RADIOGRAPHIC CHARACTERIZATION OF PRIMARY LUNG TUMORS IN 74 DOGS     

Laura E. Barrett  Rachel E. Pollard  Allison Zwingenberger  Alexandra Zierenberg‐Ripoll  Katherine A. Skorupski 《Veterinary radiology & ultrasound》2014,55(5):480-487

Primary pulmonary neoplasia is well recognized in dogs and prognosis depends upon the tumor type. The purpose of this retrospective study was to characterize the radiographic appearance of different primary lung tumors with the goal of establishing imaging criteria to separate the different types. Three‐view thoracic radiographs of 74 dogs with histologically confirmed pulmonary anaplastic carcinoma (n = 2), adenocarcinoma (n = 31), bronchioalveolar carcinoma (n = 19), histiocytic sarcoma (n = 21), and squamous cell carcinoma (n = 1) were evaluated. Radiographs were assessed for tumor volume, affected lobe, location within lobe, overall pulmonary pattern, presence of cavitation, mineralization, air bronchograms, lymphadenomegaly, and pleural fluid. Histiocytic sarcomas were significantly larger than other tumor types (271 cm³; P = 0.009) and most likely to be found in the left cranial (38%; 8/21) and right middle (43%; 9/21) lung lobes, whereas adenocarcinomas were most likely to be found in the left caudal (29%; 9/31) lung lobe. Fifty‐seven percent (12/21) of histiocytic sarcomas had an internal air bronchogram. Findings indicate that a large mass in the periphery or affecting the whole lobe of the right middle or left cranial lung lobe with an internal air bronchogram is likely to be an histiocytic sarcoma.  相似文献   

PREVALENCE OF COMPUTED TOMOGRAPHIC SUBCHONDRAL BONE LESIONS IN THE SCAPULOHUMERAL JOINT OF 32 IMMATURE DOGS WITH THORACIC LIMB LAMENESS     

Rachel Lande  Shona L. Reese  Laura C. Cuddy  Clifford R. Berry  Antonio Pozzi 《Veterinary radiology & ultrasound》2014,55(1):23-28

Osteochondrosis is a common developmental abnormality affecting the subchondral bone of immature, large breed dogs. The purpose of this retrospective study was to describe CT lesions detected in scapulohumeral joints of 32 immature dogs undergoing CT for thoracic limb lameness. Eight dogs (14 scapulohumeral joints) had arthroscopy following imaging. Thirteen dogs (19 scapulohumeral joints) were found to have CT lesions, including 10 dogs (16 scapulohumeral joints) with subchondral bone lesions and 3 dogs with enthesopathy of the supraspinatus tendon. In one dog, subchondral bone lesions appeared as large oval defects within the mid‐aspect of the glenoid cavities, bilaterally. These lesions resembled osseous cyst‐like lesions commonly identified in the horse. This is the first report of such a presentation of a subchondral bone lesion in the glenoid cavity of a dog. In all dogs, small, focal, round or linear lucent defects were visible within the cortical bone at the junction of the greater tubercle and intertubercular groove. These structures were thought to represent vascular channels. Findings from this study support the use of CT as an adjunct modality for the identification and characterization of scapulohumeral subchondral bone lesions in immature dogs with thoracic limb lameness.  相似文献   

A comparison in dogs of medetomidine,with or without MK‐467, and the combination acepromazine‐butorphanol as premedication prior to anaesthesia induced by propofol and maintained with isoflurane     

Kati Salla  Rachel C Bennett  Flavia Restitutti  Jouni Junnila  Marja Raekallio  Outi Vainio 《Veterinary anaesthesia and analgesia》2014,41(2):163-173

ObjectiveTo compare the haemodynamic effects of three premedicant regimens during propofol-induced isoflurane anaesthesia.Study designProspective, randomized cross-over study.AnimalsEight healthy purpose-bred beagles aged 4 years and weighing mean 13.6 ± SD 1.9 kg.MethodsThe dogs were instrumented whilst under isoflurane anaesthesia prior to each experiment, then allowed to recover for 60 minutes. Each dog was treated with three different premedications given intravenously (IV): medetomidine 10 μg kg^?1 (MED), medetomidine 10 μg kg^?1 with MK-467 250 μg kg^?1 (MMK), or acepromazine 0.01 mg kg^?1 with butorphanol 0.3 mg kg^?1 (AB). Anaesthesia was induced 20 minutes later with propofol and maintained with isoflurane in oxygen for 60 minutes. Heart rate (HR), cardiac output, arterial blood pressures (ABP), central venous pressure (CVP), respiratory rate, inspired oxygen fraction, rectal temperature (RT) and bispectral index (BIS) were measured and arterial and venous blood gases analyzed. Cardiac index (CI), systemic vascular resistance index (SVRI), oxygen delivery index (DO₂I), systemic oxygen consumption index (VO₂I) and oxygen extraction (EO₂) were calculated. Times to extubation, righting, sternal recumbency and walking were recorded. The differences between treatment groups were evaluated with repeated measures analysis of covariance.ResultsHR, CI, DO₂I and BIS were significantly lower with MED than with MMK. ABP, CVP, SVRI, EO₂, RT and arterial lactate were significantly higher with MED than with MMK and AB. HR and ABP were significantly higher with MMK than with AB. However, CVP, CI, SVRI, DO₂I, VO₂I, EO₂, T, BIS and blood lactate did not differ significantly between MMK and AB. The times to extubation, righting, sternal recumbency and walking were significantly shorter with MMK than with MED and AB.Conclusions and clinical relevanceMK-467 attenuates certain cardiovascular effects of medetomidine in dogs anaesthetized with isoflurane. The cardiovascular effects of MMK are very similar to those of AB.  相似文献   

Social networks in complex human and natural systems: the case of rotational grazing,weak ties,and eastern US dairy landscapes     

Kristen C. Nelson  Rachel F. Brummel  Nicholas Jordan  Steven Manson 《Agriculture and Human Values》2014,31(2):245-259

Multifunctional agricultural systems seek to expand upon production-based benefits to enhance family wellbeing and animal health, reduce inputs, and improve environmental services such as biodiversity and water quality. However, in many countries a landscape-level conversion is uneven at best and stalled at worst. This is particularly true across the eastern rural landscape in the United States. We explore the role of social networks as drivers of system transformation within dairy production in the eastern United States, specifically rotational grazing as an alternative management option. We hypothesize the importance of weak ties within farmer social networks as drivers of change. In Wisconsin, Pennsylvania, and New York, we conducted 53 interviews with confinement, low-intensity, and rotational grazing dairy producers as well as 35 interviews with associated network actors. Though confinement and grazier networks had similar proportions of strong and weak ties, confinement producers had more market-based weak ties, while graziers had more weak-ties to government agencies and other graziers in the region. These agency weak ties supported rotational graziers through information exchange and cost sharing, both crucial to farmers’ transitions from confinement-based production to grazing systems. While weak ties were integral to initial innovation, farmers did not maintain these relationships beyond their transition to grazing. Of equal importance, grazier weak-tie networks did not include environmental organizations, suggesting unrealized potential for more diverse networks based on environmental services. By understanding the drivers, we can identify barriers to expanding weak tie networks and emergent properties in order to create institutions and policies necessary for change.  相似文献   

Paramyxovirus and reovirus infections in wild-caught Mexican lizards (Xenosaurus and Abronia spp.).     

Rachel E Marschang  Shannon Donahoe  Ruth Manvell  Julio Lemos-Espinal 《Journal of zoo and wildlife medicine》2002,33(4):317-321

Virus isolation attempts were carried out on wild-caught Xenosaurus grandis, X. platyceps, and Abronia graminea from Mexico. These animals were also tested for exposure to paramyxoviruses and reoviruses. Pharyngeal and cloacal swabs were collected from 30 lizards, and blood was collected from 23 lizards. A cytopathogenic virus was isolated from the cloacal swab of one of the X. platyceps. The isolate was identified as a paramyxovirus on the basis of its sensitivity to chloroform, resistance to 5-iodo-2'-deoxyuridine, size and morphology of the viral particles, hemagglutination of chicken erythrocytes, and serologic reaction with paramyxovirus-specific antisera. Antibodies against the paramyxovirus isolated in this study were found in four animals from three species. Antibodies against a different paramyxovirus isolated from a monitor lizard were found in seven animals from three species, showing that all the species tested are susceptible to paramyxovirus infections. Antibodies to a reptilian reovirus were found in three of the X. grandis.  相似文献   

The genomic sequence of the bovine T cell receptor gamma TRG loci and localization of the TRGC5 cassette     

Conrad ML  Mawer MA  Lefranc MP  McKinnell L  Whitehead J  Davis SK  Pettman R  Koop BF 《Veterinary immunology and immunopathology》2007,115(3-4):346-356

The bovine and ovine TRG genes have previously been shown to be located in two loci, TRG1 and TRG2, in contrast to human and mouse TRG genes that are located in a single locus. The bovine TRG1 and TRG2 loci are located on chromosome 4 at 4q3.1 and 4q1.5-2.2, respectively. The complete genomic organization of the two bovine loci is described: each locus comprises three cassettes, each one includes one or several variable genes (TRGV) and one or several joining genes (TRGJ) preceding a constant (TRGC) gene. The location of the TRGC5 cassette is conclusively described in 5' of the TRG1 locus. Analysis of 17 TRGV belonging to 10 different subgroups, 8 TRGJ and 6 TRGC genes is conducted which comprises the most comprehensive list to date.  相似文献   

Keystone effects of the endangered Stephens' kangaroo rat (Dipodomys stephensi)     

Rachel E. Brock 《Biological conservation》2004,116(1):131-139

Kangaroo rats (Dipodomys) have been argued to exert keystone effects because they interact strongly with other species, and their removal results in major changes in community structure. We evaluated the nature and magnitude of such impacts by the endangered Stephens' kangaroo rat (Dipodomys stephensi), employing an exclosure experiment to determine how the removal of this species impacted relative cover by vegetation, plant species diversity, abundance of a dominant annual plant genus (Erodium), and predation of seeds from artificial trays. Fifteen months of D. stephensi removal resulted in significant increases in herb cover and Erodium abundance, and significant declines in bare ground and in seed predation. These results support the hypothesis that D. stephensi has major impacts on plant community structure and seems to function as a keystone species. It remains to be seen how the loss of this species from much of its range will influence local community composition and dynamics.  相似文献   

Characterizing stand-replacing disturbance in western Alberta grizzly bear habitat, using a satellite-derived high temporal and spatial resolution change sequence     

Rachel Gaulton  Thomas HilkerMichael A. Wulder  Nicholas C. CoopsGordon Stenhouse 《Forest Ecology and Management》2011,261(4):865-877

Timely and accurate mapping of anthropogenic and natural disturbance patterns can be used to better understand the nature of wildlife habitats, distributions and movements. One common approach to map forest disturbance is by using high spatial resolution satellite imagery, such as Landsat 5 Thematic Mapper (TM) or Landsat 7 Enhanced Thematic Mapper plus (ETM+) imagery acquired at a 30 m spatial resolution. However, the low revisit times of these sensors acts to limit the capability to accurately determine dates for a sequence of disturbance events, especially in regions where cloud contamination is a frequent occurrence. As wildlife habitat use can vary significantly seasonally, annual patterns of disturbance are often insufficient in assessing relationships between disturbance and foraging behaviour or movement patterns.The Spatial Temporal Adaptive Algorithm for mapping Reflectance Change (STAARCH) allows the generation of high-spatial (30 m) and -temporal (weekly or bi-weekly) resolution disturbance sequences using fusion of Landsat TM or ETM+ and Moderate Resolution Imaging Spectroradiometer (MODIS) imagery. The STAARCH algorithm is applied here to generate a disturbance sequence representing stand-replacing events (disturbances over 1 ha in area) for the period 2001-2008, over almost 6 million ha of grizzly bear habitat along the eastern slopes of the Rocky Mountains in Alberta. The STAARCH algorithm incorporates pairs of Landsat images to detect the spatial extent of disturbances; information from the bi-weekly MODIS composites is used in this study to assign a date of disturbance (DoD) to each detected disturbed area. Dates of estimated disturbances with areas over 5 ha are validated by comparison with a yearly Landsat-based change sequence, with producer's accuracies ranging between 15 and 85% (average overall accuracy 62%, kappa statistic of 0.54) depending on the size of the disturbance event. The spatial and temporal patterns of disturbances within the entire region and in smaller subsets, representative of the size of a grizzly bear annual home range, are then explored. Disturbance levels are shown to increase later in the growing season, with most disturbances occurring in late August and September. Individual events are generally small in area (<10 ha) except in the case of wildfires, with, on average, 0.4% of the total area disturbed each year. The application of STAARCH provides unique high temporal and spatial resolution disturbance information over an extensive area, with significant potential for improving understanding of wildlife habitat use.  相似文献   

What factors influence the stem taper of <Emphasis Type="Italic">Eucalyptus</Emphasis>: growth,environmental conditions,or genetics?     

Hugues Yvan Gomat  Philippe Deleporte  Régis Moukini  Gladys Mialounguila  Nina Ognouabi  Aubin Rachel Saya  Philippe Vigneron  Laurent Saint-Andre 《Annals of Forest Science》2011,68(1):109-120

• Introduction   

Stem taper equations have been widely used for volume estimation to varied top diameter limits or for biomass calculations. However, their main drawback is that specific calibration is often necessary for each species or clone, and accounting for genetic and environmental effects is often a challenge.  相似文献   

Antioxidant activity of A-type proanthocyanidins from Geranium niveum (Geraniaceae)     

Maldonado PD  Rivero-Cruz I  Mata R  Pedraza-Chaverrí J 《Journal of agricultural and food chemistry》2005,53(6):1996-2001

Geranium niveum S. Watson (Geraniaceae) is a medicinal herb widely used by the Tarahumara Indians of Mexico. This species is rich in proanthocyanidins and other phenolics. Previous in vitro assays have demonstrated that proanthocyanidins exhibited antiinflammatory, antiviral, antibacterial, enzyme-inhibiting, antioxidant, and radical-scavenging properties. In view of its medicinal use and chemical composition, the aim of the present study was to determine the in vitro antioxidant activity of the extracts and two proanthocyanidins (geranins A and D) from the roots of G. niveum by using seven different assay systems, namely, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide anion (O2*-), hydrogen peroxide (H2O2), hydroxyl radical (OH*), hypochlorous acid (HOCl), and singlet oxygen ((1)O2). Two known antioxidants, resveratrol and ascorbic acid, were used as positive controls. The results showed that geranins A and D and the extracts were able to scavenge ABTS, DPPH, O2*-, OH*, and HOCl. The scavenging ability of geranins A and D was similar to that of resveratrol and ascorbic acid in the following assays: ABTS, O2*-, and HOCl. The scavenging capacity of ascorbic acid for DPPH was higher than that of both geranins and resveratrol. On the other hand, the OH* scavenging action of both geranins and resveratrol was similar. The methanol-CHCl3 (1:1) extract had a higher ability to scavenge ABTS, DPPH, and O2*- radicals than the chloroform extract. In turn, the latter was more potent than the methanol-CHCl3 (1:1) extract as OH* or HOCl scavenger agent. Neither geranins A and D nor the extracts were able to scavenge H2O2 and (1)O2. In conclusion, G. niveum roots have proanthocyanidins with powerful radical scavenging in vitro activity. This property may partially explain the wide use of this plant in the Tarahumara indigenous system of medicine for the treatment of gastrointestinal illnesses (other than spasms), pain, and fevers associated with oxidative stress.  相似文献