Hypoglycemic effect of lupin seed γ-conglutin in experimental animals and healthy human subjects   总被引：2，自引：0，他引：2  

Bertoglio JC  Calvo MA  Hancke JL  Burgos RA  Riva A  Morazzoni P  Ponzone C  Magni C  Duranti M 《Fitoterapia》2011,82(7):933-938

A lupin seed γ-conglutin-enriched preparation was tested in a glucose overload trial with both murine models and adult healthy volunteers. The results with rats showed a dose-dependent significant decrease of blood glucose concentration, which confirmed previous findings obtained with the purified protein. Moreover, three test-product doses equivalent to 630, 315, and 157.5 mg γ-conglutin, orally administered 30 min before the carbohydrate supply, showed a relevant hypoglycemic effect in human trials. Insulin concentrations were not significantly affected. The general hematic parameters did not change at all.This is the first report on the glucose-lowering effect of lupin γ-conglutin in human subjects.  相似文献   

Nitrogen metabolism components as a tool to discriminate between organic and conventional citrus fruits     

Rapisarda P  Calabretta ML  Romano G  Intrigliolo F 《Journal of agricultural and food chemistry》2005,53(7):2664-2669

The aim of this work was to develop a method for authenticity control of organically grown orange fruits. Due to the different kinds of nitrogen fertilization of the soil in organically and conventionally managed farms, the study tried to verify the possibility to differentiate Navelina and Tarocco orange fruits obtained by these production systems through the detection of markers linked to nitrogen metabolism. In addition to the classic quality parameters, total nitrogen (N) and synephrine contents in juice and (15)N/(14)N isotope ratio (expressed as delta(15)N per thousand) in proteins of pulp and amino acids of juice were determined. The results obtained indicated that total N and synephrine contents were significantly higher in conventional fruits, whereas the delta(15)N per thousand values were higher in the organic ones. The new markers identified in this research by linear discriminant analysis of the data may constitute a useful tool to differentiate organic citrus fruits or juices from conventional ones.  相似文献   

Development and characterization of 296 new polymorphic microsatellite markers for rubber tree (Hevea brasiliensis)     

V. Le Guen  C. Gay  T. C. Xiong  L. M. Souza  M. Rodier‐Goud  M. Seguin 《Plant Breeding》2011,130(2):294-296

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EFFECT OF TEMPERATURE ON EVERSPORTING EYE COLOR IN DROSOPHILA MELANOGASTER     

Gowen JW  Gay EH 《Science (New York, N.Y.)》1933,77(1995):312

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Impact factor fever     

Cherubini P 《Science (New York, N.Y.)》2008,322(5899):191

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CHROMOSOME STRUCTURE IN THE SALIVARY GLANDS OF SCIARA     

Metz CW  Gay EH 《Science (New York, N.Y.)》1934,80(2086):595-596

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A POSSIBLE METHOD OF ENHANCING THE THERAPEUTIC ACTION OF ANTIBACTERIAL SERUMS     

Gay FP  Clark AR 《Science (New York, N.Y.)》1929,69(1797):604-605

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Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle   总被引：1，自引：0，他引：1  

Molinari M  Calanca V  Galli C  Lucca P  Paganetti P 《Science (New York, N.Y.)》2003,299(5611):1397-1400

The mechanisms that determine how folding attempts are interrupted to target folding-incompetent proteins for endoplasmic reticulum-associated degradation (ERAD) are poorly defined. Here the alpha-mannosidase I-like protein EDEM was shown to extract misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. EDEM overexpression resulted in faster release of folding-incompetent proteins from the calnexin cycle and earlier onset of degradation, whereas EDEM down-regulation prolonged folding attempts and delayed ERAD. Up-regulation of EDEM during ER stress may promote cell recovery by clearing the calnexin cycle and by accelerating ERAD of terminally misfolded polypeptides.  相似文献   

Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning     

Aiuti A  Slavin S  Aker M  Ficara F  Deola S  Mortellaro A  Morecki S  Andolfi G  Tabucchi A  Carlucci F  Marinello E  Cattaneo F  Vai S  Servida P  Miniero R  Roncarolo MG  Bordignon C 《Science (New York, N.Y.)》2002,296(5577):2410-2413

Hematopoietic stem cell (HSC) gene therapy for adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID) has shown limited clinical efficacy because of the small proportion of engrafted genetically corrected HSCs. We describe an improved protocol for gene transfer into HSCs associated with nonmyeloablative conditioning. This protocol was used in two patients for whom enzyme replacement therapy was not available, which allowed the effect of gene therapy alone to be evaluated. Sustained engraftment of engineered HSCs with differentiation into multiple lineages resulted in increased lymphocyte counts, improved immune functions (including antigen-specific responses), and lower toxic metabolites. Both patients are currently at home and clinically well, with normal growth and development. These results indicate the safety and efficacy of HSC gene therapy combined with nonmyeloablative conditioning for the treatment of SCID.  相似文献   

Unique chromatin remodeling and transcriptional regulation in spermatogenesis   总被引：1，自引：0，他引：1  

Sassone-Corsi P 《Science (New York, N.Y.)》2002,296(5576):2176-2178

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