Additive effects of tetrocarcin-A and diminazene aceturate concurrently administered against Babesia rodhaini-inoculated mice     

K Namikawa  Y Sakuma  F Sunaga  Y Kanno 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1988,50(4):968-970

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Experimental studies on body temperature rhythm in dogs. I. Application of cosinor method to body temperature rhythm in dogs (author's transl)     

Y Kanno 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1977,39(1):69-76

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Hexachlorophene and cuprizone induce the spongy change of the developing rat brain by different mechanisms: the role of 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNPase)     

Kanno T  Sasaki S  Yamada N  Kawasako K  Tsuchitani M 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2012,74(7):837-843

The goal of this research was to identify mechanisms responsible for the spongy change induced in rats after repeated hexachlorophene (HCP) or cuprizone (CPZ) dosing. Rats were dosed with 35 mg/kg HCP for 5 days followed by drug withdrawal for 7 days suffered spongy changes to the white matter of the cerebrum, cerebellum, medulla oblongata, and spinal cord that were accompanied by degeneration of oligodendroglia. The severity of both lesions increased prominently on day 5; however, the spongy change decreased and degeneration of oligodendroglia reversed on day 12 (7 days after dosing ceased). On day 12, cerebral cortex oligodendroglia were stained strongly by anti-CNPase. Other rats were fed for 8 days with powdered chow containing 1% (w/w) CPZ, which was then withdrawn for 16 days. The rats exhibited the spongy change in the white matter of the cerebrum and cerebellum as well as oligodendroglial cell death from day 3. The severity of both lesions increased prominently on day 8. Cerebral cortex oligodendroglia were stained strongly by anti-CNPase on days 3 to 8 and decreased to the control levels by day 24 (16 days after dosing ceased). Electron microscopy revealed that oligodendroglia frequently displayed apoptotic morphology. These findings suggest that CNPase expression was induced in the course of restoration following HCP-induced insults to oligodendroglia and the myelin sheath, and in the course of demyelination by CPZ-induced damage to oligodendroglia. However, the role of CNPase on both courses is unclear.  相似文献   

Plasma adrenomedullin concentration in dogs with myxomatous mitral valvular disease     

Kanno N  Asano K  Teshima K  Seki M  Edamura K  Uechi M  Tanaka S 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2012,74(6):739-743

Adrenomedullin (AM), a peptide identified to have vasodilating and natriuretic effects, is involved in the regulation of the cardiovascular system. To evaluate plasma AM concentration in dogs with myxomatous mitral valvular disease (MMVD), and to investigate the associations between the concentrations of plasma AM and natriuretic peptides and the echocardiographic data, we evaluated plasma AM concentrations in 31 healthy control dogs and 57 dogs with MMVD. Plasma AM concentrations in dogs with MMVD were higher than that in the control subjects. The plasma AM concentration increased in conjunction with the severity of heart failure according to the International Small Animal Cardiac Health Council (ISACHC). The AM concentrations were 25.1 ± 5.0 fmol/ml (ISACHC class Ia), 29.9 ± 11.0 fmol/ml (ISACHC class Ib), 43.4 ± 19.8 fmol/ml (ISACHC class II) and 73.5 ± 21.7 fmol/ml (ISACHC class III) and 7.5 ± 5.1 fmol/ml (control group), respectively. The receiver operating characteristic curve indicated an area of 0.93 (95% CI, 0.8801-0.9889; <0.0001), a cutoff value of 30.5 fmol/ml, a sensitivity of 87.1%, and a specificity of 82.5% for the determination of congestive heart failure. Plasma AM concentrations correlated with atrial natriuretic peptide concentrations, LA/Ao ratio, and left ventricular diameter. In conclusion, AM may be a potential diagnostic marker for canine MMVD and possibly plays a pathophysiological role in collaboration with the other neurohumoral factors such as natriuretic peptides.  相似文献   

Low-fidelity homing behaviour of Biwa salmon <Emphasis Type="Italic">Oncorhynchus</Emphasis> sp. landlocked in Lake Biwa as inferred from otolith elemental and Sr isotopic compositions     

Yosuke Amano  Masayuki Kuwahara  Toshiro Takahashi  Kotaro Shirai  Kodai Yamane  Tatsuya Kawakami  Kazuki Yokouchi  Hiroshi Amakawa  Tsuguo Otake 《Fisheries Science》2018,84(5):799-813

Biwa salmon Oncorhynchus sp. is endemic to Lake Biwa, Japan, where it is an important commercial and recreational fisheries species. However, no information is currently available on its population structure and migration ecology. Therefore, here we evaluated whether otolith Sr/Ca, Ba/Ca and ⁸⁷Sr/⁸⁶Sr ratios can be used as natural signatures in Biwa salmon and then used these to determine the natal origins of lake-migration-phase individuals and spawning adults, and the homing ability of spawning adults in the Lake Biwa water system. Quadratic discriminant function analysis demonstrated that the lake-migration school comprised individuals with multiple origins, including rivers to the east, west and north of Lake Biwa, and that the homing rate of spawning adults was low (18 out of 80 individuals), with ca. 78% of fish straying into non-natal rivers. However, this straying behaviour was not spatially random, with fish tending to migrate upstream in rivers neighbouring their natal rivers. The high rate of straying in spawning adults is considered important for establishing and maintaining this species, which is highly adapted to life in the Lake Biwa water system where environmental disturbances often occur.  相似文献   

Sr isotopic compositions of ayu otolith and its ambient water     

Hiroshi Amakawa  Takafumi Suzuki  Toshiro Takahashi  Yoshiyuki Tatsumi  Tsuguo Otake 《Fisheries Science》2012,78(5):1023-1029

Sr isotopic compositions of ayu otolith and water collected from Japanese rivers were measured to validate the relationship between otolith and ambient water for this species. Micromilling and rostrum-cut methods employed for otolith sampling were compared and yielded almost indistinguishable otolith Sr isotopic composition data. A good correlation observed between data on otolith and those on ambient water (river water and sea water) confirms the usefulness of Sr isotopic composition for elucidating migratory behavior of ayu, as already verified in other species.  相似文献   

Serum hyaluronic acid in dogs with congenital portosystemic shunts     

M. Seki  K. Asano  M. Sakai  N. Kanno  K. Teshima  K. Edamura  S. Tanaka 《The Journal of small animal practice》2010,51(5):260-263

Objectives : To compare the serum level of hyaluronic acid in dogs with congenital portosystemic shunt with that in healthy dogs and to investigate the perioperative change in serum hyaluronic acid following shunt attenuation. Methods : Blood samples were obtained from 29 congenital portosystemic shunt dogs before the operation, and 2 and 4 weeks after the operation from 17 and 7 dogs, respectively. The serum hyaluronic acid level of these dogs was measured and compared with that of 10 healthy beagles. Results : The median preoperative hyaluronic acid level in dogs with congenital portosystemic shunt was significantly elevated compared with that in healthy dogs. Furthermore, the median postoperative hyaluronic acid level significantly decreased compared with the median preoperative levels in congenital portosystemic shunt dogs. Clinical Significance : In the case of dogs with congenital portosystemic shunt, the reduction of intrahepatic portal blood flow might lower the clearance rate of hyaluronic acid in hepatic sinusoidal endothelial cells, so hyaluronic acid clearance could be improved by attenuation of a shunt vessel. Hence, serum hyaluronic acid levels might be useful to evaluate liver function and also have the potential to evaluate successful attenuation of a shunt vessel in dogs with congenital portosystemic shunt. Further investigations are required to clarify whether serum hyaluronic acid offers significant benefits over existing markers such as serum bile acid or ammonia concentrations.  相似文献   

On the nature of fresh volcanic ashes as parent material ejected from the Sakurajima and Aso volcanoes     

Ichiro Kanno  Masao Nagai  Shizuoki Arimura 《Soil Science and Plant Nutrition》2013,59(1):77-80

There are few pedological studies in Japan of fresh volcanic ash. Fundamental information of the material from which Japanese volcanic-ash soils have developed, is of importance to obtain a better understanding of pedogenesis of such soils. The present paper deals with the mechanical. mmeralogical, and chemical characteristics of fresh ash ejected from the Sakurajima and Aso volcanoes which are among the most active in Japan.  相似文献   

Characteristics and classification of an unirrigated anthropogenic-alluvial soil found in the Kumamoto Plain     

Ichiro Kanno  Yoshio Honjo  Shizuoki Arimura  Yukio Kuwano 《Soil Science and Plant Nutrition》2013,59(1):14-23

In Japan anthropogenic-alluvial soils excluding irrigated rice soils are lagging for behind other genetic soil types in pedological investigations. Although there are some investigations of anthropogenic-alluvial soils used for mulberry plantations, orchards, vegetable gardens, and seeding beds for trees, the main object of these investigations is not pedological. Kanno et al. (1) reported that unirrigated anthropogenic-alluvial soils used for vegetable growing in the Chikugo Plain resemble the “Alochthonous brown warp soil” defined by Kubiena (2). First of all, it is of great importance to accumulate general data for unirrigated anthropogenic-alluvial soils and to develop the classification principles for them. Classification problems will be settled in accordance with the accumulated data. This paper deals with characteristics of an unirrigated anthorpogenic-alluvial soil found in the Kumamoto Plain and with classification principles for it. These principles have almost never been described for a pedological standpoint in Japan.  相似文献   

Genesis and characteristics of brown forest soils derived from Serpentine in Kyushu,Japan     

Ichiro Kanno  Yutaka Onikura  Shizuoki Arimura  Shoichi Tokudome 《Soil Science and Plant Nutrition》2013,59(3):6-15

One of the main objects of the present study is to determine what genetic soil types have been formed from ultra-basic rocks such as serpentine under humid, subtropical conditions. Red-Yellow soils, which are important zonal soils in Kyushu, have not been formed from serpentine, but Brown Forest soils have been formed, as will be described in the part 2 of this paper. This fact for the most part has been governed by the mineralogical and chemical peculiarities of serpentine. Therefore the part 1 of this paper deals with the mineralogical and chemical characteristics of serpentine as a parent rock from which Brown Forest soils have developed.  相似文献