Equine castration: review of anatomy, approaches, techniques and complications in normal, cryptorchid and monorchid horses     

D SEARLE  AJ DART  CM DART  DR HODGSON 《Australian veterinary journal》1999,77(7):428-434

Complications associated with equine castration are the most common cause of malpractice claims against equine practitioners in North America. An understanding of the embryological development and surgical anatomy is essential to differentiate abnormal from normal structures and to minimise complications. Castration of the normal horse can be performed using sedation and regional anaesthesia while the horse is standing, or under general anaesthesia when it is recumbent. Castration of cryptorchid horses is best performed under general anaesthesia at a surgical facility. Techniques for castration include open, closed and half-closed techniques. Failure of left and right testicles to descend occurs with nearly equal frequency, however, the left testicle is found in the abdomen in 75% of cryptorchid horses compared to 42% of right testicles. Bilateral cryptorchid and monorchid horses are uncommon. Surgical approaches described for the castration of cryptorchid horses include an inguinal approach with or without retrieval of the scrotal ligament, a parainguinal approach, or less commonly a suprapubic paramedian or flank approach. Laparoscopic castration of cryptorchid horses has recently been described but the technique has limited application in practice at this time. A definitive diagnosis of monorchidism can only be made after surgical exploration of the abdomen, removal of the normal testis and hormonal testing. Hormonal assays reported to be useful include analysis of basal plasma or serum testosterone or oestrone sulphate concentrations, testosterone concentrations following hCG stimulation, and faecal oestrone sulphate concentrations. Reported complications of castration include postoperative swelling, excessive haemorrhage, eventration, funiculitis, peritonitis, hydrocele, penile damage and continued stallion-like behaviour.  相似文献   

The CO2 balance of unproductive aquatic ecosystems     

CM Duarte  S Agusti 《Science (New York, N.Y.)》1998,281(5374):234-236

Community respiration (R) rates are scaled as the two-thirds power of the gross primary production (P) rates of aquatic ecosystems, indicating that the role of aquatic biota as carbon dioxide sources or sinks depends on its productivity. Unproductive aquatic ecosystems support a disproportionately higher respiration rate than that of productive aquatic ecosystems, tend to be heterotrophic (R > P), and act as carbon dioxide sources. The average P required for aquatic ecosystems to become autotrophic (P > R) is over an order of magnitude greater for marshes than for the open sea. Although four-fifths of the upper ocean is expected to be net heterotrophic, this carbon demand can be balanced by the excess production over the remaining one-fifth of the ocean.  相似文献   

Synchronous climate changes in antarctica and the north atlantic     

EJ Steig  EJ Brook  JWC White  CM Sucher  ML Bender  SJ Lehman  DL Morse  ED Waddington  GD Clow 《Science (New York, N.Y.)》1998,282(5386):92-95

Central Greenland ice cores provide evidence of abrupt changes in climate over the past 100,000 years. Many of these changes have also been identified in sedimentary and geochemical signatures in deep-sea sediment cores from the North Atlantic, confirming the link between millennial-scale climate variability and ocean thermohaline circulation. It is shown here that two of the most prominent North Atlantic events-the rapid warming that marks the end of the last glacial period and the Bolling/Allerod-Younger Dryas oscillation-are also recorded in an ice core from Taylor Dome, in the western Ross Sea sector of Antarctica. This result contrasts with evidence from ice cores in other regions of Antarctica, which show an asynchronous response between the Northern and Southern Hemispheres.  相似文献   

Evidence for large earthquakes in metropolitan los angeles     

CM Rubin  SC Lindvall  TK Rockwell 《Science (New York, N.Y.)》1998,281(5375):398-402

The Sierra Madre fault, along the southern flank of the San Gabriel Mountains in the Los Angeles region, has failed in magnitude 7.2 to 7.6 events at least twice in the past 15,000 years. Restoration of slip on the fault indicated a minimum of about 4.0 meters of slip from the most recent earthquake and suggests a total cumulative slip of about 10.5 meters for the past two prehistoric earthquakes. Large surface displacements and strong ground motions resulting from greater than magnitude 7 earthquakes within the Los Angeles region are not yet considered in most seismic hazard and risk assessments.  相似文献   

Quantifying Transport Between the Tropical and Mid-Latitude Lower Stratosphere     

CM Volk  JW Elkins  DW Fahey  RJ Salawitch  GS Dutton  JM Gilligan  MH Proffitt  M Loewenstein  JR Podolske  K Minschwaner  JJ Margitan  KR Chan 《Science (New York, N.Y.)》1996,272(5269):1763-1768

Airborne in situ observations of molecules with a wide range of lifetimes (methane, nitrous oxide, reactive nitrogen, ozone, chlorinated halocarbons, and halon-1211), used in a tropical tracer model, show that mid-latitude air is entrained into the tropical lower stratosphere within about 13.5 months; transport is faster in the reverse direction. Because exchange with the tropics is slower than global photochemical models generally assume, ozone at mid-latitudes appears to be more sensitive to elevated levels of industrial chlorine than is currently predicted. Nevertheless, about 45 percent of air in the tropical ascent region at 21 kilometers is of mid-latitude origin, implying that emissions from supersonic aircraft could reach the middle stratosphere.  相似文献   

Nanotribology and Nanofabrication of MoO3 Structures by Atomic Force Microscopy     

PE Sheehan  CM Lieber 《Science (New York, N.Y.)》1996,272(5265):1158-1161

Atomic force microscopy was used to characterize the sliding of molybdenum oxide (MoO3) nanocrystals on single-crystal molybdenum disulfide (MoS2) surfaces. Highly anisotropic friction was observed whereby MoO3 nanocrystals moved only along specific directions of the MoS2 surface lattice. The energy per unit area to move the MoO3 nanocrystals along their preferred sliding direction was an order of magnitude less than required to slide macroscopic MoS2-bearing contacts. This extreme friction anisotropy was exploited to fabricate multicomponent MoO3 nanostructures. These reversibly interlocking structures could serve as the basis for devices such as mechanical logic gates.  相似文献   

Bovine Neonatal Pancytopenia is a heritable trait of the dam rather than the calf and correlates with the magnitude of vaccine induced maternal alloantibodies not the MHC haplotype     

Lindert Benedictus  Henny G Otten  Gerdien van Schaik  Walter GJ van Ginkel  Henri CM Heuven  Mirjam Nielen  Victor PMG Rutten  Ad P Koets 《Veterinary research》2014,45(1)

Bovine Neonatal Pancytopenia (BNP), a bleeding syndrome of neonatal calves, is caused by alloantibodies absorbed from the colostrum of particular cows. A commercial BVD vaccine is the likely source of alloantigens eliciting BNP associated alloantibodies. We hypothesized that the rare occurrence of BNP in calves born to vaccinated dams could be associated with genetic differences within dams and calves. We found that the development of BNP within calves was a heritable trait for dams, not for calves and had a high heritability of 19%. To elucidate which genes play a role in the development of BNP we sequenced candidate genes and characterized BNP alloantibodies. Alloantigens present in the vaccine have to be presented to the dam’s immune system via MHC class II, however sequencing of DRB3 showed no differences in MHC class II haplotype between BNP and non-BNP dams. MHC class I, a highly polymorphic alloantigen, is an important target of BNP alloantibodies. Using a novel sequence based MHC class I typing method, we found no association of BNP with MHC class I haplotype distribution in dams or calves. Alloantibodies were detected in both vaccinated BNP and non-BNP dams and we found no differences in alloantibody characteristics between these groups, but alloantibody levels were significantly higher in BNP dams. We concluded that the development of BNP in calves is a heritable trait of the dam rather than the calf and genetic differences between BNP and non-BNP dams are likely due to genes controlling the quantitative alloantibody response following vaccination.

Electronic supplementary material

The online version of this article (doi:10.1186/s13567-014-0129-0) contains supplementary material, which is available to authorized users.  相似文献   

Breed is associated with the ABCB1-1Δ mutation in Australian dogs     

RW Soussa  A Woodward  M Marty  CM Cannon 《Australian veterinary journal》2020,98(3):79-83

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The effects of pre-anesthetic administration of xylazine on the cardiovascular responses to dobutamine in halothane anaesthetized horses     

RM McMurphy  CM Egger  JD Lillich 《Veterinary anaesthesia and analgesia》2003,30(2):95-96

Studies evaluating the effects of dobutamine in horses do not consistently report increases in cardiac output despite increases in arterial blood pressure. The concurrent administration of the α₂ agonist clonidine, in people, inhibited the chronotropic effects of dobutamine and increased left ventricular stroke work ( Zimpfer et al. 1982 ). Our study was performed to determine if pre‐medication with an α₂ agonist affects the response to dobutamine in anaesthetized horses. Eleven horses were anaesthetized on four separate occasions for one of four randomly assigned treatments; (I) no xylazine, no dobutamine (II) xylazine, no dobutamine (III) no xylazine, dobutamine, and (IV) xylazine, dobutamine. Horses received 0.02 mg kg^?1 of butorphanol IV 10 minutes prior to anesthetic induction. Two minutes prior to induction, groups II and IV received 0.5 mg kg^?1 of IV xylazine. Anaesthesia was induced with 6–7 mg kg^?1 of thiopental and maintained with halothane. End‐tidal halothane concentrations were maintained between 1.1 and 1.2% in groups I and III, and 0.9–1.0% for groups II and IV. Heart rate, cardiac output, right atrial pressure, and systolic (SAP), diastolic (DAP) and mean (MAP) arterial pressure were recorded 30 minutes after beginning halothane anaesthesia (T10). Cardiac output was estimated using Lithium dilution ( Linton et al. 2000 ). Baseline measurements were repeated twice, at 5‐minute intervals (T5 and T0). At time 0 (T0), an IV infusion of either saline (100 mL hour^?1) or dobutamine (0.001 mg kg^?1 minute^?1) was started and data recorded at 5‐minute intervals for 30 minutes (T5 – T30). Stroke volume and systemic vascular resistance (SVR) were calculated. Data were analysed using repeated measures anova (p < 0.01 significant) and Newman–Keuls for multiple comparisons. Cardiac output and stroke volume increased over time in groups III and IV. Cardiac index was higher in groups III and IV than in groups I and II from T10 until completion of the study. Estimates of cardiac index at T30 for groups I–IV were 45 ± 9, 46 ± 11, 71 ± 11, and 78 ± 19 mL kg^?1 minute^?1, respectively (mean ± SD). Stroke index was higher in groups III and IV than in groups I and II from T15 to T30. Values for stroke index at T30 for groups I–IV were 0.98 ± 0.19, 1.11 ± 0.18, 1.46 ± 0.21, 1.74 ± 0.33 mL kg^?1. Heart rate decreased from T10–T30 in groups I and II. Heart rate was greater in groups I and III than in groups II and IV at T5 and T0. Values for heart rate at T0 for groups I–IV were 48 ± 5, 42 ± 5, 50 ± 4, 43 ± 4 beats minute^?1. Systolic arterial pressure, DAP and MAP were higher in groups III and IV than in groups I and II from T5 to T30. There were no differences in SVR between groups. Dobutamine at 0.001 mg kg^?1 minute^?1 increased cardiac output, blood pressure, and stroke volume. Premedication with xylazine at 0.5 mg kg^?1 did not appear to affect the response to dobutamine.  相似文献   

CONGENITAL MEGAESOPHAGUS WITH HYPERTROPHIC OSTEOPATHY IN A 6-YEAR-OLD DOG     

Barbara J.  Watrous  DVM  Bert  Blumenfeld  DVM 《Veterinary radiology & ultrasound》2002,43(6):545-549

Congenital megaesophagus is often sufficiently debilitating to a young puppy to result in an owner's request for euthanasia. If medically managed, some puppies may develop a functional esophagus and mature normally; in others, the dilation may persist, but nutritional support may be sufficient to allow skeletal maturation. Hypertrophic osteoarthropathy or hypertrophic osteopathy is well recognized in many animal species. Pulmonary neoplasia is most commonly associated with development of the secondary bone changes, but numerous other causes exist. The chronic changes of hypertrophic osteopathy were identified in a 6-year-old German Shepherd that was debilitated by persistent congenital megaesophagus. To the investigators' knowledge, a relationship between long-term esophageal dilatation and hypertrophic osteopathy has only been reported once in a human patient.  相似文献