Aurasperone A Inhibits SARS CoV-2 In Vitro: An Integrated In Vitro and In Silico Study     

Mai H. ElNaggar  Ghada M. Abdelwahab  Omnia Kutkat  Mohamed GabAllah  Mohamed A. Ali  Mohamed E. A. El-Metwally  Ahmed M. Sayed  Usama Ramadan Abdelmohsen  Ashraf T. Khalil 《Marine drugs》2022,20(3)

Several natural products recovered from a marine-derived Aspergillus niger were tested for their inhibitory activity against SARS CoV-2 in vitro. Aurasperone A (3) was found to inhibit SARS CoV-2 efficiently (IC₅₀ = 12.25 µM) with comparable activity with the positive control remdesivir (IC₅₀ = 10.11 µM). Aurasperone A exerted minimal cytotoxicity on Vero E6 cells (CC₅₀ = 32.36 mM, SI = 2641.5) and it was found to be much safer than remdesivir (CC₅₀ = 415.22 µM, SI = 41.07). To putatively highlight its molecular target, aurasperone A was subjected to molecular docking against several key-viral protein targets followed by a series of molecular dynamics-based in silico experiments that suggested M^pro to be its primary viral protein target. More potent anti-SARS CoV-2 M^pro inhibitors can be developed according to our findings presented in the present investigation.  相似文献   

Morphological Characteristics of the Canine and Feline Stomach Mucosa     

P. Zahariev  E. Sapundzhiev  D. Pupaki  P. Rashev  A. Palov  T. Todorov 《Anatomia, histologia, embryologia》2010,39(6):563-568

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Neural network prediction of performance parameters of an inclined plate seed metering device and its reverse mapping for the determination of optimum design and operational parameters   总被引：2，自引：0，他引：2  

M. Anantachar  T. Guruswamy 《Computers and Electronics in Agriculture》2010,72(2):87-98

Seed planting equipment with inclined plate seed metering devices is the most commonly used equipment for planting of peanut crop in India. For obtaining the high yield, it is very essential to drop the peanut seeds in rows maintaining accurate seed rate and seed spacing with minimum damage to seeds during metering. This mainly depends on forward speed of the planting equipment, rotary speed of the metering plate and area of cells on the plate. The relationship between these factors and the performance parameters viz., seed rate, seed spacing and percent seed damage can be established using regression analysis. But they may not be very accurate and may pose difficulty in the determination of inputs for a set of desired outputs (reverse mapping). Hence, an attempt has been made in this paper to develop the feed forward artificial neural network (ANN) models for the prediction of the performance parameters of an inclined plate seed metering device. The data were generated in the laboratory by conducting experiments on a sticky belt test stand provided with a seed metering device and an opto-electronic seed counter. The generated data was used to develop both statistical and neural network models. The performance of the developed models was compared among themselves for 4 randomly generated test cases. The results show that the ANN model predicted the performance parameters of the seed metering device better than the statistical models. In order to determine the optimum forward speed of the planting equipment, peripheral speed of the metering plate and the area of cells on the plate to obtain the recommended seed rate of 33.33 seeds/m², seed spacing of 100 mm and percent seed damage of 0.2% with 100% fill of the cells, a novel technique of reverse mapping using ANN model was followed. It was observed that the optimum forward speed of the planting equipment and optimum area of cells on the metering plate had good correlation with size of seed. Linear regression equations were developed to predict the optimum forward speed of the planting equipment and optimum area of cells on the metering plate using the size of seeds as independent parameter. The peripheral speed of the metering plate of 0.237 m/s was found to be optimum for the size of seeds in the range of 95.42-123.01 mm². However, the results need to be verified by conducting planting operation under actual field conditions.  相似文献   

Movement patterns of Brook Trout in a restored coastal stream system in southern Massachusetts          下载免费PDF全文

Erin L. Snook  Benjamin H. Letcher  Todd L. Dubreuil  Joseph Zydlewski  Matthew J. O'Donnell  Andrew R. Whiteley  Stephen T. Hurley  Andy J. Danylchuk 《Ecology of Freshwater Fish》2016,25(3):360-375

Coastal Brook Trout (Salvelinus fontinalis) populations are found from northern Canada to New England. The extent of anadromy generally decreases with latitude, but the ecology and movements of more southern populations are poorly understood. We conducted a 33‐month acoustic telemetry study of Brook Trout in Red Brook, MA, and adjacent Buttermilk Bay (marine system) using 16 fixed acoustic receivers and surgically implanting acoustic transmitters in 84 individuals. Tagged Brook Trout used the stream, estuary (50% of individuals) and bay (10% of individuals). Movements into full sea water were brief when occurring. GAMM models revealed that transitions between habitat areas occurred most often in spring and fall. Environmental data suggest that use of the saline environment is limited by summer temperatures in the bay. Movements may also be related to moon phase. Compared to more northern coastal populations of Brook Trout, the Red Brook population appears to be less anadromous overall, yet the estuarine segment of the system may have considerable ecological importance as a food resource.  相似文献   

Recruitment of sympatric vendace (Coregonus albula) and whitefish (C. lavaretus) is affected by different environmental factors          下载免费PDF全文

Arne N. Linløkken  Odd T. Sandlund 《Ecology of Freshwater Fish》2016,25(4):652-663

Vendace and whitefish in Lake Osensjøen (boreal south‐east Norway) were studied by means of gillnet test fishing (1976–2013) and hydro acoustic acquisition (1986–2011). Vendace increased in number between 1998 and 2009 while growth and size at maturity decreased. The relative density of whitefish decreased in the pelagic habitat, whereas growth and size remained the same. Both species exhibited varying year‐class strength. Whereas strong year‐classes of both species became less frequent after 1980 than before this, this seemed to change after 2000, especially for vendace. Generalised additive models suggested a strong positive relationship between July/August mean air temperature and year‐class strength of both vendace and whitefish. Whitefish recruitment was also negatively affected by the new regulation regime implemented since 1981, and positively correlated with water level after hatching and by late ice off. The reason for the diverging impacts of environmental factors on the two species may be that vendace spawn in deeper waters that whitefish do. The results indicate that increasing summer temperatures benefit recruitment of both species, whereas low water level and early ice off will harm whitefish recruitment. Both trends are caused by climate warming. It may be speculated that increased density of the specialised plankton feeding vendace may affect the algal community through increased predation on herbivorous zooplankton and potentially affect the trophic state of the lake.  相似文献   

Regression analysis of plasticity and phenotypic stability of hybrid spring soft wheat populations with respect to gluten quality     

V. M. Bebyakin  T. A. Rozanova  L. N. Zlobina 《Russian Agricultural Sciences》2013,39(5-6):396-398

The plasticity and stability of hybrids selected from three heavy-eared populations according to the gluten deformation index GDI-1 are shown. The possibility of testing closely related genotypes by criteria based on ecological regression is examined. Hybrid forms valuable in adaptability that can be used in breeding are found.  相似文献   

Leaf chlorophyll content as a possible diagnostic mean for the evaluation of plant nitrogen uptake from the soil     

T. M. Shadchina  V. V. Dmitrieva 《Journal of plant nutrition》2013,36(7):1427-1437

The influence of temperature, irradiance, and soil humidity on the nitrogen (N) concentration in some organs, chlorophyll in the leaves, N uptake and accumulation of dry matter in plants of winter wheat was investigated. In the plants grown under equal initial N supplement but in contrasting conditions of the evironment, the correlation between concentration of total N and chlorophyll in the leaves was absent. No interrelationship was found between concentration of total N in the leaves and accumulation of N and dry matter in the whole plants. There is a close correlation between chlorophyll in the leaves, accumulation of total N, and dry matter of the whole plant. It was concluded that chlorophyll is a more stable informative parameter for the estimation of the N uptake from the soil under different growth conditions than leaf N concentration.  相似文献   

Erratum to: Haemopoiesis in the head kidney of tilapia, Oreochromis niloticus (Teleostei: Cichlidae): a morphological (optical and ultrastructural) study     

El-Saydah H. Abdel-Aziz  Suzan B. S. Abdu  T. El-Sayed Ali  Huda F. Fouad 《Fish physiology and biochemistry》2012,38(6):1857-1857

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The Sustainability of Quinoa Production in Southern Bolivia: from Misrepresentations to Questionable Solutions. Comments on Jacobsen (2011, J. Agron. Crop Sci. 197: 390–399)     

T. Winkel  H. D. Bertero  P. Bommel  J. Bourliaud  M. Chevarría Lazo  G. Cortes  P. Gasselin  S. Geerts  R. Joffre  F. Léger  B. Martinez Avisa  S. Rambal  G. Rivière  M. Tichit  J. F. Tourrand  A. Vassas Toral  J. J. Vacher  M. Vieira Pak 《Journal of Agronomy and Crop Science》2012,198(4):314-319

Reviewing the situation of quinoa production in southern Bolivia, Jacobsen (2011, J. Agron. Crop Sci. 197: 390) argues that the booming export market has a negative effect on the environment and on the home consumption of quinoa, thereby leading to an environmental disaster in the region. In view of the scarcity of scientific knowledge on the rapid social and environmental dynamics in the region, we consider that Jacobsen’s review misrepresents the situation of quinoa production in southern Bolivia. Specifically, we argue that (i) the data presented by Jacobsen (2011, J. Agron. Crop Sci. 197: 390) do not support any drop in quinoa crop yield supposed to reflect soil degradation and (ii) his demonstration regarding home consumption of quinoa is ill‐founded from both a nutritional and a cultural point of view. We suggest that the diffusion of the arguments exposed by Jacobsen (2011, J. Agron. Crop Sci. 197: 390), because of their flaws, might have strong negative impacts on those concerned with sustainable food production and fair‐trade with developing countries. We conclude that, rather than reinforced agro‐technical controls on local farmers, the rising competition in the international quinoa market requires a shift towards an ethical economy and ethical research cooperation with quinoa producers.  相似文献   

Effects of a plastic cover on soil moisture change in a Mediterranean climatic regime     

J. L. Díaz‐Hernández  T. Salmerón 《Soil Use and Management》2012,28(4):596-605

Water deficit is a serious problem for most agricultural crops, especially in arid–semiarid regions, and limits sustainable development. Production can be improved by reducing evapotranspiration and loss of infiltrated water by the use of a plastic cover. We monitored soil moisture fortnightly over 1 yr using a neutron probe near four trees in an olive grove (Olea europaea, var. Arbequina), two of which had a plastic cover buried in the topsoil around them. These trees were monitored using three neutron probe access tubes per tree to compare the behaviour of soil moisture over time with two other identically instrumented and nearby trees with no cover. Analysis was based on the resultant moisture profiles. The plastic cover retained moisture and increased soil water residence time. During the dry season, the amount of water retained in the plots was at most 15–20% greater in the mid‐season and at least 5–6% greater at the end of season than in the central part of the plots near the trunk. The plastic cover was effective to ca. 50 cm with maximum water content near the soil surface. During the wet season, the cover did not affect soil water. Soil moisture was greater near the tree trunk as a result of stemflow and throughfall.  相似文献