Periparturient hemorrhage in mares: 73 cases (1998-2005)     

Arnold CE  Payne M  Thompson JA  Slovis NM  Bain FT 《Journal of the American Veterinary Medical Association》2008,232(9):1345-1351

OBJECTIVE: To determine signalment, physical examination and clinicopathologic abnormalities, outcome, and subsequent fertility of mares with periparturient hemorrhage (PPH) and identify factors associated with outcome (ie, survival vs death). DESIGN: Retrospective case series. ANIMALS: 73 mares. PROCEDURES: Medical records were reviewed for information on age, breed, initial complaint, physical examination and clinicopathologic abnormalities, treatment, outcome, and subsequent fertility. RESULTS: Median age was 14.0 years (range, 5 to 24 years), and median number of foals produced prior to the diagnosis of PPH was 8 (range, 1 to 16). Ten (14%) mares had prepartum hemorrhage and 63 (86%) had postpartum hemorrhage. Treatment was aimed at restoring cardiovascular volume, enhancing coagulation, controlling pain, and reducing the effects of endotoxemia. Sixty-one (84%) mares survived and 12 (16%) died or were euthanized. Common complications included fever, leukopenia, retained fetal membranes, increased digital pulses, thrombophlebitis, and cardiac arrhythmias. Of the 53 surviving mares for which subsequent breeding information was available, 26 (49%) produced 1 or more foals after recovering from PPH. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that PPH can develop in mares of any age and parity. Treatment was associated with a good prognosis for survival and a reasonable prognosis for future fertility.  相似文献   

A possible new inherited myopathy in a young Labrador retriever     

Cosford KL  Taylor SM  Thompson L  Shelton GD 《The Canadian veterinary journal. La revue veterinaire canadienne》2008,49(4):393-397

A 5-month-old, male, Labrador retriever was evaluated for progressive weakness and muscle atrophy. Histologic evaluation of fresh frozen muscle revealed distinct cytoarchitectural changes and central mitochondrial accumulations indistinguishable from those found in the inherited myopathy described in Great Danes. Multiple male littermates and half-siblings were similarly affected.  相似文献   

Baylisascaris procyonis encephalitis in Patagonian conures (Cyanoliseus patagonus), crested screamers (Chauna torquata), and a western Canadian porcupine (Erethizon dorsatum epixanthus) in a Manitoba zoo     

Amy B. Thompson  Gordon J. Glover  Rosemary C. Postey  Jennifer L. Sexsmith  Thomas W.S. Hutchison  Kevin R. Kazacos 《The Canadian veterinary journal. La revue veterinaire canadienne》2008,49(9):885-888

Neurological disease occurred in 4 Patagonian conures (Cyanoliseus patagonus), 2 crested screamer chicks (Chauna torquata), and 1 western Canadian porcupine (Erethizon dorsatum epixanthus) at a Manitoba zoo. Baylisascaris procyonis, the common raccoon roundworm, not previously identified in Manitoba, is considered the likely cause of neural larval migrans in these cases.  相似文献   

National study of the gastrointestinal parasites of dogs and cats in Australia   总被引：1，自引：1，他引：0  

Palmer CS  Thompson RC  Traub RJ  Rees R  Robertson ID 《Veterinary parasitology》2008,151(2-4):181-190

The prevalence of gastrointestinal parasites in Australian pet dogs and cats was largely unknown prior to this study. Current recommendations for the prophylactic treatment of parasites in Australia are based on studies conducted 20-30 years ago. A total of 1400 canine and 1063 feline faecal samples were collected from veterinary clinics and refuges from across Australia. The overall prevalence of gastrointestinal parasites in dogs and cats was 23.9% (CI 21.7-26.1) and 18.4% (CI 16.1-20.7), respectively. Overall Giardia was the most prevalent parasite in dogs (9.3% CI 7.8-10.8) followed by hookworm (6.7% CI 5.4-8.0). Isospora felis was the most prevalent parasite in cats (5.6% CI 4.2-7.0), followed by Toxocara cati (3.2% CI 2.1-4.3). In conclusion the prevalence of intestinal helminths in Australian pet dogs and cats is low. Consequently, consideration should be given to the future use of anthelmintics and continued emphasis on pet owner education as means of preventing infection.  相似文献   

Hyperleptinemia in Mares: Prevalence in Lactating Mares and Effect on Rebreeding Success     

N.K. Huff  D.L. Thompson Jr.L.R. Gentry  C.G. Depew 《Journal of Equine Veterinary Science》2008

Previous research from our laboratory showed that approximately one third of obese, nonfoaling mares displayed a condition of hyperleptinemia coupled with hyperinsulinemia that resembled type 2 diabetes in humans. The current study was performed to evaluate the prevalence of the hyperleptinemic syndrome in lactating mares and its possible impact on their rebreeding success. Additionally, we investigated possible relationships between leptin levels in lactating versus nonlactating mares. In experiment 1, jugular blood samples were collected from 198 lactating mares on two occasions approximately 2 weeks apart. The mares resided on eight farms in Louisiana; breeds included Thoroughbred (n = 86), Quarter Horse (n = 71), Warmblood (n = 24), and draft-type (n = 17). Body condition scores (BCS) were measured at the time of blood sampling; plasma samples were assessed for leptin and progesterone concentrations. Reproductive and medical histories, as well as feeding regimens, were compiled on each mare. Based on our previous reports and examination of the current data, a mare was considered hyperleptinemic if her plasma samples contained greater than10 ng/mL leptin; normal was considered 6.0 ng/mL or less; mares with levels above 6.0 and 10 ng/mL or greater were classified as intermediate. Overall mean leptin concentration was 4.7 ng/mL, and average BCS was 5.5. After analysis, 24 mares were classified as hyperleptinemic (12%), 138 were classified as normal (70%), and 36 were classified as intermediate (18%). Leptin concentrations were affected by BCS (P = .08), with higher concentrations in mares with higher body condition; however, there were hyperleptinemic mares with BCS of 4 to 5.5. Feeding regimen affected leptin concentrations (P < .01), with mares on pasture full-time having the highest concentrations. There was no effect of breed, mare age, number of years the mare had been bred, number of live foals, progesterone concentrations, or last foaling date on leptin concentrations. Rebreeding success averaged 81% overall and was not affected by leptin classification. In experiment 2, nonfoaling mares kept on pasture had mean leptin concentrations of 7.0 ng/mL; 8 of 31 mares (26%) displayed hyperleptinemia. Mean leptin concentration was correlated with BCS (R² = 0.65; P < .02) but was not affected by age of the mare. It was concluded that the hyperleptinemic condition occurs in lactating broodmares, even at BCS as low as 4. The overall incidence appears to be lower in broodmares than in nonfoaling mares, likely because of their lower BCS in general and the energy demands of lactation. Hyperleptinemia did not affect rebreeding success at the end of the breeding season.  相似文献   

Effects of intravenous and topical laryngeal lidocaine on heart rate,mean arterial pressure and cough response to endotracheal intubation in dogs          下载免费PDF全文

Kate R Thompson  Eva Rioja 《Veterinary anaesthesia and analgesia》2016,43(4):371-378

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Desert island papers—A life in variance parameter and quantitative genetic parameter estimation reviewed using 16 papers     

Robin Thompson 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2019,136(4):230-242

I review my scientific career in terms of eight areas and 16 papers. The first two areas are associated with childhood. The other six are associated with residual maximum likelihood (REML), canonical transformation, inbreeding in selected populations, average information residual maximum likelihood (AIREML), the computer program ASReml and sampling‐based estimation.  相似文献   

Ketoprofen pharmacokinetics of R‐ and S‐isomers in juvenile loggerhead sea turtles (Caretta caretta) after single intravenous and single‐ and multidose intramuscular administration          下载免费PDF全文

K. A. Thompson  M. G. Papich  B. Higgins  J. Flanagan  E. F. Christiansen  C. A. Harms 《Journal of veterinary pharmacology and therapeutics》2018,41(2):340-348

Ketoprofen is a nonsteroidal anti‐inflammatory and analgesic agent that nonselectively inhibits cyclooxygenase, with both COX‐1 and COX‐2 inhibition. Recent studies on COX receptor expression in reptiles suggest that nonselective COX inhibitors may be more appropriate than more selective inhibitors in some reptiles, but few pharmacokinetic studies are available. The goal of this study was to determine single‐ and multidose (three consecutive days) pharmacokinetics of racemic ketoprofen administered intravenously and intramuscularly at 2 mg/kg in healthy juvenile loggerhead turtles (Caretta caretta). The S‐isomer is the predominant isomer in loggerhead sea turtles, similar to most mammals, despite administration of a 50:50 racemic mixture. Multidose ketoprofen administration demonstrated no bioaccumulation; therefore, once‐daily dosing will not require dose adjustment over time. S‐isomer pharmacokinetic parameters determined in this study were C_max of 10.1 μg/ml by IM injection, C₀ of 13.4 μg/ml by IV injection, AUC of 44.7 or 69.4 μg*hr/ml by IM or IV injection, respectively, and T½ of 2.8 or 3.6 hr by IM or IV injection, respectively. Total ketoprofen plasma concentrations were maintained for at least 12 hr above concentrations determined to be effective for rats and humans. A dose of 2 mg/kg either IM or IV every 24 hr is likely appropriate for loggerhead turtles.  相似文献   

Letters to the editor          下载免费PDF全文

Thompson AR 《The Canadian veterinary journal. La revue veterinaire canadienne》1988,29(4):327-327

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Investigation of bovine haemoplasmas and their association with anaemia in New Zealand cattle     

AMJ McFadden  HJ Ha  JJ Donald  IM Bueno  M van Andel  JC Thompson 《New Zealand veterinary journal》2016,64(1):65-68

CASE HISTORY AND CLINICAL FINDINGS: A dairy cow, from a herd in the Waikato region of New Zealand, was reported with regenerative anaemia on 12 September 2014. Testing of blood from the animal using PCR assays for Theileria orientalis produced a negative result for both Chitose and Ikeda types.

LABORATORY FINDINGS: Using PCR and DNA sequencing, blood from the cow was positive for Candidatus Mycoplasma haemobos. Further testing of another 12 animals from the case herd, 27 days after the affected cow was first reported, showed 11 animals were positive for Candidatus M. haemobos or Mycoplasma wenyonii in the PCR. None of these cattle were clinically anaemic or positive for T. orientalis Ikeda type using PCR.

A convenience sample of 47 blood samples from cattle throughout New Zealand, submitted to the Investigation and Diagnostic Centre (Ministry for Primary Industries) for surveillance testing for T. orientalis Ikeda, was selected for further testing for bovine haemoplasmas. Of these samples, 6/47 (13%) and 13/47(28%) were positive for M. wenyonii and Candidatus M. haemobos, respectively. There was no difference in the proportion of samples positive for the bovine haemaplasmas between cattle with anaemia that were negative for T. orientalis (6/20, 33%), or without anaemia or T. orientalis (10/18, 56%), or from cattle herds experiencing anaemia and infection with T. orientalis Ikeda type (3/9, 33%).

DIAGNOSIS: Bovine haemoplasmosis.

CLINICAL RELEVANCE: The presence of bovine haemoplasmas in blood does not establish causality for anaemia in cattle. Diagnosis of anaemia associated with haemoplasmosis would require exclusion of other causes of regenerative anaemia and an association of the agent with anaemia in affected cattle herds. The data collected in this study did not provide evidence that bovine haemoplasmas were associated with a large number of outbreaks of anaemia in cattle in New Zealand.  相似文献