Further characterisation of a triple resistant field isolate of Teladorsagia from a Scottish lowland sheep farm     

Bartley DJ  Jackson E  Sargison N  Jackson F 《Veterinary parasitology》2005,134(3-4):261-266

Anthelmintic efficacies against juvenile developing populations of Teladorsagia species that were known to be resistant to anthelmintics from all three broad spectrum families were examined using a controlled efficacy test. Fenbendazole (FBZ), levamisole (LEV), ivermectin (IVM), combinations of these anthelmintics and moxidectin (MOX) were assessed in parasite na?ve lambs artificially infected with 8,000 third stage larvae (Tci5) and treated orally 8-day post-infection with the compounds at the manufacturers recommended dose rates, FBZ, 5 mg/kg body weight (BW); LEV, 7.5 mg/kg BW; IVM, 0.2 mg/kg BW; MOX (0.2 mg/kg BW). The lambs were slaughtered 14-day post-treatment. The arithmetic mean worm burden reductions resulting from oral treatments with FBZ; IVM; LEV; FBZ+IVM; FBZ+LEV; FBZ, LEV+IVM or MOX were 36%, 82%, 38%, 86%, 60%, 88% and 97%, respectively. The results illustrate that combination treatments showed improved efficacies against the juvenile population compared to individually administered treatments but that these improvements were not wholly effective. Moxidectin was the only treatment that was over 95% effective, though caution should be noted when advising the use of MOX prophylactically since 3% of the infection still survived this treatment. Treatments directed at juvenile stages of Tci5 were less effective, with the exception of IVM, compared to a similar trial using Tci5 where the same treatments were directed against a predominantly adult population. No interaction was detected comparing the timings of treatments and its effectiveness with the exception of IVM (two-way ANOVA, p < 0.05). These findings suggest that, on the whole, the selection processes for anthelmintic resistance (AR) may occur at an early stage of development within the parasites, having severe implications for the early detection of AR.  相似文献   

Anthelmintic-resistant nematodes in sheep in Scotland   总被引：1，自引：0，他引：1  

Bartley D  Jackson F  Coop RL  Jackson E  Johnston K  Mitchell GB 《The Veterinary record》2001,149(3):94-95

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Performance of Australian wethers in Arabian Gulf feedlots after transport by sea     

DW SCHARP 《Australian veterinary journal》1992,69(2):42-43

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The effects of Arctotheca calendula (capeweed) on digestive function of sheep     

DW PETHICK  HM CHAPMAN 《Australian veterinary journal》1991,68(11):361-363

The effects of Arctotheca calendula (capeweed) on digestive function in the rumen, caecum and colon of sheep were studied. Three groups of 2-year-old Merino wethers were compared: 13 grazing capeweed-free pasture for 23 days; 8 fed 700 g of lucerne hay daily for 18 days, and 13 fed 6 kg of freshly cut capeweed (dry matter 11.3%) daily for 7 days. Capeweed did not cause diarrhoea and based on measurements of products of fermentation in the rumen, the plants were as nutritious as pasture containing grasses and clovers. The main disadvantage of capeweed in this single feeding trial was that sheep eating it lost body weight due to their inability, or lack of incentive, to consume enough dry matter.  相似文献   

Bloat in cattle. XVII. Wheat pasture bloat and its prevention with poloxalene.     

E E Bartley  G W Barr  R Mickelsen 《Journal of animal science》1975,41(3):752-759

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Poloxalene for treatment of cattle with alfalfa bloat     

E E Bartley  D A Stiles  R M Meyer  S F Scheidy  J G Clark  F W Boren 《Journal of the American Veterinary Medical Association》1967,151(3):339-343

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An analysis of the bloat complex and progress toward its prevention   总被引：1，自引：0，他引：1  

E E Bartley 《Journal of the American Veterinary Medical Association》1965,147(12):1397-1402

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Observations on the emergence of multiple anthelmintic resistance in sheep flocks in the south-east of Scotland     

Sargison ND  Jackson F  Bartley DJ  Wilson DJ  Stenhouse LJ  Penny CD 《Veterinary parasitology》2007,145(1-2):65-76

Multiple resistance to benzimidazole, imidazothiazole and macrocyclic lactone anthelmintics is an emerging problem in the south-east of Scotland. The general management and nematode control strategies employed in four affected flocks (flocks 1-4) were investigated in an attempt to identify the risk factors which might have led to the appearance of production limiting disease associated with anthelmintic resistance. The important risk factors for multiple anthelmintic resistance could not be confirmed and it proved easier to criticise nematode control practices on theoretical grounds, than to propose practical solutions. It seems likely that different risk factors were involved in the four flocks. Lambs in flocks 1 and 2 had been treated with an anthelmintic at 3-4 weekly intervals with the aim of achieving suppressive nematode control, while sheep in flock 1 had been treated with an anthelmintic after they were moved onto clean grazing. Recently lambed ewes had been treated with moxidectin in three of the four flocks, with the aim of controlling their periparturient rise in faecal nematode egg output. All of these factors might have contributed to the emergence of multiple anthelmintic resistance, because they could have led to anthelmintic treatments at times when the nematode population in refugia was small, compared to that in the sheep. Annual rotation of the anthelmintic group was compromised by the emergence of benzimidazole resistance and did not prevent the emergence of multiple resistance in any of the flocks described, although the practice may have slowed the development of resistance. Underdosing may have selected for benzimidazole and imidazothiazole resistance in flock 2, associated with inaccurate estimation of the weights of terminal sire lambs. These investigations also highlighted problems associated with the diagnosis of anthelmintic resistance, in particular the confounding effects of the onset of host immunity to nematode parasites, the possible influence of the age of the adult nematode population, and the insensitivity of the undifferentiated faecal egg count reduction test in situations where resistance is emerging.  相似文献   

Examining progress towards achieving the Ten Steps of the Rome Declaration on Responsible Inland Fisheries     

Abigail J. Lynch  Devin M. Bartley  Thomas Douglas Beard  Ian G. Cowx  Simon Funge‐Smith  William W. Taylor  Steven J. Cooke 《Fish and Fisheries》2020,21(1):190-203

Inland capture fisheries provide food for nearly a billion people and are important in the livelihoods of millions of households worldwide. Although there are limitations to evaluating many of the contributions made by inland capture fisheries, there is growing recognition by the international community that these services make critical contributions, most notably to food security and livelihoods in rural populations in those low‐income countries with extensive freshwater resources. With the increasing appreciation of the key role of inland fisheries to the health and well‐being of human populations globally, the Food and Agriculture Organization of the United Nations and Michigan State University convened the 2015 global conference, Freshwater, fish, and the future – cross‐sectoral approaches to sustain livelihoods, food security, and aquatic ecosystems. What emerged from the interactions between inland fisheries’ scientists, resource managers, policymakers and community representatives from across the world was a forward‐looking call to action culminating with the 2015 Rome Declaration “Ten Steps to Responsible Inland Fisheries” (FAO & MSU, Rome declaration on responsible inland fisheries: 5735E/1/06.16). Four years after this landmark conference and declaration, we seek to advance discussion on the “Ten Steps,” namely what successful implementation looks like, assess current examples of implementation, suggest potential signals of progress and provide some specific, indicative examples of progress for each step. While there are promising signs of progress, we conclude that there remains a strong need to galvanize momentum for sustained action to ensure that inland fish and fisheries are accounted for and incorporated into broader water resource management discussions and frameworks.  相似文献   

Unexpected production loss caused by helminth parasites in weaned beef calves     

Sargison ND  Wilson DJ  Penny CD  Bartley DJ 《The Veterinary record》2010,167(19):752-754

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