Effect of fentanyl on the induction dose and minimum infusion rate of alfaxalone preventing movement in female dogs     

Katherine Bennett  Reza Seddighi  Kaitlin Moorhead  Kristen Messenger  Sherry Cox  Xiaocun Sun  Kirby Pasloske  Thomas Doherty 《Veterinary anaesthesia and analgesia》2018,45(6):885.e2-885.e3

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Effect of cattle breed on innate resistance to inoculations of Babesia bigemina     

RE BOCK  TG KINGSTN  NF STANDFAST  AJ de  VOS 《Australian veterinary journal》1999,77(7):465-466

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The Effect of Sedation on Gastric Emptying of a Liquid Marker in Ponies     

Thomas J. Doherty  MVB  MSc  Diplomate ACVA    Frank M. Andrews  DVM  MS  Diplomate ACVIM    Melanie K. Provenza  BS    Donita L. Frazier  DVM  PhD  Diplomate ABVT 《Veterinary surgery : VS》1999,28(5):375-379

OBJECTIVE: The effect of sedation on gastric emptying was evaluated in six ponies by monitoring serum concentrations of acetaminophen (AP) after intragastric administration. EXPERIMENTAL DESIGN: Prospective randomized experimental study. ANIMALS: Six adult ponies, 135 to 275 kg. METHODS: Fifteen minutes after the intravenous administration of xylazine (1 mg/kg), butorphanol (0.05 mg/kg), acepromazine (0.05 mg/kg) or saline, ponies were given AP (20 mg/kg in 350 mL water) by stomach tube. Blood for AP analysis was collected at baseline and 15, 30, 45, 75, 90, 105, and 120 minutes after AP administration. The time (Tmax) to reach peak serum concentration (Cmax), and the area under the AP serum concentration versus time curve (AUC) were determined for each treatment group. RESULTS: Tmax was 31 mins in the control group, and this increased significantly (P<.05) after sedation. Cmax decreased (P<.05) after xylazine administration, and AUC decreased (P<.05) after acepromazine. CONCLUSIONS: This study indicated that sedation has a significant effect on the gastric emptying rate of a liquid in ponies.  相似文献   

Effects of orally administered enteric-coated omeprazole on gastric acid secretion in horses.     

F M Andrews  T J Doherty  J T Blackford  J A Nadeau  A M Saxton 《American journal of veterinary research》1999,60(8):929-931

OBJECTIVES: To determine the effects of orally administered omeprazole, as enteric-coated capsules, on baseline and stimulated gastric acid secretion in horses. ANIMALS: 5 healthy 8-year-old mixed-breed horses fitted with gastric cannulas. PROCEDURE: Enteric-coated granules of omeprazole were mixed with corn syrup and administered orally once daily for 5 consecutive days. On days 1 and 5 beginning 5 hours after omeprazole administration, 4 gastric fluid samples were collected, each for 15 minutes, via the gastric cannula (baseline samples). Pentagastrin was administered IV as a constant infusion for the subsequent 2 hours, and 15-minute gastric fluid samples were again collected (stimulated samples). Fluid volume, acidity (mmol H-/L), and pH and gastric acid production (mmol H+) were determined for all baseline samples and for stimulated samples collected during the second hour of pentagastrin infusion. Control experiments were done in a similar manner after giving corn syrup alone to the same horses. RESULTS: Compared with values obtained during control experiments, baseline and stimulated gastric fluid acidity and gastric acid production significantly decreased, and the mean pH of gastric fluid samples significantly increased, after horses were given 5 daily doses of omeprazole. CONCLUSIONS AND CLINICAL RELEVANCE: Enteric-coated omeprazole (1.0 mg/kg of body weight; PO) administered once daily for 5 days significantly inhibited unstimulated and pentagastrin-stimulated gastric acid secretion in horses. This commercially available formulation of omeprazole may be efficacious in the treatment of gastroduodenal ulcers in horses.  相似文献   

Metoclopramide ameliorates the effects of endotoxin on gastric emptying of acetaminophen in horses.   总被引：2，自引：1，他引：1       下载免费PDF全文

T J Doherty  F M Andrews  T W Abraha  D Osborne    D L Frazier 《Canadian journal of veterinary research》1999,63(1):37-40

The effect of metoclopramide on gastric emptying of a liquid marker in horses was evaluated by measuring serum concentrations of acetaminophen. Gastric emptying was determined in normal, fasted horses (n = 7), horses given endotoxin intravenously (n = 7), and horses given intravenous metoclopramide plus endotoxin (n = 6). The mean time to reach maximum serum acetaminophen concentration (Tmax), the maximum serum concentration (Cmax), and the area under the serum acetaminophen concentration vs time curve (AUC) were compared among treatment groups. Endotoxin caused a profound delay in gastric emptying, and pretreatment with metoclopramide significantly (P < 0.05) ameliorated this effect.  相似文献   

A serological survey of salmon pancreas disease virus (SPDV) antibodies in farmed Atlantic salmon,Salmo salar L.     

McLoughlin  Rowley  Doherty 《Journal of fish diseases》1998,21(4):305-307

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Data worth and prediction uncertainty for pesticide transport and fate models in Nebraska and Maryland,United States          下载免费PDF全文

Bernard T Nolan  Robert W Malone  John E Doherty  Jack E Barbash  Liwang Ma  Dale L Shaner 《Pest management science》2015,71(7):972-985

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Surgical resection of a dysgerminoma in a mare   总被引：1，自引：1，他引：0  

S Harland  CS Smith  TD Mogg  N Horadagoda  AJ Dart 《Australian veterinary journal》2009,87(3):110-112

A mare was referred for further evaluation of a mass found in the left caudal abdomen during a routine postpartum reproductive palpation. The mare was clinically normal with no history of health problems. Ultrasonographic examination of the mass confirmed its presence, but the origin of the mass could not be accurately determined. Routine haematology and serum biochemistry results were within normal limits. The mare was initially treated conservatively with antibiotics, but the mass continued to increase in size, so it was surgically excised. The mass involved the left ovary. The mare showed transient abdominal pain after surgery, but developed no other complications and was in foal 7 months later. On histology, the mass was diagnosed as a dysgerminoma, a rare ovarian tumour of germ cell origin.  相似文献   

Equine amnionitis and fetal loss: The case definition for an unrecognised cause of abortion in mares     

KH Todhunter  NR Perkins  RM Wylie  C Chicken  AJ Blishen  DJ Racklyeft  G Muscatello  MC Wilson  PL Adams  JR Gilkerson  WL Bryden  AP Begg 《Australian veterinary journal》2009,87(1-2):35-38

A series of abortions occurred in mares in New South Wales during 2004 that involved similar and unusual findings on post mortem examination of aborted fetuses and fetal membranes. The term Equine Amnionitis and Fetal Loss (EAFL) was developed to describe the condition. This form of abortion had not been previously recognised in Australia. The pathology alone is not specific for EAFL and diagnosis requires demonstration of a combination of certain pathological and bacteriological features. The purpose of this paper is to describe patterns considered consistent with EAFL cases as a working case definition for use by veterinarians and veterinary pathologists in identifying future cases of EAFL. More detailed papers are in preparation to fully describe the epidemiological, histopathological, and microbiological aspects of EAFL.  相似文献   

Effect of fentanyl on the induction dose and minimum infusion rate of propofol preventing movement in dogs     

Carrie A. Davis  Reza Seddighi  Sherry K. Cox  Xiaocun Sun  Christine M. Egger  Thomas J. Doherty 《Veterinary anaesthesia and analgesia》2017,44(4):727-737

Objective

To determine the effect of fentanyl on the induction dose of propofol and minimum infusion rate required to prevent movement in response to noxious stimulation (MIR_NM) in dogs.

Study design

Crossover experimental design.

Animals

Six healthy, adult intact male Beagle dogs, mean ± standard deviation 12.6 ± 0.4 kg.

Methods

Dogs were administered 0.9% saline (treatment P), fentanyl (5 μg kg^?1) (treatment PLDF) or fentanyl (10 μg kg^?1) (treatment PHDF) intravenously over 5 minutes. Five minutes later, anesthesia was induced with propofol (2 mg kg^?1, followed by 1 mg kg^?1 every 15 seconds to achieve intubation) and maintained for 90 minutes by constant rate infusions (CRIs) of propofol alone or with fentanyl: P, propofol (0.5 mg kg^?1 minute^?1); PLDF, propofol (0.35 mg kg^?1 minute^?1) and fentanyl (0.1 μg kg^?1 minute^?1); PHDF, propofol (0.3 mg kg^?1 minute^?1) and fentanyl (0.2 μg kg^?1 minute^?1). Propofol CRI was increased or decreased based on the response to stimulation (50 V, 50 Hz, 10 mA), with 20 minutes between adjustments. Data were analyzed using a mixed-model anova and presented as mean ± standard error.

Results

ropofol induction doses were 6.16 ± 0.31, 3.67 ± 0.21 and 3.33 ± 0.42 mg kg^?1 for P, PLDF and PHDF, respectively. Doses for PLDF and PHDF were significantly decreased from P (p < 0.05) but not different between treatments. Propofol MIR_NM was 0.60 ± 0.04, 0.29 ± 0.02 and 0.22 ± 0.02 mg kg^?1 minute^?1 for P, PLDF and PHDF, respectively. MIR_NM in PLDF and PHDF was significantly decreased from P. MIR_NM in PLDF and PHDF were not different, but their respective percent decreases of 51 ± 3 and 63 ± 2% differed (p = 0.035).

Conclusions and clinical relevance

Fentanyl, at the doses studied, caused statistically significant and clinically important decreases in the propofol induction dose and MIR_NM.  相似文献