Antidiabetic activity evaluation of glimepiride and Nerium oleander extract on insulin, glucose levels and some liver enzymes activities in experimental diabetic rat model     

Mwafy SN  Yassin MM 《Pakistan journal of biological sciences: PJBS》2011,14(21):984-990

The present study is aimed to assess the therapeutic potential of sulfonylurea drug glimepiride in comparison with Nerium oleander plant extract on insulin, glucose levels and some liver enzymes activities in streptozotocin-induced diabetic rats. Rats were rendered diabetic by intraperitoneal injection of a single dose of 50 mg kg(-1) body weight streptozotocin. Rats with serum glucose levels > 200 mg dL(-1) were subdivided into three sub-groups: the first sub-group were remained without treatment and considered as diabetics. The second and third subgroups were orally administered 0.1 mg kg(-1) body weight/day glimepiride and 250 mg kg(-1) body weight/day Nerium oleander, respectively for 4 weeks. Streptozotocin-induced diabetic rats showed hypoinsulinemia and hyperglycemia compared to controls. Strong negative correlation (r = -0.8) was found between serum insulin and glucose levels in diabetic rats. This correlation was +0.4 and -0.3 in glimepiride and Nerium olender-treated rats, respectively implying that glimepiride and plant extract improved insulin and glucose levels with the former was more efficient. The activities of serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase were significantly increased in streptozotocin-induced diabetic rats compared to controls. Treatment of diabetic rats with glimepiride or Nerium oleander extract also improved liver enzymes activities.  相似文献   

The biological effects of three insect growth regulators onCulex pipiens L     

Professor M. S. Saleh  M. I. Aly 《Journal of pest science》1987,60(2):34-37

Tests were made to determine the possible juvenilizing effects of three insect growth regulators (IGRs) namely, IKI 7899, SIR 8514 and Dowco 439 on immature stages and adults ofCulex pipiens L. using the IC₅₀ values (concentration to inhibit the emergence of 50% of adults) as a criterion. The results indicated that IKI 7899 (0.00031 μg/ml) proved to be the most effective compound followed by SIR 8514 (0.0052 μ/ml) and Dowco 439 (0.029 μg/ml). Apart from lethal action, treatment of fourth larval instars with the IC₂₅ values (concentration to inhibit the emergence of 25% of adults) of the above-mentioned IGRs affected the reproductive capacity of surviving adults. Moreover, larval treatments with these compounds led to a marked prolongation in the duration of first gonotrophic cycle. There was also an increase in the proportion of survived females/males ofC. pipiens after these larval treatments.  相似文献   

Laboratory and field evaluation of the pathogenicity of entomopathogenic nematodes to the red palm weevil, Rhynchophorus ferrugineus (Oliv.) (Col.: Curculionidae)     

M. S. T. Abbas  M. M. E. Saleh  A. M. Akil 《Journal of pest science》2001,74(6):167-168

Ten Egyptian and imported entomopathogenic nematodes were evaluated for their pathogenicity to R. ferrugineus in both the laboratory and the field. In the laboratory, most nematodes were pathogenic to the pest larvae, pupae and adults. Larvae and adults were more susceptible to nematode infection (mostly 100?% mortality) than pupae enclosed in their cocoons. In the field however, the highest insect larval mortality was 66.67?% and most of nematodes failed in controlling the pest. Such failure could be due to hot weather, the tunnelling behaviour of the pest larvae and the too much sap in the infested sites in the trunks of palm trees.  相似文献   

Effect of larval selection with two bioinsecticides on susceptibility levels and reproductive capacity ofAedes aegypti (L.)     

Dr. Moustafa S. Saleh 《Journal of pest science》1987,60(3):55-57

Two bacterial insecticides,Bacillus thuringiensis H-14 andB. sphaericus 1593 were evaluated for larvicidal potency against mosquito larvae ofAedes aegypti. LC₅₀ values showed thatB.thuringiensis H-14 (4×10⁵ spores/ml) had a higher pathogenicity against fourth larval instars ofA. aegypti thanB. sphaericus (3.1×10⁶ spores/ml) by about 7.75 times. Larval selection with LC₉₀ of both pathogens for 8 successive generations caused a decrease in the susceptibility levels of selected strains ofA. aegypti as compared with the original strain. Moreover, the results indicated that the effect of larval selection with the above bioinsecticides led to an obvious reduction in the egg production and hatchability of eggs produced by mosquito adults that developed from surviving larvae.  相似文献   

Antioxidant capacity,antioxidant compounds and antioxidant enzyme activities in five date cultivars during development and ripening     

Mohamed A. Awad  Adel D. Al-Qurashi  Saleh A. Mohamed 《Scientia Horticulturae》2011

Antioxidant capacity, antioxidant compounds and antioxidant enzyme activities in dates of five cultivars during development and ripening were studied in the 2009 and 2010 seasons. Fruit growth followed a smooth sigmoid curve with maximum weight at the bisir stage. Both the antioxidant capacity measured by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method and the antioxidant compound (phenols, tannins and vitamin C) concentrations decreased from young stages through to the maturation and the ripening stages. The antioxidant capacity was highly positively correlated with the concentration of antioxidant compounds in most cultivars. The activities of the antioxidant enzymes, peroxidase, catalase and polyphenoloxidase (PPO) increased from the hababouk through to the kimri and/or the bisir stage, upon cultivar, and thereafter, declined at the ripening stages. The possible relation of these biochemical changes with fruit maturation and ripening was discussed.  相似文献   

Corn yield response to crowding stress and cropping season     

Hassan Mokhtarpour  Christopher Teh  Ghizan Saleh  Ahmad Selamat  Mohammad Esmail Asadi  Behnam Kamkar 《Archives of Agronomy and Soil Science》2013,59(8):853-871

Corn (Zea mays L.) is planted in two seasons per year in northern Iran (mid-April as a main crop and mid-June as a second crop). The main objective of this study was to determine whether corn yield response would differ between these two seasons and different plant populations. Two field experiments were conducted at the Agricultural Research Center of Golestan – Iran in 2007 and 2008 at different planting densities. The results showed that the values of grain yield and most traits were significantly lower in the second season. Maximum grain yield was observed at planting densities of 6.5 plants m^?2 in the first season, whereas in the second season grain yield was the same for planting densities between 2.5 and 12.5 plants m^?2. Based on the second-year experimental results, the following functions were fitted to show the relationship between yield ha^?1 (Y) and planting densities (X) for the first and second seasons, respectively: (Y = ?167.6X ² + 2672.2X + 511.77; R ² = 0.992) and (Y = 1200.1 ln(X) + 2924.4; R ² = 0.935). This study found that the optimum plant population was 6.5 plants m^?2 under low heat stress, and should be reduced to 2.5–4.5 plants m^?2 under heat stress conditions.  相似文献   

Additions to plant diseases recorded in the Yemen Arab Republic     

M. Kamal  K. M. Ahmed  Saleh el Makaleh 《国际虫害防治杂志》2013,59(4):434-435

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Quantitative Changes in Protein and Cholesterol in Haemolymph of the Red Palm Weevil Rhynchophorus ferrugineus after Treatment Leucokininll     

Mona Mohammed  Saleh  A-Dawsary 《农业科学与技术》2013,(2):140-145

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Laboratory and field evaluation of the pathogenicity of entomopathogenic nematodes to the red palm weevil, Rhynchophorus ferrugineus (Oliv.) (Col.: Curculionidae)     

M. S. T. Abbas  M. M. E. Saleh  A. M. Akil 《Anzeiger für Sch?dlingskunde》2001,74(6):167-168

Ten Egyptian and imported entomopathogenic nematodes were evaluated for their pathogenicity to R. ferrugineus in both the laboratory and the field. In the laboratory, most nematodes were pathogenic to the pest larvae, pupae and adults. Larvae and adults were more susceptible to nematode infection (mostly 100% mortality) than pupae enclosed in their cocoons. In the field however, the highest insect larval mortality was 66.67% and most of nematodes failed in controlling the pest. Such failure could be due to hot weather, the tunnelling behaviour of the pest larvae and the too much sap in the infested sites in the trunks of palm trees.  相似文献   

Surface Ultrastructure of Ultimobranchial Epithelium in the Thyroid Gland of Donkey (Equus asinus)     

R. Sayed    W. Mubarak    A. M. Saleh 《Anatomia, histologia, embryologia》2005,34(S1):45-46

Surface ultrastructural observation of the thyroid gland in donkey revealed the coexistence of certain unusual follicles or cysts, the ultimobranchial (UB) follicles, which exhibited large diameters and less regular outlines. In addition, several small follicles, cell nests or solid cellular masses were also demonstrated in association with these structures. Surface of most UB follicular cells was almost hexagonal in shape, studded with sparse or dense pleomorphic microvilli, which were much denser at the cellular borders. Each follicular cell bore single cilium that projecting over the cell surface. Interestingly, bleb-like apocrine protrusion of the apical cytoplasm of some follicular cells was frequently demonstrated. These apocrine blebs (or aposomes) were varied in shape, size and showed smooth or irregular surface. In addition to such aposomes, deep to shallow circumscribed or eroded areas of the apical cell surface was frequently demonstrated. These findings indicate that the UB follicular cells in donkeys, similar to those of camels, exhibit an apocrine activity alongside with the usual merocrine mode of secretion.  相似文献