Radiographic anatomy of the articular process joints of the caudal cervical vertebrae in the horse on lateral and oblique projections     

J. M. WITHERS  L. C. VOÛTE  G. HAMMOND  C. J. LISCHER 《Equine veterinary journal》2009,41(9):895-902

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Dose–Response Studies for Pituitary and Testicular Function in Male Dogs Treated with the GnRH Superagonist, Deslorelin     

A Junaidi  PE Williamson  GB Martin  MA Blackberry  JM Cummins  TE Trigg 《Reproduction in domestic animals》2009,44(5):725-734

We tested the effect of dose of GnRH superagonist on pituitary and testicular function in a study with four groups of four male dogs. The Controls received blank implants and the other three groups received implants containing 3, 6 or 12 mg deslorelin (d ‐Trp⁶‐Pro⁹‐des‐Gly¹⁰‐GnRH ethylamide). In all deslorelin‐treated groups, there was initially an acute increase in plasma concentrations of LH and testosterone, followed by declines such that both hormones became undetectable after approximately 12 days. There was a dose–response in some of these early aspects of the hormone profiles. With respect to long‐term effects of treatment, the 12‐mg dose had significantly greater effects than the smaller doses for the duration of minimum testicular volume [366 ± 77, mean ± SEM (3 mg), 472 ± 74 (6 mg), and 634 ± 59 (12 mg) days], absence of ejaculate [416 ± 88 (3 mg), 476 ± 83 (6 mg), and 644 ± 67 (12 mg) days], undetectable plasma concentrations of LH and testosterone [367 ± 64 (3 mg), 419 ± 72 (6 mg), and 607 ± 69 (12 mg) days], the delay until complete recovery of LH and testosterone secretion [394 ± 65 (3 mg), 484 ± 72 (6 mg) and 668 ± 47 (12 mg) days], and the delay until testes had regrown to normal volume [408 ± 77 (3 mg), 514 ± 74 (6 mg), 676 ± 59 (12 mg) days]. The time taken to restore full ejaculates was also longest for the 12‐mg dose: 716 ± 67 (12 mg) days vs 440 ± 66 (3 mg) and 538 ± 83 (6 mg) days after implantation. There was no correlation between delay to recovery of normal ejaculate quality and body mass. We conclude that the dose–response relationship with deslorelin implants is not expressed with respect to the degree of suppression of reproduction, but on the maximum duration of suppression and thus to delay until recovery.  相似文献   

Pharmacogenetics: it's not just about ivermectin in collies     

Dowling P 《The Canadian veterinary journal. La revue veterinaire canadienne》2006,47(12):1165-1168

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Limiting antimicrobial resistance--your mother was right!     

Dowling PM 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2006,20(1):1-2

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Clinical pharmacology update. Insulin     

Dowling P 《The Canadian veterinary journal. La revue veterinaire canadienne》2006,47(7):711-2, 714-5

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Seasonal Changes in Arsenic Concentrations and Hydrogeochemistry of Canadian Creek, Ballarat (Victoria, Australia)     

Khawar Sultan  Kim Dowling 《Water, air, and soil pollution》2006,169(1-4):355-374

A 10-month study of surface waters in Canadian Creek (Ballarat, Victoria, Australia) showed the significant influence of historic gold mining waste material. The investigation focussed on the hydrogeochemistry of the surface waters and soils in order to: (1) document the levels and seasonal trends in major, minor and trace elements in the creek, (2) identify the process by which As is released from the soil/waste mining material to surface waters. For most dissolved major and trace elements (Na, Ca, Mg, K, and As) in surface waters, the concentrations decreased with the increasing rainfall and flow conditions except for Al and Fe. Two sites selected along the creek (< 1 km apart) allowed evaluation of the possibility that mining waste material is contributing to the elevated As concentrations (up to 145 μg/l) in downstream surface water. Arsenic concentration varied more than 28 fold seasonally and was highest in autumn and lowest in spring. Elevated concentrations of As (up to 1946 mg/kg) at the downstream site indicated the presence of a source of As concentration in both surface and subsurface soils. Oxidation of arsenic sulphides under aerobic conditions with redox fluctuations (7 to 201 mV) could cause elevated As levels in the creek. Significant statistical correlations among the major cations (Ca, Na and Mg) point to a common source(s) resulting in neutral to slightly alkaline (pH ～ 6.5 to 7.8) surface water. Fe and Al secondary phases under oxidising conditions are a significant controlling mechanism for the mobilization of As in highly contaminated soils (> 1500 mg/kg) in the study area. The large As adsorption capacity of Fe and Al could be limiting extreme mobilization into the water. Rainfall with relatively low pH is possibly causing mobilisation of Al, Fe and As from highly alkaline soils (pH ≈ 9.0) into the nearby creek.  相似文献   

Support for AVA''s horse culling response     

Dr  Laurie Dowling 《Australian veterinary journal》2000,78(12):815-815

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Severe renal oxalosis in five young Beefmaster calves.     

J C Rhyan  E A Sartin  R D Powers  D F Wolfe  P M Dowling  J S Spano 《Journal of the American Veterinary Medical Association》1992,201(12):1907-1910

Severe renal oxalosis was diagnosed in 4 male and 1 female purebred Beefmaster calves from herds in southeastern and northwestern United States. Clinical signs included weakness, anorexia, lethargy, alopecia, dehydration, and diarrhea. Results of serum biochemical analysis for 2 calves were consistent with end-stage renal disease. Calves died 2 days to 6 weeks after birth. At necropsy, renal calyces were dilated and contained pale yellow granular calculi. Histologically, there was renal interstitial fibrosis, and cortical and medullary tubules were distended with calcium oxalate crystals. Oxalate crystals were also in the tracheal glands of 1 calf. Severe renal oxalosis in young purebred calves, on widely varied diets, with no known exposure to exogenous oxalates is suggestive of an inherited metabolic defect resulting in primary hyperoxaluria.  相似文献   

Veterinary Pharmacology and Therapeutics          下载免费PDF全文

Patricia M. Dowling 《The Canadian veterinary journal. La revue veterinaire canadienne》1996,37(12):756

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Antimicrobial Therapy in Veterinary Medicine, 2nd ed     

Patricia M. Dowling 《The Canadian veterinary journal. La revue veterinaire canadienne》1995,36(2):120

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