Decorin concentrations in canine normal and neoplastic mammary gland tissues     

Marek Szczubiał  Marta Kankofer  Jacek Wawrzykowski  Roman Dąbrowski  Wojciech Łopuszyński  Mariola Bochniarz  Piotr Brodzki 《Reproduction in domestic animals》2020,55(10):1404-1410

In the present study, the concentration of decorin in canine normal and neoplastic mammary gland tissues was examined to understand the potential role of decorin in development and progression of canine mammary tumours. The homogenates of 48 mammary gland tumours (10 benign and 38 malignant) and 10 samples of normal canine mammary gland tissue were used in the study. The presence and quantification of decorin was examined in the homogenates using Western blot and specific canine ELISA. Western blotting confirmed the presence of decorin both in the normal mammary gland tissues and in the mammary gland tumours. The concentration of decorin was significantly higher (p < .05) in the benign tumours and non-metastatic malignant tumours than in the normal mammary gland. The concentration of decorin was significantly lower (p < .05) in the malignant tumours with metastasis to regional lymph nodes compared with benign tumours and non-metastatic malignant tumours. No significant differences were found in the level of decorin between the benign and the non-metastatic malignant tumours. Both the histological type of malignant tumours and the histological grade did not significantly affect the concentration of decorin. These findings suggest that neoplastic transformation in the canine mammary gland leads to increase in the decorin protein synthesis. The reducing decorin concentration in canine malignant mammary tumours appears to facilitate the metastatic spread of these tumours.  相似文献   

How geographic and climatic factors affect the adaptation of Douglas-fir provenances to the temperate continental climate zone in Europe     

Niemczyk  Marzena  Chmura  Daniel J.  Socha  Jarosław  Wojda  Tomasz  Mroczek  Piotr  Gil  Wojciech  Thomas  Barb R. 《European Journal of Forest Research》2021,140(6):1341-1361

European Journal of Forest Research - The contribution of Douglas-fir (Df) to European forests is likely to increase as the species is a potential adaptation option to climate change. In this...  相似文献