Expression and localization of BCRP,MRP1 and MRP2 in intestines,liver and kidney in horse     

E. TYDÉN  H. BJŐRNSTRŐM  H. TJÄLVE  P. LARSSON 《Journal of veterinary pharmacology and therapeutics》2010,33(4):332-340

Tydén, E., Bj?rnstr?m, H., Tjälve, H., Larsson, P. Expression and localization of BCRP, MRP1 and MRP2 in intestines, liver and kidney in horse. J. vet. Pharmacol. Therap. doi: 10.1111/j.1365‐2885.2009.01140.x. The gene and protein expression and the cellular localization of the ABC transport proteins breast cancer resistance protein (BCRP), multidrug resistance‐associated protein 1 (MRP1) and multidrug resistance‐associated protein 2 (MRP2) have been examined in the intestines, liver and kidney in horse. High gene and protein expression of BCRP and MRP2 were found in the small intestines, with cellular localization in the apical membranes of the enterocytes. In the liver, MRP2 was present in the bile canalicular membranes of the hepatocytes, whereas BCRP was localized in the cytoplasm of hepatocytes in the peripheral parts of the liver lobuli. In the kidney both BCRP and MRP2 were predominantly present in the distal tubuli and in the loops of Henle. In most tissues, the gene and protein expression of MRP1 were much lower than for BCRP and MRP2. Immunostaining of MRP1 was detectable only in the intestines and with localization in the cytoplasm of enterocytes in the caecum and colon and in the cells of serous acini of Brunner’s glands in the duodenum and the upper jejunum. The latter cells were also stained for BCRP, but not for MRP2. Many drugs used in horse are substrates for one or more of the ABC transport proteins. These transporters may therefore have important functions for oral bioavailability, distribution and excretion of substrate compounds in horse.  相似文献   

Effects of an insecticidal dip containing d-limonene in the cat     

S B Hooser  V R Beasley  J I Everitt 《Journal of the American Veterinary Medical Association》1986,189(8):905-908

A study was undertaken to determine the effects of a single dermal application of a commercial insecticidal dip containing 78.2% d-limonene in cats. At the manufacturer's recommended concentration of 1.5 oz/gal of water, no clinical signs or lesions of toxicosis were seen. At 5 times the recommended concentration, clinical signs were mild and consisted of hypersalivation of short duration, ataxia, and muscle tremors resembling shivering. At 15 times the recommended concentration, clinical signs included hypersalivation lasting 15 to 30 minutes, moderate-to-severe ataxia lasting 1 to 5 hours, muscle tremors resembling shivering lasting 1 to 4 hours, and severe hypothermia beginning soon after treatment and lasting 5 hours. Gross lesions were confined to excoriation of the scrotal and perineal areas of the treated male cats at the 15 X concentration. No deaths or other lasting effects were seen at any dosage.  相似文献   

The effects of different anesthetics on blood steroid concentrations in domestic tom-cats     

IP JOHNSTONE  BJ BANCROFT 《Australian veterinary journal》1988,65(12):382-385

Testosterone and androstenedione were measured in the plasma of mature tom-cats before, during and after anesthesia with thiopentone, ketamine, xylazine and alphaxolone/alphadolone. Samples were collected via an indwelling jugular catheter at 30 min intervals before anesthesia (5 samples) and during the recovery phase (8 samples), and at intervals of 15 min during anesthesia (7 samples). Thiopentone and ketamine anesthesia significantly depressed testosterone and androstenedione concentrations during and after anesthesia. Xylazine significantly increased testosterone concentrations during anesthesia but they returned to pre-anesthetic concentrations during recovery. Androstenedione concentrations were significantly depressed during the recovery phase from xylazine anesthesia. Alphaxolone/alphadolone anesthesia had no significant effect of testosterone concentrations but significantly increased and androstenedione concentrations during anesthesia and recovery. Testosterone and androstenedione concentrations in cats were significantly altered by these 4 commonly used anesthetics and this must be taken into account if hormone concentrations are measured while cats are anesthetised.  相似文献   

Antifungal non‐invasive soak under general anaesthetic to treat fungal rhinitis in an Australian Quarter Horse gelding at pasture          下载免费PDF全文

NE Lean  BJ Ahern 《Australian veterinary journal》2018,96(8):297-301

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Ataxia and paralysis in cats in Australia associated with exposure to an imported gamma-irradiated commercial dry pet food   总被引：1，自引：1，他引：0  

G Child  DJ Foster  BJ Fougere  JM Milan  M Rozmanec 《Australian veterinary journal》2009,87(9):349-351

Between June 2008 and March 2009, 87 cats in Australia developed symmetrical hindlimb ataxia, paraparesis, tetraparesis, paraplegia or tetraplegia in association with eating an imported, irradiated dry pet food. This communication reports the clinical signs and outcomes of those cats.  相似文献   

Book Review     

BJ McDonald 《Australian veterinary journal》2005,83(6):352-352

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Posthumous inspirations     

Everitt CW 《Science (New York, N.Y.)》1993,259(5094):536-537

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Small Animal ECGs: An Introduction - by M Martin     

BJ Gavaghan 《Australian veterinary journal》2008,86(7):271-271

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Long‐Term Outcome in Dogs After Circumcostal Gastropexy or Gastrocolopexy for Gastric Dilatation With or Without Volvulus     

ANNA V. EGGERTSDÓTTIR DVM  PhD  MARIANNE LANGELAND DVM  PhD  BJØRN FUGLEM DVM  ANE MOHN DVM  ØYVIND STIGEN DVM  PhD 《Veterinary surgery : VS》2008,37(8):809-810

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Primary optic nerve meningiomas in F344 rats     

K Yoshitomi  J I Everitt  G A Boorman 《Veterinary pathology》1991,28(1):79-81

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