Receptors: localization and specificity of binding of serotonin in the central nervous system   总被引：2，自引：0，他引：2  

S G Alivisatos  F Ungar  P K Seth  L P Levitt  A J Geroulis  T S Meyer 《Science (New York, N.Y.)》1971,171(973):809-812

Formation of a Schiff base between the ethylamine residue of serotonin and an appropriate carbonyl residue at the receptor site may be among the forces holding serotonin onto the receptor. Reduction of this imine may provide a means of permanently labeling receptors as a preliminary to their isolation.  相似文献   

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88   总被引：1，自引：0，他引：1  

Rakoff-Nahoum S  Medzhitov R 《Science (New York, N.Y.)》2007,317(5834):124-127

Inflammation is increasingly recognized as an important component of tumorigenesis, although the mechanisms and pathways involved are not well understood. Tumor development is regulated by products of several modifier genes, but instructions for their tumor-specific expression are currently unknown. We show that the signaling through the adaptor protein MyD88 has a critical role in spontaneous tumor development in mice with heterozygous mutation in the adenomatous polyposis coli (APC) gene. We found that MyD88-dependent signaling controls the expression of several key modifier genes of intestinal tumorigenesis and has a critical role in both spontaneous and carcinogen-induced tumor development. This study thus reveals the important role of an innate immune signaling pathway in intestinal tumorigenesis.  相似文献   

Holocene deglaciation of Marie Byrd Land,West Antarctica     

Stone JO  Balco GA  Sugden DE  Caffee MW  Sass LC  Cowdery SG  Siddoway C 《Science (New York, N.Y.)》2003,299(5603):99-102

Surface exposure ages of glacial deposits in the Ford Ranges of western Marie Byrd Land indicate continuous thinning of the West Antarctic Ice Sheet by more than 700 meters near the coast throughout the past 10,000 years. Deglaciation lagged the disappearance of ice sheets in the Northern Hemisphere by thousands of years and may still be under way. These results provide further evidence that parts of the West Antarctic Ice Sheet are on a long-term trajectory of decline. West Antarctic melting contributed water to the oceans in the late Holocene and may continue to do so in the future.  相似文献   

Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling     

Major MB  Camp ND  Berndt JD  Yi X  Goldenberg SJ  Hubbert C  Biechele TL  Gingras AC  Zheng N  Maccoss MJ  Angers S  Moon RT 《Science (New York, N.Y.)》2007,316(5827):1043-1046

  相似文献   

Small bilaterian fossils from 40 to 55 million years before the cambrian   总被引：1，自引：0，他引：1  

Chen JY  Bottjer DJ  Oliveri P  Dornbos SQ  Gao F  Ruffins S  Chi H  Li CW  Davidson EH 《Science (New York, N.Y.)》2004,305(5681):218-222

Ten phosphatized specimens of a small (<180 micrometers) animal displaying clear bilaterian features have been recovered from the Doushantuo Formation, China, dating from 40 to 55 million years before the Cambrian. Seen in sections, this animal (Vernanimalcula guizhouena gen. et sp. nov.) had paired coeloms extending the length of the gut; paired external pits that could be sense organs; bilateral, anterior-posterior organization; a ventrally directed anterior mouth with thick walled pharynx; and a triploblastic structure. The structural complexity is that of an adult rather than a larval form. These fossils provide the first evidence confirming the phylogenetic inference that Bilateria arose well before the Cambrian.  相似文献   

Astronomy. Gathering interstellar gas     

Redfield S 《Science (New York, N.Y.)》2012,336(6086):1243-1244

  相似文献   

Feline pituitary-dependent hyperadrenocorticism and insulin resistance due to a plurihormonal adenoma     

Cross E  Moreland R  Wallack S 《Topics in companion animal medicine》2012,27(1):8-20

A 12-year-old female spayed domestic short-haired cat presented for lethargy, poor hair coat, alopecia, difficulty walking, and mild polyuria/polydipsia. The cat's skin tore easily in the neck area during routine restraint for blood draw. Physical examination, blood analysis, and ultrasound imaging were all consistent with pituitary-dependent hyperadrenocorticism (PDH) with secondary insulin-resistant diabetes mellitus, which was nonketotic. Insulin therapy, fluids, and diet change were initiated for the diabetes mellitus and the owner reported improvement in clinical signs although the blood glucose measurements remained elevated. Surgical repair of the torn skin was successful. Although a guarded prognosis was given to the owner because of an advanced stage of hyperadrenocorticism, and the limited treatment options currently available for feline PDH, trilostane was agreed on as an initial therapeutic option. The day trilostane was to be initiated, the cat presented with dyspnea and the owner chose to euthanize. Because of the rarity of hyperadrenocorticism disease in the cat, permission was obtained by the owner for a necropsy to confirm suspected PDH as the underlying cause for insulin resistance and skin fragility syndrome.  相似文献   

The Relationship Between Ski Patrols and Emergency Medical Services Systems     

Seth C. Hawkins 《The Forestry Chronicle》2012,23(2):106-111

  相似文献   

Greater Sage-Grouse and Severe Winter Conditions: Identifying Habitat for Conservation     

Matthew R. Dzialak  Stephen L. Webb  Seth M. Harju  Chad V. Olson  Jeffrey B. Winstead  Larry D. Hayden-Wing 《Strength and Conditioning Journal》2013,66(1):10-18

Developing sustainable rangeland management strategies requires solution-driven research that addresses ecological issues within the context of regionally important socioeconomic concerns. A key sustainability issue in many regions of the world is conserving habitat that buffers animal populations from climatic variability, including seasonal deviation from long-term precipitation or temperature averages, and that can establish an ecological bottleneck by which the landscape-level availability of critical resources becomes limited. We integrated methods to collect landscape-level animal occurrence data during severe winter conditions with estimation and validation of a resource selection function, with the larger goal of developing spatially explicit guidance for rangeland habitat conservation. The investigation involved greater sage-grouse (Centrocercus urophasianus) that occupy a landscape that is undergoing human modification for development of energy resources. We refined spatial predictions by exploring how reductions in the availability of sagebrush (as a consequence of increasing snow depth) may affect patterns of predicted occurrence. Occurrence of sage-grouse reflected landscape-level selection for big sagebrush, taller shrubs, and favorable thermal conditions and avoidance of bare ground and anthropogenic features. Refinement of spatial predictions showed that important severe winter habitat was distributed patchily and was constrained in spatial extent (7–18% of the landscape). The mapping tools we developed offer spatially explicit guidance for planning human activity in ways that are compatible with sustaining habitat that functions disproportionately in population persistence relative to its spatial extent or frequency of use. Increasingly, place-based, quantitative investigations that aim to develop solutions to landscape sustainability issues will be needed to keep pace with human-modification of rangeland and uncertainty associated with global climate change and its effects on animal populations.  相似文献   

Duncan & Prasse's Veterinary Laboratory Medicine: Clinical Pathology, 5th EditionEditor: KennethS. LatimerPublisher: Wiley‐Blackwell,Ames IA,ISBN: 978‐0‐8138‐2014‐9hardcover: 524 pages, 2011, $79.99     

Seth E. Chapman DVM  MS  DACVP 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2013,42(2):246-246

  相似文献