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81.
Gage KS McAfee JR Carter DA Ecklund WL Riddle AC Reid GC Balsley BB 《Science (New York, N.Y.)》1991,254(5039):1771-1773
Measurement from Christmas Island (2 degrees N, 157 degrees W) of long-term mean vertical motions in the tropical atmosphere using very-high-frequency wind-profiling Doppler radar show that there is a transition from downward motion in the free troposphere to upward motion in the upper troposphere and lower stratosphere. The observations in the free troposphere are consistent with a balance between adiabatic and diabatic heating and cooling rates in a clear atmosphere. Comparison of the results at Christmas Island during El Ni?o and non-El Ni?o conditions with earlier results obtained for stratiform rain conditions over Pohnpei, Federated States of Micronesia, show that cirrus clouds in the vicinity of the tropopause likely play an important role in determining the sense and magnitude of vertical motions in this region. These results have implications for the exchange of mass between the troposphere and stratosphere over the tropics. 相似文献
82.
Genetically determined sex-reversal in 46,XY humans 总被引:6,自引:0,他引:6
J German J L Simpson R S Chaganti R L Summitt L B Reid I R Merkatz 《Science (New York, N.Y.)》1978,202(4363):53-56
Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similiar to those of 45,X women. 相似文献
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Hafezparast M Klocke R Ruhrberg C Marquardt A Ahmad-Annuar A Bowen S Lalli G Witherden AS Hummerich H Nicholson S Morgan PJ Oozageer R Priestley JV Averill S King VR Ball S Peters J Toda T Yamamoto A Hiraoka Y Augustin M Korthaus D Wattler S Wabnitz P Dickneite C Lampel S Boehme F Peraus G Popp A Rudelius M Schlegel J Fuchs H Hrabe de Angelis M Schiavo G Shima DT Russ AP Stumm G Martin JE Fisher EM 《Science (New York, N.Y.)》2003,300(5620):808-812
Degenerative disorders of motor neurons include a range of progressive fatal diseases such as amyotrophic lateral sclerosis (ALS), spinal-bulbar muscular atrophy (SBMA), and spinal muscular atrophy (SMA). Although the causative genetic alterations are known for some cases, the molecular basis of many SMA and SBMA-like syndromes and most ALS cases is unknown. Here we show that missense point mutations in the cytoplasmic dynein heavy chain result in progressive motor neuron degeneration in heterozygous mice, and in homozygotes this is accompanied by the formation of Lewy-like inclusion bodies, thus resembling key features of human pathology. These mutations exclusively perturb neuron-specific functions of dynein. 相似文献
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Arrhenius G Asunmaa S Drever JI Everson J Fitzgerald RW Frazer JZ Fujita H Hanor JS Lal D Liang SS Macdougall D Reid AM Sinkankas J Wilkening L 《Science (New York, N.Y.)》1970,167(3918):659-661
Phase chemistry, structure, and radiation effects were studied in rock, breccia, and soil samples. The regolith apparently developed in the final stages of accretion and was modified by later impact processes and radiation weathering. Exposure ages indicate transfer of buried igneous rock fragments to the near surface late in lunar history. With a few exceptions igneous rock fragments, soil, and breccia share the same distinctive chemistry, probably acquired before accretion of the moon. The igneous rocks texturally resemble basaltic achondrites, and the soil and breccias contain glassy spheres analogous to chondrules. 相似文献
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90.
Structure of a legume lectin with an ordered N-linked carbohydrate in complex with lactose 总被引:13,自引:0,他引:13
The three-dimensional structure of the lactose complex of the Erythrina corallodendron lectin (EcorL), a dimer of N-glycosylated subunits, was determined crystallographically and refined at 2.0 angstrom resolution to an R value of 0.19. The tertiary structure of the subunit is similar to that of other legume lectins, but interference by the bulky N-linked heptasaccharide, which is exceptionally well ordered in the crystal, forces the EcorL dimer into a drastically different quaternary structure. Only the galactose moiety of the lactose ligand resides within the combining site. The galactose moiety is oriented differently from ligands in the mannose-glucose specific legume lectins and is held by hydrophobic interactions with Ala88, Tyr106, Phe131, and Ala218 and by seven hydrogen bonds, four of which are to the conserved Asp89, Asn133, and NH of Gly107. The specificity of legume lectins toward the different C-4 epimers appears to be associated with extensive variations in the outline of the variable parts of the binding sites. 相似文献