Assessment of the measurement of canine and feline serum fibroblast growth factor-23 concentrations by automated chemiluminescence immunoassay     

Hirosumi MIYAKAWA  Huai-Hsun HSU  Mizuki OGAWA  Yuichi MIYAGAWA  Naoyuki TAKEMURA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2022,84(2):257

This study compared canine and feline fibroblast growth factor (FGF)-23 concentration measurements between automated chemiluminescence assay (CLEIA) and enzyme-linked immunosorbent assay (ELISA). Seventy serum samples each from dogs and cats were evaluated. FGF-23 measurements by CLEIA significantly correlated with those of ELISA in both dogs and cats. The Bland–Altman test showed that FGF-23 between CLEIA and ELISA had fixed and proportional biases, respectively, in both dogs and cats. Measurements by CLEIA were lower than those of ELISA, especially in higher serum FGF-23 concentrations. This study showed that FGF-23 concentrations in dogs and cats can be evaluated by automated CLEIA. However, FGF-23 cannot be directly compared between CLEIA and ELISA.  相似文献   

Hepatocellular toxicosis associated with the alternate administration of carprofen and meloxicam in a siberian husky     

Nakagawa K  Yamagami T  Takemura N 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2005,67(10):1051-1053

A 4-year-old female Siberian Husky was diagnosed with pyogranulomatous steatitis at the site of a recurrence of left anal sac rupture (day 1). Carprofen and orbifloxacin were given for 13 days without improvement. A single dose of meloxicam was administered prior to surgical resection of the anal sac, and based on elevated liver enzyme activity, liver supportive therapy was initiated. The dog received carprofen and orbifloxacin orally on the evening of day 14. The dog became anorectic the following morning, and began vomiting. Despite supportive therapy, the dog was unresponsive to treatment and died on day 16. Postmortem examination revealed severe vacuolar change and acute necrosis of hepatocytes consistent with carprofen and meloxicam induced-toxicosis.  相似文献   

Influence of rice whole‐crop silage diet on growth performance,carcass and meat characteristics and muscle‐related gene expression in Japanese Black steers          下载免费PDF全文

Masahiro Shibata  Yasuko Hikino  Mai Imanari  Kazunori Matsumoto  Naoyuki Yamamoto 《Animal Science Journal》2016,87(7):929-937

The present study investigated the influence of a diet largely comprising rice whole‐crop silage (rWCS) on growth performance, carcass and meat characteristics, and expression of genes involved in muscle growth of Japanese Black steers. Steers were randomly separated into rWCS‐fed (rWCS ad libitum and restricted feeding of concentrate) and concentrate‐fed groups. Total digestible nutrient intake and daily gain (DG) decreased in rWCS‐fed steers in comparison with concentrate‐fed steers, whereas dressed carcass weight and final body weight did not significantly differ between the groups. Decreases in drip loss in the muscle of rWCS‐fed steers may be caused by α‐tocopherol and β‐carotene in muscle. Feeding large amounts of rWCS to steers may maintain quantitative productivity of beef steers equally to a concentrate‐based diet, and improve the qualitative productivity. Results of gene expression suggest that activation of skeletal muscle growth in rWCS‐fed steers may occur at the late fattening period owing to a decrease in myostatin and increase in myosin heavy chain gene expression. Preadipocyte factor‐1 and myostatin genes may be strongly involved in the control of lipid accumulation. This rearing system would allow beef production to switch to rWCS‐based diets from concentrate‐based diets.  相似文献   

Prevalence of Giardia intestinalis and other zoonotic intestinal parasites in private household dogs of the Hachinohe area in Aomori prefecture, Japan in 1997, 2002 and 2007     

Naoyuki Itoh  Kazutaka Kanai  Yasutomo Hori  Fumio Hoshi  Seiichi Higuchi 《Journal of veterinary science (Suw?n-si, Korea)》2009,10(4):305-308

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Leaf spot of barnyardgrass caused by Exserohilum oryzicola in Japan and the fungal influence on rice,barley, bread wheat,durum wheat,and soybean     

Tomioka  Keisuke  Asami  Hidenori  Chiba  Masahiro  Kobayashi  Hidekazu  Nagata  Kenji  Mori  Shinsuke  Yamazaki  Ryo  Kawasaki  Yohei  Yasumoto  Satoko  Masunaka  Akira  Sekiguchi  Hiroyuki  Ishikawa  Naoyuki 《Journal of General Plant Pathology》2021,87(5):281-286

Journal of General Plant Pathology - Brown lesions were found on leaves of the weed barnyardgrass in paddy fields in Hiroshima Prefecture in western Japan in June 2017. A fungus, isolated...  相似文献   

A yeast prion, Mod5, promotes acquired drug resistance and cell survival under environmental stress   总被引：1，自引：0，他引：1  

Suzuki G  Shimazu N  Tanaka M 《Science (New York, N.Y.)》2012,336(6079):355-359

Prion conversion from a soluble protein to an aggregated state may be involved in the cellular adaptation of yeast to the environment. However, it remains unclear whether and how cells actively use prion conversion to acquire a fitness advantage in response to environmental stress. We identified Mod5, a yeast transfer RNA isopentenyltransferase lacking glutamine/asparagine-rich domains, as a yeast prion protein and found that its prion conversion in yeast regulated the sterol biosynthetic pathway for acquired cellular resistance against antifungal agents. Furthermore, selective pressure by antifungal drugs on yeast facilitated the de novo appearance of Mod5 prion states for cell survival. Thus, phenotypic changes caused by active prion conversion under environmental selection may contribute to cellular adaptation in living organisms.  相似文献   

Effect of row type,flowering type and several other spike characters on resistance to Fusarium head blight in barley     

Megumi?YoshidaEmail author  Naoyuki?Kawada  Takuji?Tohnooka 《Euphytica》2005,141(3):217-227

Fusarium head blight (FHB) is a destructive disease of barley. The genetics and expression of resistance to FHB in barley is complex, and various spike characters are thought to possibly influence resistance. Tests using spray-inoculation of Fusarium graminearum at anthesis in greenhouse environments showed that two-rowed and cleistogamous varieties from Japan belong to the highest resistance group, while six-rowed and chasmogamous varieties are mostly susceptible. In order to evaluate the effect of such spike characters, including row type and flowering type, on FHB resistance, near-isogenic lines (NILs) differing in these characters were tested for their resistance. Two testing methods were used: the pot-plant and cut-spike methods, in which spikes at anthesis were spray-inoculated in greenhouse environments. The chasmogamous NILs and some six-rowed NILs were significantly more diseased than cleistogamous and two-rowed parent lines, respectively, and the difference in FHB severity was greater and more stable between cleistogamous/chasmogamous NIL pairs than between two-/six-rowed pairs. Slight or no differences were observed in glaucous/non-glaucous, normal/dense spike, normal/uzu type and normal/deficiens NIL pairs. The results indicate that the contribution of cleistogamy and/or the genetic background toward FHB resistance is more than that of row type and the other tested spike characters. Further, it should be possible to develop six-rowed varieties with FHB resistance nearly as good as that of the two-rowed varieties.  相似文献   

Multifunctional Alloys Obtained via a Dislocation-Free Plastic Deformation Mechanism     

Saito T  Furuta T  Hwang JH  Kuramoto S  Nishino K  Suzuki N  Chen R  Yamada A  Ito K  Seno Y  Nonaka T  Ikehata H  Nagasako N  Iwamoto C  Ikuhara Y  Sakuma T 《Science (New York, N.Y.)》2003,300(5618):464-467

We describe a group of alloys that exhibit "super" properties, such as ultralow elastic modulus, ultrahigh strength, super elasticity, and super plasticity, at room temperature and that show Elinvar and Invar behavior. These "super" properties are attributable to a dislocation-free plastic deformation mechanism. In cold-worked alloys, this mechanism forms elastic strain fields of hierarchical structure that range in size from the nanometer scale to several tens of micrometers. The resultant elastic strain energy leads to a number of enhanced material properties.  相似文献   

Evaluation of the Autonomic Nervous System in a Canine Model of Chronic Embolic Pulmonary Hypertension     

Ogawa  Mizuki  Ishizaka  Mio  Akabane  Ryota  Sakatani  Atsushi  Nagakawa  Masayoshi  Miyakawa  Hirosumi  Miyagawa  Yuichi  Takemura  Naoyuki 《Veterinary research communications》2020,44(2):73-81

Veterinary Research Communications - Sildenafil improves autonomic dysfunction caused by pulmonary hypertension (PH) in humans, but its effect is unknown in dogs with PH. This prospective study...  相似文献   

Development of correction formulas for canine and feline urine specific gravity measured using a Japanese refractometer     

Miyagawa Y  Tominaga Y  Toda N  Takemura N 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2011,73(5):679-681

One of the most important functions of the kidney is to concentrate urine through the reabsorption of water. Urine specific gravity (USG) is used in routine tests of urine concentration and can be estimated using a refractometer. However, as the scale of Japanese refractometer is based on experimental data from healthy Japanese people, and human USG obtained by Japanese refractometers show higher values than that by refractometer produced in Europe or the U.S.A. The purpose of this study was to establish correction formulas for the USG of dogs and cats measured using Japanese refractometers. In this study, we found that Japanese refractometers overestimated USG in both dogs and cats. This study shows that the correlation formulas described in this study are useful for the accurate evaluation of USG.  相似文献