Canine ocular and periocular snakebites requiring enucleation: A report of 19 cases     

Erin M. Scott  Brittany N. Schlesener  Gillian C. Shaw  Leandro B. C. Teixeira 《Veterinary ophthalmology》2019,22(5):666-673

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The future of canine glaucoma therapy     

Andrs M. Komromy  Dineli Bras  Douglas W. Esson  Ronald L. Fellman  Sinisa D. Grozdanic  Larry Kagemann  Paul E. Miller  Sayoko E. Moroi  Caryn E. Plummer  John S. Sapienza  Eric S. Storey  Leandro B. Teixeira  Carol B. Toris  Terah R. Webb 《Veterinary ophthalmology》2019,22(5):726-740

Canine glaucoma is a group of disorders that are generally associated with increased intraocular pressure (IOP) resulting in a characteristic optic neuropathy. Glaucoma is a leading cause of irreversible vision loss in dogs and may be either primary or secondary. Despite the growing spectrum of medical and surgical therapies, there is no cure, and many affected dogs go blind. Often eyes are enucleated because of painfully high, uncontrollable IOP. While progressive vision loss due to primary glaucoma is considered preventable in some humans, this is mostly not true for dogs. There is an urgent need for more effective, affordable treatment options. Because newly developed glaucoma medications are emerging at a very slow rate and may not be effective in dogs, work toward improving surgical options may be the most rewarding approach in the near term. This Viewpoint Article summarizes the discussions and recommended research strategies of both a Think Tank and a Consortium focused on the development of more effective therapies for canine glaucoma; both were organized and funded by the American College of Veterinary Ophthalmologists Vision for Animals Foundation (ACVO‐VAF). The recommendations consist of (a) better understanding of disease mechanisms, (b) early glaucoma diagnosis and disease staging, (c) optimization of IOP‐lowering medical treatment, (d) new surgical therapies to control IOP, and (e) novel treatment strategies, such as gene and stem cell therapies, neuroprotection, and neuroregeneration. In order to address these needs, increases in research funding specifically focused on canine glaucoma are necessary.  相似文献   

Evaluation and comparison of postoperative analgesic effects of dexketoprofen and methadone in dogs     

Álvaro J. Gutiérrez-Bautista  Juan Morgaz  María del Mar Granados  Rafael J. Gómez-Villamandos  Juan M. Dominguez  José A. Fernandez-Sarmiento  Daniel Aguilar-García  Rocío Navarrete-Calvo 《Veterinary anaesthesia and analgesia》2018,45(6):820-830

Objective

To evaluate and compare the analgesic efficacy and adverse effects of dexketoprofen and methadone using a noninferiority trial, during the first 24 postoperative hours in dogs undergoing orthopaedic surgery.

Study design

Randomized, blinded clinical study.

Animals

A total of 38 healthy dogs undergoing orthopaedic surgery.

Methods

Dogs were premedicated with dexmedetomidine [1 μg kg^–1 intravenously (IV)] followed by dexketoprofen (1 mg kg^–1 IV; group DK) or methadone (0.2 mg kg^–1 IV; group M). Anaesthesia was induced with propofol and maintained with isoflurane in 60% oxygen. Postoperatively, dexketoprofen was administered every 8 hours (group DK) and methadone every 4 hours (group M). Analgesia was assessed at baseline and at 1, 2, 4, 6, 18 and 24 hours after extubation using a dynamic and interactive visual analogue scale (DIVAS), the short form of the Glasgow Composite Measure Pain Scale (CMPS-SF), mechanical wound thresholds (MWTs) and plasma cortisol levels. If CMPS-SF score was ≥5, rescue analgesia was administered. Data were analysed using a general linear mixed model, Mann–Whitney U test and chi-squared test as appropriate; a p value <0.05 was considered significant.

Results

The CMPS-SF and DIVAS scores were significantly higher in group M compared with group DK and remained higher for a longer period in group M, although the differences were not clinically significant. No significant differences were found in MWT assessment between groups. Plasma cortisol level significantly increased 2 hours after extubation, without significant differences between treatments. Rescue analgesia was administered to three animals (one in group DK; two in group M).

Conclusion and clinical relevance

We conclude that 1 mg kg^–1 IV dexketoprofen administered every 8 hours during the first 24 hours postoperatively is noninferior to methadone in controlling pain after orthopaedic surgery in dog, although frequent pain assessments are recommended to adjust the analgesia plan.  相似文献   

Description of an ultrasound-guided thoracic paravertebral block technique and the spread of dye in dog cadavers     

Tatiana H. Ferreira  Leandro B.C. Teixeira  Carrie A. Schroeder  Cristina de Miguel Garcia  Kristopher M. Schroeder 《Veterinary anaesthesia and analgesia》2018,45(6):811-819

Objectives

To describe an ultrasound-guided thoracic paravertebral block and determine the distribution after injection of two volumes of methylene blue in dog cadavers.

Study design

Prospective experimental cadaveric study.

Animals

Twelve dog cadavers weighing 11 ± 3 kg.

Methods

Ultrasound-guided injections aimed at the fifth thoracic (T5) paravertebral space were performed in randomized order using 0.1 or 0.3 mL kg^–1 dye solution (six dogs for each volume). Anatomic dissections determined dye spread characteristics, including the presence and degree of staining of spinal nerves, and the presence of intercostal and sympathetic trunk spread. Staining of mediastinum, epidural, intrapleural and contralateral thoracic paravertebral space was recorded.

Results

There was no significant difference in dye distribution between groups. The use of anatomic landmarks resulted in the inaccurate identification of the T5 paravertebral space. The T4, T5 and T6 paravertebral spaces were injected in four, five and three of 12 dogs, respectively. Complete staining of the spinal nerve of the thoracic paravertebral space injected was observed in 11 of 12 dogs, and partial staining in one dog in the low-volume group. Multisegmental distribution was demonstrated with staining of contiguous spinal nerves in one dog in the high-volume group, and multiple segments of intercostal (three dogs) and sympathetic trunk (four dogs) spread in both groups. No mediastinal, epidural, intrapleural or contralateral thoracic paravertebral space staining was observed.

Conclusions and clinical relevance

Ultrasound-guided injection at the thoracic paravertebral space resulted in staining of the spinal nerve in all dogs. However, T5 paravertebral space was not accurately identified using anatomic landmarks. Dye distribution was not significantly different between the two groups; therefore, the use of the lower-volume and multiple-site injections would be potentially necessary in clinical cases to achieve ipsilateral blockade of the thoracic wall.  相似文献   

Iridociliary cysts masquerading as neoplasia in cats: a morphologic review of 14 cases          下载免费PDF全文

Jessica A. Fragola  Richard R. Dubielzig  Ellison Bentley  Leandro B. C. Teixeira 《Veterinary ophthalmology》2018,21(2):125-131

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Uveal schwannoma in a brown‐eyed dog          下载免费PDF全文

Todd L. Marlo  Elizabeth A. Giuliano  Cecil P. Moore  Gillian C. Shaw  Leandro B. C. Teixeira 《Veterinary ophthalmology》2018,21(2):205-209

An eleven‐year‐old, female spayed Boxer dog was diagnosed with a uveal schwannoma (formerly known as the spindle cell tumor of the blue‐eyed dog or SCTBED) despite having a uniformly brown iris. The patient presented to emergency for ocular discomfort, and the right globe was subsequently enucleated due to glaucoma and submitted for histopathology. Upon histopathologic evaluation, a uveal schwannoma was diagnosed and confirmed with immunohistochemical staining. Complete metastatic evaluation 1 and 6 months after initial presentation did not reveal evidence of metastasis, and the dog remains systemically healthy. This case represents a unique variant of uveal schwannoma and is relevant because although the vast majority of these tumors occur in blue‐eyed dogs, clinicians should not completely rule out this tumor as a differential based on the iris color.  相似文献   

Proteome of the periovulatory oviduct and uterus of goats as related to nutritional balance          下载免费PDF全文

César Carneiro Linhares Fernandes  Paula Rodriguez‐Villamil  Fábio Roger Vasconcelos  Celso Shiniti Nagano  Rafael Rossetto  Arlindo de Alencar Araripe Noronha Moura  Davide Rondina 《Reproduction in domestic animals》2018,53(5):1085-1095

This study was conducted to evaluate the effects of different feeding levels on the proteome of oviduct and uterus tissues of hormonally stimulated goats during the periovulatory period. Forty goats were separated into four different diet groups: Diet 1.0 M (n = 11), Diet 1.3 M (n = 10), Diet 1.6 M (n = 9), Diet 1.9 M (n = 10), fed with 1.0, 1.3, 1.6 and 1.9 times live weight maintenance, respectively. After four weeks of treatment, six hormonally stimulated females per treatment group were randomly selected for collection of uterine and the oviduct tissue samples. Samples were collected after animals were slaughtered in a commercial unit. Feeding goats with 1.3 to 1.9 times more nutrients than a control group directly influenced the proteome of the oviduct and uterus, altering the expression of proteins that participate in biological processes such as apoptosis, antioxidant, and immunological activities. These events are crucial for fertilization and early embryonic survival. Expression of oviduct proteins such as Tubulin Beta 2B, Transferrin and Disulphide‐isomerase A3 increased in the 1.9 M group in relation to the other feeding levels. Disulphide‐isomerase A4 showed higher expression in the 1.0 M group compared to diets with higher energetic levels. As energy intake increased in the diets, there was higher expression of Alpha‐1‐antitrypsin and downregulation of Profilin‐1 in the uterus of the goats. In conclusion, this study showed that specific proteins of the goat oviduct and uterus expressed during the periovulatory period are modified as the result of nutritional balance.  相似文献   

Intake,digestibility, growth performance,and enteric methane emission of Brazilian semiarid non-descript breed goats fed diets with different forage to concentrate ratios     

Aynoanne Leandro Barbosa  Tadeu Vinhas Voltolini  Daniel Ribeiro Menezes  Salete Alves de Moraes  Julio Cesar Silva Nascimento  Rafael Torres de Souza Rodrigues 《Tropical animal health and production》2018,50(2):283-289

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Body composition and energy and protein nutritional requirements for weight gain in Santa Ines crossbred sheep     

Darley Oliveira Cutrim  Kaliandra Souza Alves  Rozilda da Conceição dos Santos  Vanessa Jaqueline Veloso da Mata  Luis Rennan Sampaio Oliveira  Daiany Íris Gomes  Rafael Mezzomo 《Tropical animal health and production》2016,48(3):683-688

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Performance of crossbred heifers in different step-down waste milk-feeding strategies     

Juliana Mergh Leão  Juliana Aparecida Mello Lima  Ângela Maria Quintão Lana  Helton Mattana Saturnino  Ronaldo Braga Reis  Fabiano Alvim Barbosa  Rafael Alves de Azevedo  Robson Vilela Sá Fortes  Sandra Gesteira Coelho 《Tropical animal health and production》2016,48(8):1607-1612

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