Adenoviral intranuclear inclusions in lupinosis-damaged sheep livers     

RL PEET  TM ELLIS  KG ELLIOT 《Australian veterinary journal》1990,67(5):195-195

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Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX     

Chen HT  Bhandoola A  Difilippantonio MJ  Zhu J  Brown MJ  Tai X  Rogakou EP  Brotz TM  Bonner WM  Ried T  Nussenzweig A 《Science (New York, N.Y.)》2000,290(5498):1962-1965

Genetic disorders affecting cellular responses to DNA damage are characterized by high rates of translocations involving antigen receptor loci and increased susceptibility to lymphoid malignancies. We report that the Nijmegen breakage syndrome protein (NBS1) and histone gamma-H2AX, which associate with irradiation-induced DNA double-strand breaks (DSBs), are also found at sites of VDJ (variable, diversity, joining) recombination-induced DSBs. In developing thymocytes, NBS1 and gamma-H2AX form nuclear foci that colocalize with the T cell receptor alpha locus in response to recombination activating gene (RAG) protein-mediated VDJ cleavage. Our results suggest that surveillance of T cell receptor recombination intermediates by NBS1 and gamma-H2AX may be important for preventing oncogenic translocations.  相似文献