Comparative functional characterization of canine IgG subclasses     

Lisa M. Bergeron  Erin E. McCandless  Steve Dunham  Bill Dunkle  Yaqi Zhu  John Shelly  Sandra Lightle  Andrea Gonzales  Graeme Bainbridge 《Veterinary immunology and immunopathology》2014,157(1-2):31-41

To date, very little is known about the functional characteristics of the four published canine IgG subclasses. It is not clear how each subclass engages the immune system via complement-dependent cytotoxicity (CDC) or antibody-dependent cell-mediated cytotoxicity (ADCC), or how long each antibody may last in serum. Such information is critical for understanding canine immunology and for the discovery of canine therapeutic monoclonal antibodies. Through both in vitro and ex vivo experiments to evaluate canine Fc's for effector function, complement binding, FcRn binding, and ADCC, we are now able to categorize canine subclasses by function. The subclasses share functional properties with the four human IgG subclasses and are reported herein with their function-based human analog. Canine Fc fusions, canine chimeras, and caninized antibodies were characterized. Canine subclasses A and D appear effector-function negative while subclasses B and C bind canine Fc gamma receptors and are positive for ADCC. All canine subclasses bind the neonatal Fc receptor except subclass C. By understanding canine IgGs in this way, we can apply what is known of human immunology toward translational and veterinary medicine. Thus, this body of work lays the foundation for evaluating canine IgG subclasses for therapeutic antibody development and builds upon the fundamental scholarship of canine immunology.  相似文献   

Highly pathogenic avian influenza virus infection in chickens but not ducks is associated with elevated host immune and pro-inflammatory responses     

Suresh V Kuchipudi  Meenu Tellabati  Sujith Sebastian  Brandon Z Londt  Christine Jansen  Lonneke Vervelde  Sharon M Brookes  Ian H Brown  Stephen P Dunham  Kin-Chow Chang 《Veterinary research》2014,45(1)

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High-sulfur coal for generating electricity     

Dunham JT  Rampacek C  Henrie TA 《Science (New York, N.Y.)》1974,184(4134):346-351

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Prevention and treatment of injection-site sarcomas     

DW Macy  C Guillermo Couto 《Journal of Feline Medicine and Surgery》2001,3(4):169-170

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Noise reactivity in three breeds of herding dogs: What the crossroads of demography,ethology, and genetics can tell us     

Karen Overall  Steven P. Hamilton  Melanie Lee Chang  Jennifer S. Yokoyama  Donna J. Dyer  Arthur E. Dunham  Nicholas Branson  Soraya Juarbe-Diaz 《Journal of Veterinary Behavior: Clinical Applications and Research》2009,4(2):70-71

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A 0.5-million-year record of millennial-scale climate variability in the north atlantic   总被引：8，自引：0，他引：8  

JF McManus  DW Oppo  JL Cullen 《Science (New York, N.Y.)》1999,283(5404):971-975

Long, continuous, marine sediment records from the subpolar North Atlantic document the glacial modulation of regional climate instability throughout the past 0.5 million years. Whenever ice sheet size surpasses a critical threshold indicated by the benthic oxygen isotope (delta18O) value of 3.5 per mil during each of the past five glaciation cycles, indicators of iceberg discharge and sea-surface temperature display dramatically larger amplitudes of millennial-scale variability than when ice sheets are small. Sea-surface temperature oscillations of 1 degrees to 2 degreesC increase in size to approximately 4 degrees to 6 degreesC, and catastrophic iceberg discharges begin alternating repeatedly with brief quiescent intervals. The glacial growth associated with this amplification threshold represents a relatively small departure from the modern ice sheet configuration and sea level. Instability characterizes nearly all observed climate states, with the exception of a limited range of baseline conditions that includes the current Holocene interglacial.  相似文献   

Phase velocities of rayleigh waves in the MELT experiment on the east pacific rise   总被引：2，自引：0，他引：2  

DW Forsyth  SC Webb  LM Dorman  Y Shen 《Science (New York, N.Y.)》1998,280(5367):1235-1238

The phase velocities of Rayleigh waves increase more rapidly with distance from the East Pacific Rise (EPR) axis than is predicted by models of conductive cooling of the lithosphere. Low velocities near the axis are probably caused by partial melt at depths of 20 to 70 kilometers in a zone several hundred kilometers wide. The lowest velocities are offset to the west of the EPR. Wave propagation is anisotropic; the fast direction is approximately perpendicular to the ridge, parallel to the spreading direction. Anisotropy increases from a minimum near the axis to 3 percent or more on the flanks.  相似文献   

Predatory dinosaur remains from madagascar: implications for the cretaceous biogeography of gondwana   总被引：1，自引：0，他引：1  

SD Sampson  LM Witmer  CA Forster  DW Krause  PM O'Connor  P Dodson  F Ravoavy 《Science (New York, N.Y.)》1998,280(5366):1048-1051

Recent discoveries of fossil vertebrates from the Late Cretaceous of Madagascar include several specimens of a large theropod dinosaur. One specimen includes a nearly complete and exquisitely preserved skull with thickened pneumatic nasals, a median frontal horn, and a dorsal projection on the parietals. The new materials are assigned to the enigmatic theropod group Abelisauridae on the basis of a number of unique features. Fossil remains attributable to abelisaurids are restricted to three Gondwanan landmasses: South America, Madagascar, and the Indian subcontinent. This distribution is consistent with a revised paleogeographic reconstruction that posits prolonged links between these landmasses (via Antarctica), perhaps until late in the Late Cretaceous.  相似文献   

Effects of Varying Dietary Protein Levels and Feeding Frequencies on Condition and Reproductive Performance of Channel Catfish to Produce Hybrid Catfish     

Herbert E. Quintero  Alison Hutson  Atra Chaimongkol  Allen Davis  Rex Dunham  Asheber Abebe 《Journal of the World Aquaculture Society》2009,40(5):601-615

The interspecific hybridization of channel catfish, Ictalurus punctatus, females with blue catfish, I. furcatus, males has been identified as a method to further improve production; however, lack of spawning success has affected its commercial application. To facilitate our understanding of the interaction of brood stock nutrition and reproductive performance, we evaluated the interaction of feed quality and feeding frequency. Channel catfish females were classified into two genetic groups, namely, high and low spawning. The treatments were offered during the spring season 70–90 d prior to the start of the spawning season. Induced reproduction was performed using luteinizing hormone releasing hormone analog. Condition of the fish as well as reproductive performance using spawning success, egg production, egg size, and fertilization at 48 h were determined. Changing protein level of the diet from 32 to 42% did not influence spawning, fecundity, or fertilization, but affected egg size and biochemical composition of the eggs. Increasing the feeding frequency from three to six times per week negatively affected spawning in one of the two genetics groups, did not affect egg production and egg fertilization, but had a significant effect on egg size. Older fish performed better than younger fish in terms of spawning success and egg production.  相似文献