Blindness in South Australian Kangaroos     

PJK DURHAM  JW FINNIE  DA LAWRENCE  P. ALEXANDER 《Australian veterinary journal》1996,73(3):111-111

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The efficacy of a controlled-release albendazole capsule in suppressing nematode burdens in sheep   总被引：3，自引：0，他引：3  

NJ BARTON  B. RODDEN†  JW STEEL‡ 《Australian veterinary journal》1990,67(11):408-410

An experiment was undertaken between July and November 1985 in East Gippsland, Victoria, to determine the efficacy of an intra-ruminal controlled-release albendazole capsule against naturally acquired worm burdens and larval challenge in Merino hoggets. Two groups of 20 sheep, one group untreated, the other dosed with a capsule were grazed together; 5 sheep from each group were slaughtered for total worm counts 30 and 101 d after capsules were administered. Serum anthelmintic concentrations, faecal egg counts and body weights were monitored. Most capsules were exhausted within 91 d of administration. During the estimated 80 d for which they remained active the capsules were highly effective against the benzimidazole-susceptible worm populations. Faecal egg counts were reduced to zero and total worm populations were reduced by over 97% 30 d after administration. By 101 d egg counts were increasing and worm counts indicated that sheep were becoming reinfected. Sheep treated with the capsules grew faster than those not treated.  相似文献   

A collapse syndrome associated with Gram-negative infection in cows treated with dexamethasone to induce parturition     

JW BROWNING  KJ SLEE  J. MALMO  P. BRIGHTLING 《Australian veterinary journal》1990,67(1):28-29

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Progressive ataxia associated with degenerative thoracic myelopathy in Merino sheep     

PAW HARPER †  JW PLANT  KH WALKER  KG TIMMINS† 《Australian veterinary journal》1991,68(11):357-358

A neurological disorder in Merino sheep, characterised clinically by progressive posterior ataxia and microscopically by Wallerian degeneration in thoracic segments of the spinal cord, is described. Animals of both sexes were affected, with the earliest onset of disease being at 5 months of age. Most affected animals died before 2 years of age. The clinical, pathological and epidemiological features suggest that this degenerative thoracic myelopathy is a previously unrecognised entity differing from other reported causes of ataxia in sheep in Australia.  相似文献   

Characterization of mRNA Expression in Preimplantation Bovine Embryos     

C Wrenzycki  D Herrmann  E Lemme  K Korsawe  JW Carnwath  H Niemann 《Reproduction in domestic animals》1998,33(3-4):307-311

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Tumour angiogenesis,anti‐angiogenic therapy and chemotherapeutic resistance          下载免费PDF全文

KA Mander  JW Finnie 《Australian veterinary journal》2018,96(10):371-378

In order for a tumour to continue to grow and disseminate, it must acquire a new blood supply. Neovascularisation can be enacted by a number of different mechanisms. This dependence of tumour progression on an augmented vascular supply has been exploited by the development of anti‐angiogenic drugs, which are designed to inhibit new blood vessel formation or disrupt existing tumour‐associated vasculature, both leading to ischaemic–hypoxic tumour cell death. However, the clinical benefits of these therapeutic approaches are frequently variable and often transient, the neoplasm sometimes being able to use other neovascularisation mechanisms to maintain its blood supply and thus evade the current anti‐angiogenic therapy. Tumours may also develop a more malignant phenotype following this treatment. Clinical outcomes may be improved by simultaneously inhibiting different angiogenic pathways, abetted by more effective drug delivery regimens such as metronomic chemotherapy and the concurrent use of other antitumour modalities.  相似文献   

Detection of Toxoplasma gondii DNA in Fresh and Frozen Semen from Rams in Brazil     

MJG Bezerra  JALO Cruz  ES Kung  PPF Albuquerque  PCP Kim  EPBX Moraes  JW Pinheiro Júnior  RA Mota 《Reproduction in domestic animals》2014,49(5):753-755

The aim of this study was to estimate the prevalence of genomic DNA of Toxoplasma gondii in semen samples from commercial rams in artificial insemination centres in Brazil, as well as in fresh semen from rams in the northeast of Brazil. In total, 108 semen samples were obtained from artificial insemination centres, and genomic DNA of T. gondii was detected in 24 of 108 (22.2%). The prevalence of antibodies anti‐Toxoplasma gondii among sheep on rural properties was 9.2% (10/109), and 100% of the semen samples of these animals were positive in the PCR for T. gondii DNA. The molecular identity was confirmed through sequencing, which indicated 99.9% similarity with the T. gondii DNA sequences stored in the GenBank. This study reports the first occurrence of T. gondii DNA in the semen of rams, which came from artificial insemination centres in Brazil, as well as the occurrence of T. gondii DNA in the fresh semen of naturally infected rams in the northeast of Brazil.  相似文献   

Drug Resistance in Equine Parasites: An Emerging Global Problem     

Heidi A. Brady  Wade T. Nichols 《Journal of Equine Veterinary Science》2009

Effective parasite control is essential for the maintenance of optimal health and performance in the horse. The worldwide escalation of parasite resistance is a major cause of concern for the horse industry. Parasite resistance to every main class of equine anthelmintic has been documented. Furthermore, dual and cross resistance also have been widely reported, despite different climatic and management practices seen throughout the world. Studies documenting parasite resistance to major classes of equine anthelmintics are discussed. Disagreement among researchers exists regarding how to effectively control equine internal parasites. Current theories of factors leading to resistance and control programs are discussed. It is clear that parasite resistance and control in the horse is an area requiring continued intensive study.  相似文献   

Effect of ophthalmic Nd:YAG laser energy on intraocular lenses after posterior capsulotomy in normal dog eyes     

Beale AB  Salmon J  Michau TM  Gilger BC 《Veterinary ophthalmology》2006,9(5):335-340

OBJECTIVE: To determine Nd:YAG laser energy requirements for posterior capsulotomy and intraocular lens (IOL) damage threshold for foldable acrylic IOLs as compared to traditional polymethylmethacrylate (PMMA). MATERIALS AND PROCEDURES: Four groups of five-six fresh canine cadaver eyes were used in this study. The groups included (1) unaltered eyes (2) aphakic eyes (3) eyes implanted with PMMA IOLs, and (4) eyes implanted with acrylic IOLs. Laser energy was delivered to the posterior capsule in grid fashion for 10 sites each of five levels of laser energy ranging from 0.5 mJ to 9 mJ. Number of successful capsulotomy sites was recorded based on slit-lamp observation. Sites of IOL damage were evaluated using scanning electron microscopy (SEM). Statistical analysis of number of capsulotomies and IOL defects per laser energy level was conducted among and between groups using anova with Tukey's HSD test. RESULTS: When comparing groups (a) including all energy levels (n = 25) and (b) by specific energy levels (n = 5), there was no significant difference (P < 0.05) in number of successful capsulotomy sites between IOL types. The 50% incidence threshold for successful capsulotomy was 2.74 mJ for acrylic IOLs and 2.64 mJ for PMMA IOLs. Energy-dependent damage to both types of IOL was detected for medium, high-medium, and high laser energy. Calculated 50% damage threshold was 4.9 mJ for acrylic IOL and 5.7 mJ for PMMA IOL. Damage to the IOL varied subjectively between IOL type, but there was no significant difference in number of defects caused, with the exception of high-medium energy. CONCLUSIONS: Both posterior lens capsules and IOLs were disrupted in an energy-dependent manner with minimal difference in number of capsulotomy sites or damage to the IOL between acrylic and PMMA IOLs. A therapeutic margin between capsulotomy threshold (2.6-2.7 mJ) and IOL damage threshold (4.9-5.7 mJ) was determined to reliably achieve capsulotomies with minimal IOL damage for both acrylic and PMMA IOLs in normal canine cadaver eyes.  相似文献   

Traumatic head injury in ruminant livestock     

JW FINNIE 《Australian veterinary journal》1997,75(3):204-208

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