Effect of different environmental temperatures and atmospheric humidity degrees on some physiological parameters of the Goettinger miniature pig in various growth phases. I. Shoats     

S Georgiev  A Schoen  R Georgieva 《Berliner und Münchener tier?rztliche Wochenschrift》1972,85(9):171-173

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Hyperthermia in pigs at different stages of development. 3. Changes in the osmolarity of plasma, urine and saliva     

S Georgiev  M Steinhardt  L Lyhs 《Archiv fuer experimentelle veterinaermedizin》1971,25(6):975-983

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Arlenelepis harpiprioni gen. et sp. n. (Cestoda: Dilepididae) from Harpiprion caerulescens (Vieillot) (Aves: Threskiornithidae) in Paraguay     

Georgiev BB  Vaucher C 《Folia parasitologica》2004,51(4):327-332

Arlenelepis harpiprioni gen. et sp. n. (Cyclophyllidea, Dilepididae) is described from the plumbeous ibis Harpiprion caerulescens (Vieillot) (Ciconiiformes, Threskiomithidae) in Province Concepción, Paraguay. This cestode is characterised by a very small body (not exceeding 5 mm in length) consisting of about 30 proglottides, musculo-glandular rostellar apparatus, rostellar hooks arranged in two regular rows, few testes (7-10 in number) situated mostly in a post-ovarian group but one testis pre-ovarian, a large oval cirrus sac reaching antiporal osmoregulatory canals, massive cirrus armed with needle-shaped and thorn-shaped spines, long convoluted vagina, and longitudinally elongate sacciform horseshoe-shaped uterus with deep lobes of the medial uterine wall. The new genus is unique among the family Dilepididae in possessing a rhynchus armed with conical spines.  相似文献   

First record of metacestodes of Mesocestoides sp. in the common starling (Sturnus vulgaris) in Europe, with an 18S rDNA characterisation of the isolate     

Literák I  Olson PD  Georgiev BB  Spakulová M 《Folia parasitologica》2004,51(1):45-49

Metacestodes of Mesocestoides sp. were recorded from Sturnus vulgaris (Passeriformes: Stumidae) in the Czech Republic in April 2002. They were found in a cutaneous cyst and in the thoracic region of the body cavity of the bird. This is the first record of metacestodes of Mesocestoides sp. in this host species in Europe as well as the first finding of the formation of a cutaneous cyst provoked by this parasite. Additional specimens from Apodemus agrarius (Mammalia: Rodentia) from Bulgaria and Lacerta agilis (Reptilia: Squamata) from the Czech Republic were compared with that from S. vulgaris. Sequence data from the V4 variable region (18S rDNA) were used to compare genetic variability among these and previously characterized isolates of Mesocestoides spp. A number of distinct clades were recognized, with metacestodes from L. agilis showing the highest degree of relative divergence.  相似文献   

New and little-known lepidopteran (Lepidoptera) phytophages on the poplars (Populus spp.) in Bulgaria     

G. Georgiev  S. Beshkov 《Journal of pest science》2000,73(1):1-4

Investigations were carried out during the period 1997-1999 on lepidopteran entomofauna deleterious to poplars (Populus spp.) in Bulgaria. The phytophages were collected in larval and pupal stage and were reared under laboratory con-ditions to the adult stage. In two regions of Bulgaria, Sofia and Montana, 18 new and little-known phytophages in seven families were established on the trees in Populus genus: Limenitis populi (L.) (Nymphalidae); Anacampsis populefia (Cl.), Gelechia turpella (Den. & Schiff.) (Gelechiidae); Synanthedon melliniformis (Lasp.) (Sesiidae); Euproctis similis (Fuessl.) (Lymantriidae); Drymonia velitaris (Hufn.), Notodonta tritophus (Den. & Schiff.) (Notodontidae); Amphipyra pyramidea (L.), Catocala nupta (L.), Cosmia trapezina (L.), Enargia paleacea (Esp.), Eupsilia transversa (Hufn.), Ipomorpha subtusa (Den. & Schiff.), Parastichtis ypsilon (Den. & Schiff.), Scoliopteryx libatrix (L.) (Noctuidae); Gastropacha quercifolia (L.), Phyllodesma tremulifolia (Hb.) and Poecilocampa populi (L.) (Lasiocampidae). G. turpella and S. melliniformis are new records for Bulgaria and D. velitaris was found for the first time in Northern Bulgaria. Thirteen species (L. populi, E. similis, D. velltaris, N. tritophus, A. pyramidea, C. nupta, C. trapezina, E. transversa, I. subtusa, P. ypsilon, G. quercifolia, P. tremulifolia and P. populi) were established for the first time in Bulgaria to have a trophic relationship with poplars. G. turpella and L subtusa were occurred in the highest population densities – up to 1.6 larvae/m and up to 1.1 larvae/m respectively. The remaining species occurred in low population densities in the studied habitats and were not considered to be pests on the poplars.  相似文献   

Induction of Abortion with Aglepristone in Cats on Day 45 and 46 After Mating     

P Georgiev  H Bostedt  S Goericke‐Pesch  M Dimitrov  P Petkov  K Stojanthev  V Tsoneva  A Wehrend 《Reproduction in domestic animals》2010,45(5):e161-e167

The aim of this study was to test for the efficacy and safety of the use of aglepristone for pregnancy termination on day 45 in cats. Six healthy cats were treated with 10 mg/kg aglepristone sc on day 45 and 46 after mating; six other cats served as untreated controls. The effect of treatment was monitored by general examination, vaginal cytology, ultrasonography and blood sampling for haematology and progesterone determination. Besides, interoestrus interval and next pregnancy including litter size were recorded. The efficacy of treatment was approximately 67% (4/6) with abortion occurring 4–7 days after the first injection and a sanguineous discharge and erythrocytes in vaginal smears for at least 6 days afterwards. The two treated cats that did not abort gave birth to two kittens on day 67 and had a stillbirth of a single kitten on day 71, respectively. As expected enlargement of the mammary glands and lactation were observed in all treated cats. No other treatment‐induced side effects were observed. Progesterone levels at abortion were high (30–140 nmol/l), but were decreased on day 55. Aglepristone treatment did not affect fertility in following cycles. Finally, it can be concluded that late‐term pregnancy termination with aglepristone is possible but due to a success rate of 67% an ultrasonographical examination 7 days after treatment is an inherent necessity to control the effect of treatment.  相似文献   

Recombinant Strain A/HK/Otar/6:2/2010 (H3N8) for Development of a Live Intranasal Equine Influenza Vaccine     

Olga V. Chervyakova  PhD  Vitaliy M. Strochkov  Kulyaisan T. Sultankulova  Nurlan T. Sandybayev  Abylay R. Sansyzbay  Nikolay E. Gorev  Maria V. Sergeeva  Marina V. PotapchukLudmila M. Tsybalova  DMSc  Oleg I. Kiselev 《Journal of Equine Veterinary Science》2014

Recombinant cold-adapted strain A/HK/Otar/6:2/2010 (H3N8) constructed by the method of classic genetic reassortment, inherited the hemagglutinin and neuraminidase genes from the epizootic A/equine/Otar/764/2007 (Н3N8) virus and genes of nonglycosylated proteins from attenuation donor A/Hong Kong/1/68/162/35 (H3N2). The resulted virus was of cold-adapted (efficient growth at 25°C) and temperature-sensitive (restricted replication at 39°C) phenotype. Like the parental virus of subtype H3N2, the resulted reassortant was attenuated, with limited replication in lungs of mice (1.75 lgEID₅₀/mL) versus replication in turbinate (2.5 lgEID₅₀/mL). Intranasal immunization of mice with A/HK/Otar/6:2/2010 (H3N8) reassortant did not induce animal weight reduction in contrast to epizootic A/equine/Otar/764/2007 (Н3N8) virus.  相似文献   

An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models     

Burdelya LG  Krivokrysenko VI  Tallant TC  Strom E  Gleiberman AS  Gupta D  Kurnasov OV  Fort FL  Osterman AL  Didonato JA  Feinstein E  Gudkov AV 《Science (New York, N.Y.)》2008,320(5873):226-230

The toxicity of ionizing radiation is associated with massive apoptosis in radiosensitive organs. Here, we investigate whether a drug that activates a signaling mechanism used by tumor cells to suppress apoptosis can protect healthy cells from the harmful effects of radiation. We studied CBLB502, a polypeptide drug derived from Salmonella flagellin that binds to Toll-like receptor 5 (TLR5) and activates nuclear factor-kappaB signaling. A single injection of CBLB502 before lethal total-body irradiation protected mice from both gastrointestinal and hematopoietic acute radiation syndromes and resulted in improved survival. CBLB502 injected after irradiation also enhanced survival, but at lower radiation doses. It is noteworthy that the drug did not decrease tumor radiosensitivity in mouse models. CBLB502 also showed radioprotective activity in lethally irradiated rhesus monkeys. Thus, TLR5 agonists could potentially improve the therapeutic index of cancer radiotherapy and serve as biological protectants in radiation emergencies.  相似文献   

Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing     

Wu X  Zhou T  Zhu J  Zhang B  Georgiev I  Wang C  Chen X  Longo NS  Louder M  McKee K  O'Dell S  Perfetto S  Schmidt SD  Shi W  Wu L  Yang Y  Yang ZY  Yang Z  Zhang Z  Bonsignori M  Crump JA  Kapiga SH  Sam NE  Haynes BF  Simek M  Burton DR  Koff WC  Doria-Rose NA  Connors M;NISC Comparative Sequencing Program  Mullikin JC  Nabel GJ  Roederer M  Shapiro L  Kwong PD  Mascola JR 《Science (New York, N.Y.)》2011,333(6049):1593-1602

Antibody VRC01 is a human immunoglobulin that neutralizes about 90% of HIV-1 isolates. To understand how such broadly neutralizing antibodies develop, we used x-ray crystallography and 454 pyrosequencing to characterize additional VRC01-like antibodies from HIV-1-infected individuals. Crystal structures revealed a convergent mode of binding for diverse antibodies to the same CD4-binding-site epitope. A functional genomics analysis of expressed heavy and light chains revealed common pathways of antibody-heavy chain maturation, confined to the IGHV1-2*02 lineage, involving dozens of somatic changes, and capable of pairing with different light chains. Broadly neutralizing HIV-1 immunity associated with VRC01-like antibodies thus involves the evolution of antibodies to a highly affinity-matured state required to recognize an invariant viral structure, with lineages defined from thousands of sequences providing a genetic roadmap of their development.  相似文献   

Nightglow in the upper atmosphere of Mars and implications for atmospheric transport   总被引：1，自引：0，他引：1  

Bertaux JL  Leblanc F  Perrier S  Quemerais E  Korablev O  Dimarellis E  Reberac A  Forget F  Simon PC  Stern SA  Sandel B;SPICAM Team 《Science (New York, N.Y.)》2005,307(5709):566-569

We detected light emissions in the nightside martian atmosphere with the SPICAM (spectroscopy for the investigation of the characteristics of the atmosphere of Mars) ultraviolet (UV) spectrometer on board the Mars Express. The UV spectrum of this nightglow is composed of hydrogen Lyman alpha emission (121.6 nanometers) and the gamma and delta bands of nitric oxide (NO) (190 to 270 nanometers) produced when N and O atoms combine to produce the NO molecule. N and O atoms are produced by extreme UV photodissociation of O2, CO2, and N2 in the dayside upper atmosphere and transported to the night side. The NO emission is brightest in the winter south polar night because of continuous downward transport of air in this region at night during winter and because of freezing at ground level.  相似文献