Low sensitivity of a test for anti‐Mullerian hormone to assess presence of ovaries in prepubertal bitches          下载免费PDF全文

JR Hill  J Wilkinson  J Mallyon  ST Anderson 《Australian veterinary journal》2018,96(9):356-359

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Cyclooxygenases 1 and 2 inhibition and analgesic efficacy of dipyrone at different doses or meloxicam in cats after ovariohysterectomy     

Marco AA. Pereira  Karina D. Campos  Lucas A. Gonçalves  Rosana ST. dos Santos  Patrícia B. Flôr  Aline M. Ambrósio  Denise A. Otsuki  Júlia M. Matera  Cristina OMS. Gomes  Denise T. Fantoni 《Veterinary anaesthesia and analgesia》2021,48(1):7-16

ObjectiveTo evaluate the cyclooxygenases (COX) inhibition, adverse effects and analgesic efficacy of dipyrone or meloxicam in cats undergoing elective ovariohysterectomy.Study designProspective, blinded, randomized, clinical study.AnimalsA total of 30 healthy young cats.MethodsThe cats were randomly assigned to three postoperative groups: D25 (dipyrone 25 mg kg^?1 every 24 hours), D12.5 (dipyrone 12.5 mg kg^?1 every 12 hours) and M (meloxicam 0.1 mg kg^?1 every 24 hours). In the first 24 hours, the drugs were administered intravenously (IV), and then orally for 6 (dipyrone) or 3 days (meloxicam). Prostanoids thromboxane B₂ and prostaglandin E₂ concentrations served as indicators of COX activity and, with physiological variables and pain and sedation scores, were measured for 24 hours after first analgesic administration. Rescue analgesia (tramadol, 2 mg kg^?1 IV) was provided if Glasgow feline composite measure pain scale (CMPS-Feline) ≥5. Laboratory tests included symmetric dimethylarginine and adverse effects were evaluated regularly up to 7 and 10 days after surgery, respectively. Parametric and nonparametric data were analyzed with two-way anova and Kruskal-Wallis tests, respectively (p < 0.05).ResultsIn the first half hour after analgesic administration, COX-1 activity was close to zero and remained significantly lower than before drug administration for 24 hours in all groups. The inhibition of COX-2 activity was significant for 30 minutes in all groups and up to 4 hours in group M. No alterations in laboratory tests or significant adverse effects were observed. Pain scores and need for rescue analgesia did not differ statistically among groups.ConclusionsDipyrone at both doses and meloxicam provided a nonselective inhibition of COX-1 and -2 activities and effective analgesia without causing significant adverse effects or laboratory tests alterations.Clinical relevanceDipyrone at both doses provides equally effective analgesia without causing adverse effects in cats undergoing ovariohysterectomy.  相似文献   

An inhibitor of FtsZ with potent and selective anti-staphylococcal activity     

Haydon DJ  Stokes NR  Ure R  Galbraith G  Bennett JM  Brown DR  Baker PJ  Barynin VV  Rice DW  Sedelnikova SE  Heal JR  Sheridan JM  Aiwale ST  Chauhan PK  Srivastava A  Taneja A  Collins I  Errington J  Czaplewski LG 《Science (New York, N.Y.)》2008,321(5896):1673-1675

FtsZ is an essential bacterial guanosine triphosphatase and homolog of mammalian beta-tubulin that polymerizes and assembles into a ring to initiate cell division. We have created a class of small synthetic antibacterials, exemplified by PC190723, which inhibits FtsZ and prevents cell division. PC190723 has potent and selective in vitro bactericidal activity against staphylococci, including methicillin- and multi-drug-resistant Staphylococcus aureus. The putative inhibitor-binding site of PC190723 was mapped to a region of FtsZ that is analogous to the Taxol-binding site of tubulin. PC190723 was efficacious in an in vivo model of infection, curing mice infected with a lethal dose of S. aureus. The data validate FtsZ as a target for antibacterial intervention and identify PC190723 as suitable for optimization into a new anti-staphylococcal therapy.  相似文献   

Effect of somatotropin on cells in tissue culture     

MOON HD  ST. VINCENT L 《Science (New York, N.Y.)》1957,125(3249):643-644

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A model of the anaerobic phase of ensiling   总被引：1，自引：0，他引：1  

H. D. ST C. NEAL  J. H. M. THORNLEY 《Grass and Forage Science》1983,38(2):121-134

A model of ensiling is described which incorporates the interactions of lactic acid bacteria and Clostridia with water soluble carbohydrates. The processes modelled include bacterial growth, the production of lactic and butyric acids from water soluble carbohydrates, and the conversion of lactic acid to butyric acid. The calculation of pH, and the regulation of bacterial activity by pH are important components of the model. The model predicts time courses for pH and the five State variables, which are the concentrations of water soluble carbohydrates, lactic acid, butyric acid, lactic acid bacteria and Clostridia. There is good qualitative agreement between the predictions of the model and experimental data on ensiling.  相似文献