LOCALIZATION OF LITHIUM IN TUMOR TISSUE AS A BASIS FOR SLOW NEUTRON THERAPY     

Zahl PA  Cooper FS 《Science (New York, N.Y.)》1941,93(2403):64-65

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Diverse plant and animal genetic records from Holocene and Pleistocene sediments   总被引：1，自引：0，他引：1  

Willerslev E  Hansen AJ  Binladen J  Brand TB  Gilbert MT  Shapiro B  Bunce M  Wiuf C  Gilichinsky DA  Cooper A 《Science (New York, N.Y.)》2003,300(5620):791-795

Genetic analyses of permafrost and temperate sediments reveal that plant and animal DNA may be preserved for long periods, even in the absence of obvious macrofossils. In Siberia, five permafrost cores ranging from 400,000 to 10,000 years old contained at least 19 different plant taxa, including the oldest authenticated ancient DNA sequences known, and megafaunal sequences including mammoth, bison, and horse. The genetic data record a number of dramatic changes in the taxonomic diversity and composition of Beringian vegetation and fauna. Temperate cave sediments in New Zealand also yielded DNA sequences of extinct biota, including two species of ratite moa, and 29 plant taxa characteristic of the prehuman environment. Therefore, many sedimentary deposits may contain unique, and widespread, genetic records of paleoenvironments.  相似文献   

Uplifted marine terraces along the alpine fault, new zealand     

Bull WB  Cooper AF 《Science (New York, N.Y.)》1986,234(4781):1225-1228

Three types of evidence indicate that marine terraces are widespread in the Southern Alps of New Zealand. (i) Remnants of shore platforms occur as distinct levels of notched ridge crests and flat summits; degraded sea cliffs are common. (ii) Scattered quartz beach pebbles occur on 16 of 18 levels of exhumed shore platforms in the Fox- Franz Josef type area to altitudes as high as 1700 meters. (iii) Altitudinal spacings of New Zealand terrace flights allow correlation with 18 dated global marine terraces at New Guinea, which were formed during glacio-eustatic highstands of sea level within the last 336 x 10(3) years. Inferred uplift rates at Fox-Franz Josef increased from 3.2 to 7.8 meters per 10(3) years since about 135 x 10(3) to 140 x 10(3) years ago, presumably because of increased convergence between the Pacific and Australian plates.  相似文献   

Cellular transforming genes   总被引：65，自引：0，他引：65  

G M Cooper 《Science (New York, N.Y.)》1982,217(4562):801-806

Cellular genes potentially capable of inducing oncogenic transformation have been identified by homology to the transforming genes of retroviruses and by the biological activity of cellular DNA's in transfection assays. DNA's of various tumors induce transformation with high efficiencies, indicating that oncogenesis can involve dominant genetic alterations resulting in activation of cellular transforming genes. The identification and characterization of cellular transforming genes and their possible involvement in naturally occurring cancers, is discussed.  相似文献   

Multimodal signals: enhancement and constraint of song motor patterns by visual display     

Cooper BG  Goller F 《Science (New York, N.Y.)》2004,303(5657):544-546

Many birds perform visual signals during their learned songs, but little is known about the interrelationship between visual and vocal displays. We show here that male brown-headed cowbirds (Molothrus ater) synchronize the most elaborate wing movements of their display with atypically long silent periods in their song, potentially avoiding adverse biomechanical effects on sound production. Furthermore, expiratory effort for song is significantly reduced when cowbirds perform their wing display. These results show a close integration between vocal and visual displays and suggest that constraints and synergistic interactions between the motor patterns of multimodal signals influence the evolution of birdsong.  相似文献   

THE GOLDEN HAMSTER (CRICETUS AURATUS) AS A TEST ANIMAL FOR THE DIAGNOSIS OF LEPTOSPIROSIS     

Randall R  Cooper HK 《Science (New York, N.Y.)》1944,100(2589):133-134

There is evidence that the golden hamster (Cricetus auratus) is the animal of choice for the isolation of leptospirae, especially of the Leptospira canicola type since young guinea pigs and mice are resistant to infection and rats are entirely refractory. Both the classical strain, L. icterohaemorrhagiae and L. canicola on isolation have been found to produce a fatal infection in hamsters. The present report deals with the isolation of L. canicola in two instances by the injection intraperitoneally into hamsters of urine obtained from dogs ill with suspected leptospirosis. Each of the dogs was apparently the source of infection for a human case of Canicola leptospirosis. The classical strain L. icterohaemorrhagiae was isolated from the dog for the first time in the United States. In this instance the organism was isolated by injecting both whole blood and urine from the patient intraperitoneally into young hamsters. The injection into hamsters of suitable material from patients infected with L. canicola and L. icterohaemorrhagiae is followed by a fatal leptospirosis in the test animal.  相似文献   

Defect in vitamin B12 release from lysosomes: newly described inborn error of vitamin B12 metabolism   总被引：5，自引：0，他引：5  

D S Rosenblatt  A Hosack  N V Matiaszuk  B A Cooper  R Laframboise 《Science (New York, N.Y.)》1985,228(4705):1319-1321

Cultured diploid fibroblasts from a patient with a previously undescribed inborn error of cobalamin metabolism accumulate unmetabolized, nonprotein-bound vitamin B12 in lysosomes. These cells are able to endocytose the transcobalamin II-B12 complex and to release B12 from transcobalamin II. The freed vitamin B12 is not released from lysosomes into the cytoplasm of the cell. This suggests that there is a specific lysosomal transport mechanism for vitamin B12 in the human.  相似文献   

The cost of R & d living     

Berger M  Cooper MJ 《Science (New York, N.Y.)》1979,204(4400):1369

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Climate. Society and sea level rise     

Pilkey OH  Cooper JA 《Science (New York, N.Y.)》2004,303(5665):1781-1782

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Isoprenoid acids in recent sediments     

Blumer M  Cooper WJ 《Science (New York, N.Y.)》1967,158(3807):1463-1464

Phytanic acid, pristanic acid, and 4,8,12-trimethyltridecanoic acid have been isolated from three recent marine sediments. The ratio of palmitic to pristanic acid is similar to that encountered in typical marine lipids. This suggests a biochemical origin of these sedimentary acids; phytol is their presumed biochemical precursor. Other isoprenoid acids between C(11) and C(22) which are common in ancient sediments have not been found. They are probably geochemical products formed slowly and at a greater depth.  相似文献