What is your diagnosis? Blood smear from a horse          下载免费PDF全文

Katie M. Boes  Nicole M. Weinstein 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2017,46(3):542-543

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In vitro assay of nuclear uptake of doxorubicin hydrochloride in osteosarcoma cells of dogs.     

M J Weinstein  J Berg  K Kusuzaki  D S Springfield  M C Gebhardt  H J Mankin 《American journal of veterinary research》1991,52(12):1951-1955

A rapid, simple chemosensitivity assay, assessing tumor cell nuclear uptake of doxorubicin hydrochloride, was evaluated in 16 dogs with appendicular osteosarcoma. Doxorubicin was administered to dogs in 5 biweekly treatments, and surgical resection was performed after the second or third treatment. The chemosensitivity assay was performed on biopsy specimens from all dogs before chemotherapy. It was repeated on tissue from resected tumors, and tumors were evaluated histologically to determine the degree of necrosis resulting from chemotherapy. Disease-free and total survival time correlated significantly (P less than 0.05 in both cases) with the degree of postchemotherapy necrosis of the primary tumors. Significant correlation was not apparent between the percentage of tumor cells with nuclear uptake of doxorubicin (in either biopsy or resection samples) and disease-free or total survival time. The percentage of cells with nuclear uptake of doxorubicin in surgically resected tumors correlated significantly (P less than 0.05) with percentage of necrosis.  相似文献   

Nonangiogenic and nonlymphomatous sarcomas of the canine spleen: 57 cases (1975-1987)     

M J Weinstein  J L Carpenter  C J Schunk 《Journal of the American Veterinary Medical Association》1989,195(6):784-788

The case records of and histopathologic findings in 57 dogs with nonangiogenic and nonlymphomatous splenic sarcomas were reviewed. Splenic neoplasms in these dogs included leiomyosarcoma, fibrosarcoma, undifferentiated sarcoma, liposarcoma, osteosarcoma, chondrosarcoma, myxosarcoma, rhabdomyosarcoma, and fibrous histiocytoma. The clinical signs associated with splenic sarcoma included anorexia or decreased appetite, abdominal distention, polydipsia, lethargy, vomiting, weight loss, and weakness. An abdominal mass was detected in 86% of the dogs by use of abdominal palpation (63%), and/or abdominal radiography (74%). The diagnosis was based on histopathologic findings in the spleen. Abdominal exploratory surgery was performed on 43 of the 57 dogs. Twenty-seven dogs were treated by splenectomy, and 16 were euthanatized at the time of surgery because of widespread metastatic lesions. Of the 14 dogs on which surgery was not performed, 11 were euthanatized on the basis of results of preoperative diagnostic tests, and the remaining 3 dogs had splenic neoplasms that were incidental findings at necropsy. Of the 27 surgically treated dogs, 5 died in the immediate postoperative period, 12 died or were euthanatized within 1 year after splenectomy, and only 5 dogs survived greater than or equal to 1 year. Three dogs were lost to follow-up evaluation, and 2 were still alive 6 and 7 months after surgery. The median survival time of the 22 dogs for which survival was known was 2.5 months. The median survival time for 11 dogs with no obvious metastasis at the time of splenectomy was 9 months.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

L'Accademia nazioniale dei lincei     

Weinstein A 《Science (New York, N.Y.)》1967,156(3779):1178

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Outcome following treatment of feline gastrointestinal mast cell tumours          下载免费PDF全文

L. E. Barrett  K. Skorupski  D. C. Brown  N. Weinstein  C. Clifford  A. Szivek  S. Haney  S. Kraiza  E. L. Krick 《Veterinary and comparative oncology》2018,16(2):188-193

Prognosis of feline gastrointestinal mast cell tumours (FGIMCT), based on limited available literature, is described as guarded to poor, which may influence treatment recommendations and patient outcome. The purpose of this study is to describe the clinical findings, treatment response, and outcome of FGIMCT. Medical records of 31 cats diagnosed with and treated for FGIMCT were retrospectively reviewed. Data collected included signalment, method of diagnosis, tumour location (including metastatic sites), treatment type, cause of death and survival time. Mean age was 12.9 y. Diagnosis was made via cytology (n = 15), histopathology (n = 13) or both (n = 3). Metastatic sites included abdominal lymph node (n = 10), abdominal viscera (n = 4) and both (n = 2). Therapeutic approaches included chemotherapy alone (n = 15), surgery and chemotherapy (n = 7), glucocorticoid only (n = 6) and surgery and glucocorticoid (n = 3). Lomustine (n = 15) and chlorambucil (n = 12) were the most commonly used chemotherapy drugs. Overall median survival time was 531 d (95% confidence interval 334, 982). Gastrointestinal location, diagnosis of additional cancers, and treatment type did not significantly affect survival time. Cause of death was tumour‐related or unknown (n = 12) and unrelated (n = 8) in the 20 cats dead at the time of analysis. The prognosis for cats with FGIMCT may be better than previously reported, with 26% of cats deceased from an unrelated cause. Surgical and medical treatments (including prednisolone alone) were both associated with prolonged survival times. Treatment other than prednisolone may not be necessary in some cats. Continued research into prognostic factors and most effective treatment strategies are needed.  相似文献   

What is your diagnosis? Middle ear material from a dog          下载免费PDF全文

Nicole M. Weinstein  Katie M. Boes  Elizabeth Mauldin  John Rossmeisl 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2016,45(1):195-196

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Long-Term Nitrate Export Pattern from Hubbard Brook Watershed 6 Driven by Climatic Variation     

Bongghi Hong  Dennis P. Swaney  Peter B. Woodbury  David A. Weinstein 《Water, air, and soil pollution》2005,160(1-4):293-326

From 1964 through 1994, the pattern of nitrate (NO₃ ^?) export from Watershed 6 at Hubbard Brook Experimental Forest (HBEF) in New Hampshire, U.S.A., exhibited 10 years of high export (1968–1977) followed by 12 years of low export (1978–1989), with four ‘spikes’ in 1970, 1973, 1976, and 1990. Disruptions of N cycling by soil freezing, insect defoliation, or drought have been suggested to explain this pattern. We developed a model of nitrogen dynamics demonstrating that most of the long-term pattern can be reproduced without explicit consideration of these events. Comparisons of simulated N fluxes between high and low export years suggested that inorganic N input to the soil, from both atmospheric N deposition and N mineralization, was significantly higher during periods of high streamflow NO₃ ^? flux than in low periods. Simulated inorganic N pools (ammonium and nitrate) and fluxes (nitrification, plant uptake, denitrification, and ammonia volatilization) were also significantly higher in these periods. By swapping the time sequences of inorganic N input between high and low export years, it was shown that N mineralization, not atmospheric N deposition, drives the simulated long-term pattern. Although simulated nitrification showed a stronger relationship with measured streamflow NO₃ ^? flux than did N mineralization, nitrification rate depended upon availability of soil ammonium supplied from N mineralization. Because N mineralization in the model varies only with soil temperature and moisture, we conclude that shifts in the interaction of these two variables over time produced the shifts in NO₃ ^? stream exports.  相似文献   

Response     

Perera FP  Rall DP  Weinstein IB 《Science (New York, N.Y.)》1991,252(5008):975-904

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Urine cortisol-creatinine and protein-creatinine ratios in urine samples from healthy dogs collected at home and in hospital     

Lindsey E. Citron  Nicole M. Weinstein  Meryl P. Littman  Jonathan D. Foster 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2020,34(2):777-782

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Mitochondrial DNA is a major cellular target for a dihydrodiol-epoxide derivative of benzo[a]pyrene   总被引：19，自引：0，他引：19  

J M Backer  I B Weinstein 《Science (New York, N.Y.)》1980,209(4453):297-299

When mammalian cell cultures are exposed for 2 hours to (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, a mutagenic and carcinogenic derivative of benzo[a]pyrene, the extent of covalent modificationof mitochondrial DNA is 40 to 90 times greater than that of nuclear DNA. Evidence is presented that this reflects the lipophilic character of the derivative and the very high ratio of lipid to DNA in mitochondria. These results suggest that mitochondrial DNA may be an important cellular target of chemical carcinogens.  相似文献