Descending efferents from the superior colliculus relay integrated multisensory information   总被引：3，自引：0，他引：3  

M A Meredith  B E Stein 《Science (New York, N.Y.)》1985,227(4687):657-659

By means of their efferent projections to motor and premotor structures, the cells in the deep superior colliculus are intimately involved in behaviors that control the orientation of the eyes, pinnae, and head. These same efferent cells receive multiple sensory inputs, thereby apparently enabling an animal to orient its receptor organs in response to a wide variety of cues. This sensory convergence also provides a system in which motor responses need not be immutably linked to individual stimuli but can vary in reaction to the multitude of stimuli present in the environment at any given moment.  相似文献   

Possible etiology of schizophrenia: progressive damage to the noradrenergic reward system by 6-hydroxydopamine   总被引：6，自引：0，他引：6  

L Stein  C D Wise 《Science (New York, N.Y.)》1971,171(975):1032-1036

Single or repeated intraventricular injections of 6-hydroxydopamine caused marked and long-lasting deficits in brain self-stimulation and other rewarded behaviors in the rat. The behavioral deficits, as well as the depletion of brain norepinephrine induced by 6-hydroxydopamine, were prevented by prior treatment with chlorpromazine. Episodic or continuous formation of endogenous 6-hydroxydopamine in man as a result of a genetically determined enzymatic error could selectively damage the binding capacity and, eventually, the structural integrity of the noradrenergic reward mechanism. Such damage might cause the fundamental symptoms and long-term downhill course of schizophrenia.  相似文献   

Deep earthquakes: a fault too big?   总被引：1，自引：0，他引：1  

Stein S 《Science (New York, N.Y.)》1995,268(5207):49-50

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DNA hybridization and evolutionary relationships in three osmunda species     

Stein DB  Thompson WF 《Science (New York, N.Y.)》1975,189(4206):888-890

Molecular hybridization techniques have been used to estimate the degree of DNA base sequence homology between some members of the fern genus Osmunda. Under conditions permitting extensive reassociation, measurements of the extent of inter-specific reaction and the thermal stability of the hybrid molecules indicated that O. claytoniana L. (interrupted fern) shares more DNA homology with O. cinnamomea L. (cinnamon fern) than it does with O. regalis L. (royal fern). These findings are in conflict with predictions from a recent analysis of living and fossil specimens by numerical techniques. However, they are consistent with the earlier, more traditional, taxonomic assignments.  相似文献   

Pemoline and magnesium hydroxide: lack of effect on RNA and protein synthesis     

H H Stein  T O Yellin 《Science (New York, N.Y.)》1967,157(784):96-97

Brain RNA polymerase isolated from rats treated with pemoline and magnesium hydroxide (Cylert) was not more active than enzyme from control animals. The drug did not increase enzymic activity in vitro. Pemoline did not significantly affect either RNA or protein synthesis in suspensions of Ehrlich ascites carcinoma cells.  相似文献   

Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis     

Spruck CH  de Miguel MP  Smith AP  Ryan A  Stein P  Schultz RM  Lincoln AJ  Donovan PJ  Reed SI 《Science (New York, N.Y.)》2003,300(5619):647-650

We generated mice lacking Cks2, one of two mammalian homologs of the yeast Cdk1-binding proteins, Suc1 and Cks1, and found them to be viable but sterile in both sexes. Sterility is due to failure of both male and female germ cells to progress past the first meiotic metaphase. The chromosomal events up through the end of prophase I are normal in both CKS2-/- males and females, suggesting that the phenotype is due directly to failure to enter anaphase and not a consequence of a checkpoint-mediated metaphase I arrest.  相似文献   

Aerodynamics of the long pterosaur wing     

Stein RS 《Science (New York, N.Y.)》1976,191(4230):899-899

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Interanimal "memory" transfer: results from brain and liver homogenates     

B Frank  D G Stein  J Rosen 《Science (New York, N.Y.)》1970,169(943):399-402

Sixty mice received either shock or no shock in a shuttle box, or nonspecific stress in another apparatus. Brain and liver homogenates from these animals were then injected into 120 naive recipients, who were all tested in the shuttle box. Subjects receiving brain or liver from shocked or stressed donors had significantly higher latencies than control counterparts. These results are interpreted in terms of stress, rather than a memory transfer hypothesis.  相似文献   

Academic research in Germany: a new support program     

Stein BR 《Science (New York, N.Y.)》1969,165(3898):1096-1100

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Permselective Membranes: Spectroscopic and Conductivity Effects     

Stein G  Forgacs C 《Science (New York, N.Y.)》1963,142(3594):953-954

The absorption spectrum of permselective ion-exchange membranes containing positively charged groups shows specific effects which depend on the nature of the negative gegenion used. Such colored permselective membranes with positive or negative functional groups show increased condutivity after illumination with light flashes. The increased conductivity returns slowly to the original value.  相似文献