Global mapping of the yeast genetic interaction network   总被引：1，自引：0，他引：1  

Tong AH  Lesage G  Bader GD  Ding H  Xu H  Xin X  Young J  Berriz GF  Brost RL  Chang M  Chen Y  Cheng X  Chua G  Friesen H  Goldberg DS  Haynes J  Humphries C  He G  Hussein S  Ke L  Krogan N  Li Z  Levinson JN  Lu H  Ménard P  Munyana C  Parsons AB  Ryan O  Tonikian R  Roberts T  Sdicu AM  Shapiro J  Sheikh B  Suter B  Wong SL  Zhang LV  Zhu H  Burd CG  Munro S  Sander C  Rine J  Greenblatt J  Peter M  Bretscher A  Bell G  Roth FP  Brown GW  Andrews B  Bussey H  Boone C 《Science (New York, N.Y.)》2004,303(5659):808-813

A genetic interaction network containing approximately 1000 genes and approximately 4000 interactions was mapped by crossing mutations in 132 different query genes into a set of approximately 4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and similar patterns of interactions tended to identify components of the same pathway. The genetic network exhibited dense local neighborhoods; therefore, the position of a gene on a partially mapped network is predictive of other genetic interactions. Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms.  相似文献   

Multi-scale processes influencing global carbon storage and land-carbon-climate nexus: A critical review     

Owais Ali WANI  Shamal Shasang KUMAR  Nazir HUSSAIN  Anas Ibni Ali WANI  Subhash BABU  Parvej ALAM  Megna RASHID  Simona Mariana POPESCU  Sheikh MANSOOR 《土壤圈》2023,33(2):250-267

Carbon(C) is a key constitutive element in living organisms(plants, microbes, animals, and humans). Carbon is also a basic component of agriculture because it plays a dynamic role in crop growth, development, nutrient cycling, soil fertility, and other agricultural features. The presence of C enhances soil physical, chemical, and biological properties. The C cycle supports all life on the Earth by transferring C between living organisms and the environment. The global climate is changing, and th...  相似文献   

EFFECTS OF DIFFERENT NITROGEN,PHOSPHORUS, POTASSIUM RATES ON THE QUALITY AND QUANTITY OF CITRUS PLANTS,VARIETY THOMSON NOVEL UNDER RAINFED AND IRRIGATED CONDITIONS     

A. Sheikh Ashkevari  S. H. Hoseinzadeh  M. Miransari 《Journal of plant nutrition》2013,36(9):1412-1423

Plants require nutrients including nitrogen (N), phosphorus (P), and potassium (K) for their growth and production. Although there have been previously extensive research work regarding the effects of NPK on plant growth, data related to the effects of long term application of NPK on the quality and quantity of citrus under rainfed and irrigated conditions are little. Accordingly, such effects were evaluated in this research work using different chemical fertilization factorially combined and on the basis of a completely randomized block design. Using ammonium sulfate (100, 150 and 200 g tree ^{? 1}), triple super phosphate (0, 25, 50, and 75 g tree^?1) and potassium sulfate (0, 50, 100, 150 g tree ^{? 1}) the quantity and quality of citrus fruit, variety Thomson were determined in a 10-year experiment in two different research stations in Ramsar, Iran. NPK fertilization significantly affected the quality and quantity of citrus fruits, indicating the significance of NPK fertilization for citrus production.  相似文献   

Fabrication of poly(caprolactone) nanofibers containing hydroxyapatite nanoparticles and their mineralization in a simulated body fluid     

Muzafar A. Kanjwal  Faheem A. Sheikh  R. Nirmala  Javier Macossay  Hak Yong Kim 《Fibers and Polymers》2011,12(1):50-56

In the present study, we introduce poly(caprolactone) (PCL) nanofibers that contain hydroxyapatite (HAp) nanoparticles (NPs) as a result of an electrospinning process. A simple method that does not depend on additional foreign chemicals has been employed to synthesize HAp NPs through calcination of bovine bones. Typically, a colloidal gel consisting of PCL/HAp has been electrospun to form nanofibers. Physiochemical aspects of prepared nanofibers were characterized for FE-SEM, TEM, XRD and FTIR which confirmed nanofibers were well-oriented and had good dispersion of HAp NPs. Parameters affecting the utilization of the prepared nanofibers in various nano-biotechnological fields have been studied; for instance, the bioactivity of the produced nanofiber mats was investigated while incubated with stimulated body fluid (SBF). The results from incubation of nanofibers in SBF indicate that incorporation of HAp strongly activates precipitation of the apatite-like materials because the HAp NPs act as seeds that accelerate crystallization of the biological HAp from the utilized SBF.  相似文献   

Allelopathic potential of indigenous Bangladeshi rice varieties          下载免费PDF全文

Sheikh M. Masum  Mohammad Amzad Hossain  Hikaru Akamine  Jun‐Ichi Sakagami  Prasanta C. Bhowmik 《Weed Biology and Management》2016,16(3):119-131

A series of experiments was conducted in the laboratory and greenhouse of the Subtropical Field Science Center, University of the Ryukyus, Japan, from April to October 2015 to assess the allelopathic potential of 50 indigenous Bangladeshi rice varieties by using the donor–receiver bioassay, equal compartment agar method (ECAM), plant residue extract method and pot culture method. Lettuce (Lactuca sativa L.), cress (Lepidium sativum L.), radish (Raphanus sativus L.), barnyard grass (Echinochloa crus‐galli L. Beauv.) and jungle rice (Echinochloa colona L.) were used as the test plants. The highest inhibition effect was given by Boterswar, while the stimulating effect was given by Kartikbalam and Panbira in the donor–receiver bioassay and ECAM tests. Boterswar, Goria, Biron and Kartiksail were selected as the highest allelopathic‐potential varieties by the donor–receiver bioassay and ECAM. In the methanol extract test, Boterswar gave the strongest inhibitory effect on both barnyard grass and jungle rice, while Kartiksail gave the highest inhibitory effect on the jungle rice shoot. The growth parameters and total dry matter of barnyard grass in the greenhouse pot experiment were significantly reduced as a result of the application of aqueous extracts of the selected rice varieties, which was similar to the results of the laboratory experiments. The varieties of Boterswar, Goria, Biron and Kartiksail were selected as the most allelopathic among the 50 indigenous Bangladeshi rice varieties. These rice varieties could be used for the isolation and identification of allelochemicals and to further develop new varieties that are tolerant to weeds.  相似文献   

Synthesis and characterization of new copolymers from glycidyl methacrylate and tetrahydrofurfuryl acrylate: Determination of reactivity ratios     

Ahmad Danial Azzahari  Rosiyah Yahya  Aziz Hassan  Md. Rezaul Karim Sheikh 《Fibers and Polymers》2012,13(5):555-563

The new copolymers from different feed compositions of glycidyl methacrylate (GMA) and tetrahydrofurfuryl acrylate (THFA) were synthesized using free radical polymerization in toluene at 70±1 °C using benzoyl peroxide (BPO) as initiator. The polymers were characterized by ¹H NMR, ¹³C NMR and FTIR spectroscopic techniques. The polydispersities of the copolymers suggest a strong tendency for chain termination by disproportionation. The glass transition temperature of the copolymers increases with increase in GMA content. The thermal stability of the copolymers increases with increase in THFA content. The copolymer compositions were determined using ¹H NMR analysis. Reactivity ratios for GMA and THFA as determined by the Mao-Huglin method were r₁=0.379 and r₂=0.266. The results showed that all these copolymerizations are strictly linear systems describable by the Mayo-Lewis equation based on the terminal model and that accurate reactivity ratio data can be obtained.  相似文献   

Ultrasound assisted extraction of natural dyes and natural mordants vis a vis dyeing     

Javed Sheikh  Priyanka S. Jagtap  M. D. Teli 《Fibers and Polymers》2016,17(5):738-743

Most of the natural dyes require mordants for their fixation on textile materials. Natural mordants are thus gaining importance in order to get complete-natural dyeing. In the present work, natural dyes and mordants were extracted using conventional and ultrasound methods and comparative studies were made. The natural mordants namely harda and tamarind seed coat and natural dyes like turmeric, henna were extracted using conventional and ultrasound approaches and various extracts obtained were described in terms of their optical densities. In order to verify the extraction efficiencies, wool fabrics were dyed with extracts of various combinations of mordants/dyes and dyed fabrics were evaluated for their colour strengths and fastness properties. The extent of colour extraction was higher in case of ultrasound assisted extraction as compared to that of conventional method. The fabrics dyed using extracts of ultrasound method showed higher colour values as compared to those dyed using extracts from conventional methods thus confirming ultrasound as more efficient method of extraction.  相似文献   

Ovine and caprine toxoplasmosis (Toxoplasma gondii) in aborted animals in Jordanian goat and sheep flocks     

Abu-Dalbouh MA  Ababneh MM  Giadinis ND  Lafi SQ 《Tropical animal health and production》2012,44(1):49-54

Two hundred and fifty-five biological samples (106 aborted foetal tissue samples and 149 blood samples from aborted sheep and goats) were collected from 188 animals during the lambing season from September 2009 to April 2010 from the Mafraq region of Jordan. The sampled animals belonged to 93 goat and sheep flocks that had cases of abortion. A total of 169 (66.3%) biological samples were collected from sheep and 86 (33.7%) from goats. Seventy-six (29.8%) biological samples (45 blood and 31 tissue samples) were positive for Toxoplasma gondii by PCR assay. The positive samples were obtained from 43 sheep and 23 goats. The overall toxoplasma-specific prevalence rate was 35.1% (66/188). Forty flocks (43%) had at least one T. gondii PCR-positive animal. The risk factors related to flock health status and farm management that are hypothesized to be associated with T. gondii PCR positivity were also assessed using multiple logistic regressions. The presence of cats (OR = 4.74), a large flock size (OR = 2.76) and the method of disposing the aborted foetuses (OR = 3.77) were all statistically significant (P < 0.05) risk factors that were positively associated with toxoplasma positivity in goat and sheep flocks.  相似文献   

Removal of Nickel onto Alkali Treated Rice Bran     

Zafar  Muhammad Nadeem  Abbas  Imran  Nadeem  Raziya  Sheikh  Munir Ahmad  Ghauri  Muhammad Afzal 《Water, air, and soil pollution》2009,197(1-4):361-370

Water, Air, & Soil Pollution - Different bases were used for the pretreatment of Rice bran biomass. Pretreatment with bases such as NaOH, Ca(OH)2 and Al(OH)3 were found to improve biosorption...  相似文献   

Effect of oil impregnation on water repellency,dimensional stability and mold susceptibility of thermally modified European aspen and downy birch wood     

Sheikh Ali Ahmed  Tom Morén  Margot Sehlstedt-Persson  Åsa Blom 《Journal of Wood Science》2017,63(1):74-82

Conventional chemical wood preservatives have been banned or restricted in some applications due to human and animal toxicity and their adverse impact on the surrounding environment. New, low-environmental-impact wood treatments that still provide effective protection systems are needed to protect wood. Thermal modification of wood could reduce hygroscopicity, improve dimensional stability and enhance resistance to mold attack. The aim of this study was to investigate if these properties enhanced in thermally modified (TM) wood through treatments with oils. In this study, TM European aspen (Populus tremula) and downy birch (Betula pubescens) wood were impregnated with three different types of oil: water-miscible commercial Elit Träskydd (Beckers oil with propiconazole and 3-iodo-2-propynyl butylcarbamate, IPBC), a pine tar formulation and 100% tung oil. The properties of oil-impregnated wood investigated were water repellency, dimensional stability and mold susceptibility. The treated wood, especially with pine tar and tung oil, showed an increase in water repellency and dimensional stability. However, Beckers oil which contains biocides like propiconazole and IPBC showed better protection against mold compared with pine tar and tung oil. To enhance the dimensional stability of the wood, pine tar and tung oil can be used, but these oil treatments did not significantly improve mold resistance rather sometimes enhanced the mold growth, whereas a significant anti-mold effect was observed on Beckers oil treated samples.  相似文献