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11.
MAGNETIC RESONANCE IMAGING IN THE DIAGNOSIS OF FOCAL GRANULOMATOUS MENINGOENCEPHALITIS IN TWO DOGS 总被引：1，自引：0，他引：1
Two dogs with neurologic signs were evaluated by magnetic resonance imaging of the brain. Focal space-occupying lesions were present in both dogs. In the first, the lesion was in the brain stem and in the second, in the cerebellum. In one dog the lesion was only evident after administration of gadolinium-DTPA-dimeglumine. Based on the magnetic resonance images, neoplasia was suspected in both dogs but histopathologically, granulomatous meningoencephalomyelitis was diagnosed. 相似文献
12.
Nel M Lobetti RG Keller N Thompson PN 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2004,18(4):471-476
Canine babesiosis typically causes hemolytic anemia but also can result in multiple organ dysfunction. Human patients with severe disease often have persistent hyperlactatemia, and blood lactate concentration is correlated with survival rate. In dogs, blood lactate concentration has been shown to be of prognostic value in patients with gastric dilatation-volvulus and in dogs admitted to intensive care units. Serial blood lactate and glucose concentrations and hematocrit on admission were determined in 90 dogs with naturally occurring, severe or complicated canine babesiosis. Forty-five dogs (50%) had hyperlactatemia (blood lactate concentration >22.5 mg/dL) and 20 (22.2%) had hypoglycemia (blood glucose concentration <59.4 mg/dL) at presentation. Measurements significantly associated with mortality were hypoglycemia on admission, blood lactate concentration >45 mg/dL on admission, blood lactate concentration >22.5 mg/dL at 8, 16, and 24 hours after admission, and increase or <50% decrease in blood lactate concentration within 8 and 16 hours after admission. Blood lactate concentration persistently >40 mg/dL indicated a very poor prognosis. We conclude that serial blood lactate measurements are useful in predicting survival in dogs with severe and complicated canine babesiosis. 相似文献
13.
OBJECTIVE: To document changes in glucose, lactate, and pyruvate concentrations in dogs with severe or complicated babesiosis; assess relationships among glucose, lactate, and pyruvate concentrations in those dogs; and compare clinical and laboratory variables in dogs with and without hypoglycemia and hyperlactatemia. ANIMALS: 20 dogs with naturally developing severe or complicated babesiosis. PROCEDURE: Samples and measurements were obtained before treatment was initiated. Babesiosis was diagnosed by examination of blood smears. Arterial blood pressure measurement, parasite quantification, CBC count, serum biochemical analysis, urinalysis, venous blood gas analysis, and acid-base determination were performed. Glucose, lactate, and pyruvate concentrations were measured in samples of venous blood. RESULTS: We detected a significant negative correlation between glucose and lactate concentrations. Glucose, lactate, and pyruvate concentrations all differed significantly between dogs that died and those that survived. Three of 5 dogs that died had concurrent hypoglycemia, hyperlactatemia, and hyperpyruvatemia. Hypoglycemic dogs differed significantly from normoglycemic dogs with regard to lactate, urea, and bicarbonate concentrations; lactate-to-pyruvate ratio; percentage parasitemia; and PCO2. Dogs with hyperlactatemia differed significantly from normolactatemic dogs with regard to clinical collapse; alanine transaminase activity; concentrations of bilirubin, urea, creatinine, and bicarbonate; percentage parasitemia; and PCO2. CONCLUSIONS AND CLINICAL RELEVANCE: Abnormal carbohydrate metabolism is commonly evident in dogs with severe or complicated babesiosis and is often associated with changes in other clinical and laboratory variables. Significant differences were found between survivors and nonsurvivors. Hypoglycemia should be assessed and aggressively treated in dogs with babesiosis. Lactate concentration can be used as an indicator of disease severity. 相似文献
14.
Lobetti R 《Veterinary journal (London, England : 1997)》2012,193(1):277-278
The purpose of this study was to evaluate the effect of a daily oral dose of doramectin in dogs with spirocercosis. Twenty naturally infected dogs were treated with 0.5 mg/kg doramectin administered orally once daily for 42 days. In 13 of the dogs there was resolution of the nodules after 42 days. Nodules were eliminated in five of the remaining seven dogs following treatment for an additional 42 days. In the remaining two dogs, treatment continued for a further 42 days (total 126 days), resulting in complete resolution. No adverse events associated with treatment were observed. This study concluded that doramectin at 0.5 mg/kg once a day is effective in the elimination of Spirocerca lupi nodules in dogs. 相似文献
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16.
Anna Arnold Eliseo Betto Gandolfina Farina Attilio Formigoni Remo Galli Lucio Merlini 《Pest management science》1984,15(3):303-309
Twenty-three aromatic or heterocyclic 1,1-disubstituted-but-3-yn-1-ols were prepared by the reaction between prop-2-ynylmagnesium bromide and suitable ketones. They were tested in vivo for antifungal activity against eight phytopathogenic fungi of different taxonomic classes. Four compounds had noteworthy activity on Sphaerotheca fuliginea in protectant, systemic and eradicant assays. The relationship between structure and activity is discussed on the basis of the recent hypotheses on the mechanism of action of ergosterol biosynthesis inhibitors. 相似文献
17.
We reported earlier that somaclonal variant HS (HS), regenerated from Prunus avium `Hedelfinger’ (H) leaf explants, showed reduced apical dominance both in vitro and in vivo. In this report we found that
the somaclone HS, showed reduced vegetative vigour as determined by trunk circumference and tree height nevertheless natural
architecture of the tree was preserved. HS canopy was less crowded as to compare to H and leaves were shorter with a shorter
petiole, they were better spaced out as indicated by internodes length. HS had a significantly thinner cuticle and wax layer
compared to H leaves surface. Histological analysis of leaves also showed that HS had thicker mesophyll and palisade the latter
composed of more than one layer which, together with increased stomatal density, are distinguishing signs of extensive exposure
of leaves to sun. Chlorophyll a and chlorophyll b content did not differ between H and HS, β-carotene content was slightly
lower in HS leaves. However no significant differences were found between the two genotypes in terms of net photosynthesis,
intercellular CO2 concentration, leaf transpiration and water use efficiency. HS flowered 1-year later than H and number of flowers was reduced.
Fruit size, shape, skin colour change during the ripening process and the main parameters of fruit quality as assessed in
the wild type and the somaclone were basically the same. 相似文献
18.
Linda S Jacobson Remo G Lobetti Pieter Becker Fred Reyers Tarquin Vaughan-Scott 《Veterinary parasitology》2002,104(1):27-41
Babesiosis, caused by the virulent haemoprotozoan parasite Babesia canis rossi, is an important disease of dogs in South Africa. The nitric oxide metabolites, nitrate and nitrite (collectively termed reactive nitrogen intermediates or RNIs) were measured in admission sera from dogs in a babesiosis-endemic area. Five groups were prospectively studied: mild uncomplicated (n=9), severe uncomplicated (severe anaemia) (n=10) and complicated babesiosis (n=11); and two groups of healthy aparasitaemic dogs: endemic controls from the study area (n=10) and experimental dogs kept in tick-free conditions (n=10). Four measures of RNI production were studied: (i) serum RNI; (ii) serum RNI/creatinine ratio; (iii) fractional clearance of RNI (FC(RNI)); (iv) fractional excretion of RNI (FE(RNI)). Marked elevations of serum RNI occurred in only two dogs, both in the severe uncomplicated group. The highest concentration (log value 5.29 micromol/l) was in a dog that died, but concentrations in the other four dogs that died were unremarkable (0, 0.34, 1.66 and 2.64 micromol/l). Age, appetite and free serum haemoglobin were significant covariates for measures of RNI production. There were no significant differences among the babesiosis groups for serum RNI. Adjustment for creatinine had minor effects on the results. All babesiosis groups had significantly higher serum RNI and RNI/creatinine than the tick-free control group, but did not differ from the endemic controls except for the severe uncomplicated group, which had higher RNI/creatinine. The complicated group had significantly lower FC(RNI) and FE(RNI) than all other groups, except for the tick-free control group, which had similar FE(RNI). The results indicate that, in an endemic area, measures of RNI production are unlikely to be useful indicators of severity or outcome in canine babesiosis. 相似文献
19.
Bacterial colonization of intravenous catheters in young dogs suspected to have parvoviral enteritis
Lobetti RG Joubert KE Picard J Carstens J Pretorius E 《Journal of the American Veterinary Medical Association》2002,220(9):1321-1324
OBJECTIVE: To determine the prevalence of bacterial colonization of IV catheters among young dogs suspected to have parvoviral enteritis, to identify the organisms responsible for catheter colonization, and to determine the antimicrobial susceptibility of organisms that were obtained. DESIGN: Case series. ANIMALS: 100 dogs. PROCEDURE: Catheters were aseptically removed when fluid therapy was discontinued, the catheter was replaced, or the dog died. The distal tip of the catheter was cut off, split open, and vortexed with sterile saline (0.9% NaCl) solution. The saline solution was plated on culture plates, which were then incubated and examined for bacterial growth every 24 hours for 72 hours. All bacteria cultured were identified, and antimicrobial susceptibility was determined. RESULTS: Bacteria were isolated from 22 catheters. Most bacteria that were isolated were of gastrointestinal tract or environmental origin (Serratia odorifera, S. liquefaciens, S. marcescens, Acinobacter anitratus, Citrobacter freundii, Klebsiella pneumoniae, K. oxytoca, Escherichia coli, Enterobacter spp). Only 2 gram-positive organisms were isolated (Staphylococcus intermedius and Streptococcus spp). High percentages of organisms were resistant to penicillin, lincomycin, cloxacillin, erythromycin, and cephalexin. Percentages of organisms resistant to amikacin, enrofloxacin, chloramphenicol, potentiated sulfonamides, and amoxicillin-clavulanic acid were low. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that IV catheters may be colonized with bacteria in 22% of young dogs suspected to have parvovirus infection. 相似文献
20.
E. N. Smitsaart M. Zanelli I. Rivera N. Fondevila D. Compaired E. Maradei T. Bianchi V. O''Donnell A. A. Schudel 《Preventive veterinary medicine》1998,33(1-4):283-296
The development of a liquid-phase blocking sandwich ELISA (LPBE) to measure antibodies (Ab) produced in cattle with the O, A and C foot-and-mouth disease virus (FMDV) types of commercial vaccines used in Argentina is described. The test was specific: 99% of naïve cattle sera (n = 130) gave titres below log10 = 1.2, and none had a titre above log10 = 1.5. Comparative studies with serum neutralization test (SNT) using sera from cattle which received one or more vaccine doses is reported. The overall rank correlation coefficient (Spearman's , rs) between SNT and LPBE were highly significant (rs > 0.67, P < 0.0001) for all vaccine strains. LBPE Ab titres on sera collected 90 days post vaccination were compared with results of cattle protection tests by applying a logistic regression. The minimum Ab titres at which 85% and 75% of the cattle were protected for each FMDV type were determined in order to interpret field Ab data in terms of protection. Application of this method allows large scale serological examinations to monitor antibody levels in vaccinated animals as an indirect indicator of the FMD control program status in the field. Its use in the evaluation of commercial batches of FMD vaccine is discussed. 相似文献