Efficacy of avermectin B₁ given orally against equine intestinal strongyles and Onchocera microfilaria     

TD MOGG †  CC POLLITT  JP WILLMORE  H. THOMPSON ‡ 《Australian veterinary journal》1990,67(11):399-401

Three groups of horses and ponies (N = 13, 13 and 12) were treated with ivermectin paste (0.2 mg/kg p.o.), avermectin B1 solution (0.2 mg/kg p.o.), or fenbendazole suspension (10 mg/kg via nasogastric tube). The avermectin B1 was a 1% solution in a propylene glycolglycerol formal base. Faecal strongyle egg counts were performed before, and 14, 28, 42, 56 and 70 d, after treatment. Full-thickness skin biopsies from the neck, pectoral and umbilical regions were examined for Onchocera microfilaria before treatment, and again 14 and 70 d later. Ivermectin therapy produced a significant (P less than 0.01) decrease in mean strongyle egg counts 14, 28, 42 and 56 d after treatment. Avermectin B1 therapy resulted in significant (P less than 0.01) decreases in mean strongyle egg counts 14, 28 and 42 d after treatment. All horses given ivermectin or avermectin B1 had zero strongyle egg counts 14 and 28 d after treatment. Fenbendazole failed to significantly decrease strongyle egg counts. Both ivermectin and avermectin B1 resulted in zero microfilaria counts in all horses 14 d after treatment. On day 70 the percentage decrease in microfilaria counts were 100% and 99.6% respectively. Fenbendazole failed to significantly decrease microfilaria counts. The oral administration of this formulation of avermectin B1 appeared to be highly efficacious against intestinal strongyles and Onchocera microfilaria. The duration of anti-strongyle activity was, however, significantly (P less than 0.01) shorter than that of ivermectin paste.  相似文献   

Prospective evaluation of the incidence of wound infection in rattlesnake envenomation in dogs          下载免费PDF全文

Amy Carr DVM  DACVECC  Jennifer Schultz DVM 《Journal of Veterinary Emergency and Critical Care》2015,25(4):546-551

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Advances in the understanding of tendinopathies: A report on the Second Havemeyer Workshop on equine tendon disease     

R. Smith  W. McIlwraith  R. Schweitzer  K. Kadler  J. Cook  B. Caterson  S. Dakin  D. Heinegård  H. Screen  S. Stover  N. Crevier‐Denoix  P. Clegg  M. Collins  C. Little  D. Frisbie  M. Kjaer  R. van Weeren  N. Werpy  J.‐M. Denoix  A. Carr  A. Goldberg  L. Bramlage  M. Smith  A. Nixon 《Equine veterinary journal》2014,46(1):4-9

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2nd International Symposium on Bluetongue, African Horse Sickness and Related Obiviruses, Paris, 17 – 21 June 1991     

TD ST  GEORGE  GI ALEXANDER  GP GARD 《Australian veterinary journal》1991,68(12):381-382

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The World in Figures     

Margaret Carr  Monique Block 《Asia Pacific viewpoint》1966,7(2):242-246

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Germination and hyphal growth of Glomus caledonicum on water agar containing benomyl     

Geoff R. Carr  Mary A. Hinkley 《Soil biology & biochemistry》1985,17(3):313-316

Concentrations of benomyl greater than 10 ng ml^?1 inhibited germination and hyphal growth of the vesicular-arbuscular mycorrhizal fungus Glomus caledonicum on water agar. This effect was attributable to only the activity of methyl-2-benzimidazole carbamate, one of the two hydrolysis products of benomyl. Hyphal growth but not germination was affected by the pH of water agar buffered with 10 mm 2-(N-morpholino)ethane sulphonic acid.  相似文献   

Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis     

Jen JC  Chan WM  Bosley TM  Wan J  Carr JR  Rüb U  Shattuck D  Salamon G  Kudo LC  Ou J  Lin DD  Salih MA  Kansu T  Al Dhalaan H  Al Zayed Z  MacDonald DB  Stigsby B  Plaitakis A  Dretakis EK  Gottlob I  Pieh C  Traboulsi EI  Wang Q  Wang L  Andrews C  Yamada K  Demer JL  Karim S  Alger JR  Geschwind DH  Deller T  Sicotte NL  Nelson SF  Baloh RW  Engle EC 《Science (New York, N.Y.)》2004,304(5676):1509-1513

The mechanisms controlling axon guidance are of fundamental importance in understanding brain development. Growing corticospinal and somatosensory axons cross the midline in the medulla to reach their targets and thus form the basis of contralateral motor control and sensory input. The motor and sensory projections appeared uncrossed in patients with horizontal gaze palsy with progressive scoliosis (HGPPS). In patients affected with HGPPS, we identified mutations in the ROBO3 gene, which shares homology with roundabout genes important in axon guidance in developing Drosophila, zebrafish, and mouse. Like its murine homolog Rig1/Robo3, but unlike other Robo proteins, ROBO3 is required for hindbrain axon midline crossing.  相似文献   

The Gelation of CO(2): A Sustainable Route to the Creation of Microcellular Materials     

Shi C  Huang Z  Kilic S  Xu J  Enick RM  Beckman EJ  Carr AJ  Melendez RE  Hamilton AD 《Science (New York, N.Y.)》1999,286(5444):1540-1543

Compounds with strong thermodynamic affinity for carbon dioxide (CO(2)) have been designed and synthesized that dissolve in CO(2), then associate to form gels. Upon removal of the CO(2), these gels produced free-standing foams with cells with an average diameter smaller than 1 micrometer and a bulk density reduction of 97 percent relative to the parent material.  相似文献   

Norepinephrine: release from brain by d-amphetamine in vivo   总被引：1，自引：0，他引：1  

L A Carr  K E Moore 《Science (New York, N.Y.)》1969,164(877):322-323

After injection of H(3)-norepinephrine into the left lateral cerebral ventricle of cats, the lateral and third cerebral ventricles were perfused with an artificial cerebrospinal fluid. Addition of d-amphetamine to the perfusion fluid caused a significant increase in the concentration of H(3)-norepinephrine in the effluent.  相似文献   

Endotoxin-stimulated opioid peptide secretion: two secretory pools and feedback control in vivo   总被引：3，自引：0，他引：3  

D B Carr  R Bergland  A Hamilton  H Blume  N Kasting  M Arnold  J B Martin  M Rosenblatt 《Science (New York, N.Y.)》1982,217(4562):845-848

Small doses of endotoxin evoked a dramatic biphasic response of opioid peptide secretion into blood in sheep. The first phase began within minutes and coincided with a brief hypertensive response to endotoxin well before the appearance of fever or hypotension. The ratio of beta-endorphin to beta-lipotropin fell abruptly at the onset of the second phase of release, suggesting early depletion of a pool rich in beta-endorphin and subsequent emergence of a pool rich in unprocessed precursor. The concentration of cerebrospinal fluid opioids increased tenfold during the second phase. Naloxone administration augmented endotoxin-induced opioid secretion in both early and late phases, suggesting a short-loop feedback regulation of stress-induced endorphin secretion.  相似文献