMAD5, SMAD6, SMAD7 and SMAD8) in vivo and in vitro using BMP‐6 (Experiment 2). Secondary follicles were cultured in αMEM⁺ alone (control medium) or supplemented with BMP‐6 at 1 or 10 ng/ml and rFSH alone or the combination of both BMP‐6 concentrations and rFSH. The results from Experiment 1 showed that the antrum formation rate was higher in the BMP‐6 at 1 ng/ml (p < 0.05) than in MEM. In Experiment 2, the mRNA expression for BMPR2, SMAD1, SMAD5 and SMAD6 was detected in non‐cultured control and after in vitro culture (MEM and 1 ng/ml BMP‐6); while the expression of SMAD7 and SMAD8 mRNA was only detected after IVC, SMAD4 was only detected in the BMP‐6 at 1 ng/ml treatment. In conclusion, the low BMP‐6 concentration positively influenced antrum formation and ensured normal mRNA expression for BMP receptor and Smads after IVC of caprine secondary follicles.  相似文献   

Direct and correlated responses to selection for efficiency of lean gain in mice     

Holder RB  Moura AS  Lamberson WR 《Journal of animal science》1999,77(3):575-581

Improvement in feed efficiency when selection is based on gain:feed ratio has often been accompanied by a reduction in feed intake. The following four criteria were used in mass selection for improved lean gain efficiency in mice with an objective of evaluating changes in lean gain and intake: 1) gain deviation, animals selected had the greatest gain in fat-free mass (FFM) after adjustment to a constant intake; 2) intake deviation, mice selected had the least feed intake after adjustment to a constant gain in FFM; 3) intrinsic efficiency, similar to the second criterion except that adjustment was also made for average weight maintained during the period; and 4) a positive control that used the ratio of gain in FFM: feed intake as the selection criterion. A fifth line, in which a male and a female were selected at random from each litter, served as a negative control. Experimental animals were outbred mice of the CF1 strain. Two replicates of the five lines were included in the study. Twelve males and females were pair-mated within each line-replicate combination each generation. Feed disappearance was measured from 25 to 42 d. Mice were scanned to obtain an electrical conductivity measurement for prediction of FFM. After six generations of selection, realized heritabilities for gain:feed, gain deviation, intake deviation, and intrinsic efficiency were .00 +/- .04, .04 +/- .29, .35 +/- .08, and .28 +/- .06, respectively. There were no differences among lines for gain:feed ratio. The correlated response in feed intake reduction was significant in the intake deviation and intrinsic efficiency lines (-.17 +/- .05 and -.21 +/- .04 g x d(-1) x generation(-1), respectively). The realized genetic correlations between the ratio and gain deviation, intake deviation, and intrinsic efficiency were .83 +/- .15, .01 +/- .04, and .21 +/- .12, respectively. Litter size was depressed in all selected lines.  相似文献   

Estrous cycle-dependent differences in responsiveness to prostaglandins and contractile agents in sheep (Ovis aries) cervical smooth muscle     

Pereira AF  Melo LM  Avelar SR  Moura RR  Leal-Cardoso JH  Freitas VJ 《Journal of veterinary pharmacology and therapeutics》2007,30(6):534-540

We investigated the influence of the phase of the estrous cycle on mechanical responses elicited in sheep cervix by potassium chloride (KCl), acetylcholine chloride (ACh), prostaglandin F2 alpha (PGF2 alpha) and prostaglandin E1 (PGE1). The cervix of adult ewes (n = 48) were classified according to the presence or absence of corpora lutea (luteal or follicular phase, respectively). Muscle strips of the circular and longitudinal layers were prepared in an organ bath and coupled to an isometric force transducer. Concentration-response curves were obtained noncumulatively. KCl and ACh produced concentration-dependent contractions in all preparations in both phases of the estrous cycle. However, maximum effect, EC50 and slope values of KCl and ACh were not significantly different between muscle layers, as well as between the phases of the estrous cycle. The prostanoid, PGF2 alpha, produced a significant reduction in the amplitude of spontaneous contractions for all preparations. The depressant effect of PGF2 alpha on spontaneous contractions of circular smooth muscle was significantly greater during the follicular than the luteal phase, whilst the depressant effect of PGF2 alpha on the longitudinal layer did not differ between phases of the estrous cycle. PGE1 significantly reduced the amplitude of spontaneous contractions on circular but not on longitudinal preparations. In conclusion, we have characterized with in vitro preparations of circular and longitudinal muscle layers of ewes during the follicular and luteal phases of the estrous cycle, the parameters of the K- and ACh-induced contractions on cervix and the efficacy of PGF2 alpha and PGE1 on inhibition spontaneous contractile activity.  相似文献   

VEGF system expression in different stages of estrous cycle in the corpus luteum of non-treated and superovulated water buffalo     

Papa PC  Moura CE  Artoni LP  Fátima LA  Campos DB  Marques JE  Baruselli PS  Binelli M  Pfarrer C  Leiser R 《Domestic animal endocrinology》2007,33(4):379-389

Water buffaloes are easily adaptable animals, whose raising and economical exploitation have been growing in the last three decades all over the world. Hyperstimulation of ovarian function in this species is a common technique aiming to improve reproductive performance. Superovulatory treatment affects corpus luteum (CL) function, which is highly correlated to angiogenic process. The aim of this study was therefore to assess the temporal protein and mRNA expression of VEGF and its receptors in the CL of non-treated and superovulated buffaloes. For that purpose blood samples and CL from 36 healthy (30 untreated, groups 1–5, and 6 superovulated, group 6) non-pregnant buffaloes were collected and the samples were divided into 6 groups according to the age of CL. Plasma samples were submitted to RIA to measure progesterone concentration and CL were subjected to immunohistochemistry and real time PCR for VEGF (vascular endothelial growth factor), Flt-1 (fms-like tyrosine kinase receptor 1) and KDR (kinase insert domain containing region). The VEGF system protein and mRNA expression during CL life span of untreated animals showed a specific time-dependent profile, although protein did not always reflect mRNA concentrations. VEGF expression in luteal cells was high correlated to plasma progesterone levels. Superovulated CL showed a significant increase of the VEGF-system protein and a significant decrease of mRNA expression compared to untreated animals in the same stage of the oestrous cycle. We conclude that VEGF, Flt-1 and KDR protein and mRNA expression in buffalo CL is dependent of estrous cycle stage and superovulatory treatment is able to increase the translation rate of this system.  相似文献