Evaluation of butorphanol-azaperone-medetomidine in captive cheetah (Acinonyx jubatus) immobilization     

Aleksandr Semjonov  Jacobus P. Raath  Liesel Laubscher  Toomas Orro  Silke Pfitzer  Toomas Tiirats  Peter Stewart Rogers  Vladimir Andrianov 《Veterinary anaesthesia and analgesia》2019,46(1):90-95

Objective

The butorphanol-azaperone-medetomidine fixed-dose combination (BAM, respectively, 30-12-12 mg mL^?1) with subsequent antagonism by naltrexone-atipamezole was evaluated for reversible immobilization of captive cheetahs (Acinonyx jubatus).

Study design

Prospective, clinical trial.

Animals

Twelve cheetahs (six males and six females, weighing 37–57 kg) housed in enclosures, were immobilized at Hoedspruit Endangered Species Centre in the Republic of South Africa.

Methods

BAM volume dose rate was 0.009–0.014 mL kg^?1 (mean ± standard deviation 0.010 ± 0.001 mL kg^?1). Total dose in all animals was 0.5 mL. The actual doses were as follows: butorphanol (0.29 ± 0.04 mg kg^?1), azaperone (0.12 ± 0.01 mg kg^?1) and medetomidine (0.12 ± 0.01 mg kg^?1). Physiologic variables and quality of immobilization were recorded every 5 minutes beginning at 15–20 minutes after darting. Arterial blood samples were collected three times at 20, 30 and 40 minutes after darting from all animals for analysis of blood oxygenation and acid-base status.

Results

The inductions were calm and smooth and mean induction time was 4.0 ± 1.1 minutes. Heart rate (50 ± 9 beats minute^?1) and respiratory frequency (20 ± 3 breaths minute^?1) were stable throughout immobilization. The recovery time after reversing with naltrexone and atipamezole was 9.1 ± 3.6 minutes.

Conclusions

and clinical relevance BAM proved to be a reliable and cardiovascular stable drug combination for immobilization of cheetahs.  相似文献   

Ultrasonographic evaluation of vitreous degeneration in normal dogs.     

Julien J Labruyère  Claudia Hartley  Katherine Rogers  Graham Wetherill  J Fraser McConnell  Ruth Dennis 《Veterinary radiology & ultrasound》2008,49(2):165-171

Vitreous degeneration is common in dogs and may be associated with cataract formation. Vitreous degeneration may be identified using B-mode ultrasonography and appears as multiple, small, motile, point-like echoes within the vitreous cavity. In humans, vitreous degeneration has also been observed in normal aging eyes but the incidence of vitreous degeneration in dogs without cataract has not previously been documented. The purpose of this study was to describe the ultrasonographic appearance of vitreous degeneration and to investigate its incidence in a population of dogs without cataract or other apparent eye disease. The eyes of 62 dogs were evaluated as part of a prospective study. All dogs underwent ophthalmological and ultrasonographic examinations and vitreal changes were graded on ultrasonography using a predetermined grading scheme. Vitreous degeneration was found in 20% (23/114) of the eyes on ultrasonographic examination but in only 8% (9/114) of eyes on direct ophthalmoscopy. Sensitivity and specificity of ophthalmoscopy using ultrasonography as a gold standard were respectively, 39% and 100%. Vitreal syneresis and asteroid hyalosis could be distinguished according to their ultrasonographic characteristics. The probability of having vitreous degeneration increased with the age of the dog (odds ratio = 6.7 for dogs of 7 + years compared with 0-6 years) and also increased in females compared with males (odds ratio = 3.6). Vitreous degeneration, especially mild vitreal syneresis, is not uncommon in normal dogs; it was shown to be an age-related condition and its significance should not be overinterpreted on ocular ultrasonography.  相似文献   

Effects of exercise on chondrocyte viability and subchondral bone sclerosis in the distal third metacarpal and metatarsal bones of young horses     

Dykgraaf S  Firth EC  Rogers CW  Kawcak CE 《Veterinary journal (London, England : 1997)》2008,178(1):53-61

The objective was to determine the effects of early exercise on the articular cartilage and subchondral bone at specific sites of the distal third metacarpal and metatarsal bones of 12 young Thoroughbred horses allowed free choice exercise at pasture. Six of the horses had additional controlled exercise 5 days per week from mean age of 21+/-20 days of age (range: 3-83 days) until 17.1 months of age. Confocal laser scanning microscopy was used to quantify viable and non-viable chondrocytes. Proteoglycan scoring and modified Mankin scoring was performed and subchondral bone mineral density measured by computed tomography. The number of viable chondrocytes was significantly greater in the conditioned group, which also had a higher Safranin O/Fast Green (SOFG) score than did the group which could exercise only at pasture. There was no difference in mean bone mineral density between groups, nor was there relationship between subchondral bone mineral density and chondrocyte viability. The apparent beneficial effects of early conditioning exercise may support the use of exercise to optimise development of articular cartilage in young individuals.  相似文献   

Growth curves from birth to weaning for Thoroughbred foals raised on pasture     

Morel PC  Bokor A  Rogers CW  Firth EC 《New Zealand veterinary journal》2007,55(6):319-325

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Outcome of lag-screw treatment of incomplete fractures of the frontal plane of the radial facet of the third carpal bone in horses     

Rutherford DJ  Bladon B  Rogers CW 《New Zealand veterinary journal》2007,55(2):94-99

AIM: To describe outcomes for horses diagnosed with incomplete, non-displaced fractures of the frontal plane of the radial facet (INFR) of the third carpal bone (C3) treated by placement of a lag screw across the fracture under arthroscopic guidance. METHODS: Horses (n=13) diagnosed with INFR and treated between December 1999 and January 2005 using a lag screw placed over the fracture were studied. For each case, five horses matched for sire, age and sex which were not known to have INFR were sought for comparison. Racing performance data were collected from a commercial online database. The racing performance of cases pre- and post-operatively, and of cases and matched horses in the post-operative period was compared. RESULTS: Sixteen INFR were found in the 13 horses. Radiographic evidence of healed fracture lines 2-4 months after surgery was seen in 11/16 (69%) fractures; 11/13 (85%) cases raced again after a median recovery period of 292 (range 149-681) days. Treatment was considered successful in 9/13 (69%) cases, which were still in training or had been retired for reasons other than lameness localised to the middle carpal joint at the end of the study period. Just 6/13 (46%) cases had raced prior to injury. The racing ability pre- and post-operatively of five cases was compared, three (60%) of which performed better post-operatively than they had before. There was no significant difference in racing longevity or ability post-operatively between patients and matched (control) horses. CONCLUSIONS: Post-operatively, there was little difference in the racing performance between horses diagnosed with INFR which had a lag screw placed across the fracture line and horses matched for sire, age and sex which were not known to have INFR. CLINICAL RELEVANCE: Horses which were diagnosed with INFR of C3 and had a lag screw placed across the fracture had a good prognosis for future racing performance.  相似文献   

Light,soil, and seedling characteristics associated with varying levels of competition in a red pine plantation     

Johnson  James E.  Lindow  Scott G.  Rogers  Robert 《New Forests》1998,15(1):23-36

Red pine (Pinus resinosa Ait.) seedlings growing under differing levels of competition were evaluated during the fifth growing season following planting, and placed into low, moderate, or high tree classes, as a function of levels of competing vegetation. Tree growth, moisture status, and nutrition were monitored over the growing season. Additionally, site characteristics such as soil temperature and moisture, inorganic nitrogen concentration, mineralized soil nitrogen, and light were measured. Red pine seedlings growing under low competition had an absolute volume growth increase of 795% over the seedlings growing under the heaviest competition. The associated relative volume growth increase during the fifth growing season was 44%. Discriminant analysis was used to describe three classes of trees representing low, moderate, and high levels of competition. Trees growing under low competition had longer and heavier needles, but generally lower nutrient concentrations. Pre-dawn plant moisture status did not vary among competition levels. Soil variables indicated that, in general, the trees growing under low competition occupied warmer, drier, and less fertile microsites, as inorganic soil N and mean monthly mineralized NO₃-N and NH₄>-N tended to be lower on these microsites. The suite of independent variables was effective in classifying the model data into three tree competition classes, with percent correct classifications of 92, 75, and 100 for low (tree class one), moderate (tree class two), and heavy (tree class three) competition, respectively.  相似文献   

Effects of glutamine supplementation of an amino acid-based purified diet on intestinal mucosal integrity in cats with methotrexate-induced enteritis.     

S L Marks  A K Cook  R Reader  P H Kass  A P Théon  C Greve  Q R Rogers 《American journal of veterinary research》1999,60(6):755-763

OBJECTIVE: To determine effects of glutamine-supplemented and glutamine-free amino acid-based purified diets, compared with a dry expanded diet, on intestinal structure and function in a model that used cats with methotrexate-induced enteritis. ANIMALS: 18 adult specific-pathogen-free cats. PROCEDURE: 12 cats were given intragastric feedings of an amino acid-based purified diet supplemented with glutamine (7% [wt:wt]) or an isonitrogenous amount of glycine and alanine; 6 cats consumed a dry expanded diet. After 21 days, cats received methotrexate (MTX; 11 mg/kg of body weight, IV). Intestinal permeability testing was performed immediately before and 66 hours after MTX administration. Celiotomy was performed 72 hours after MTX administration for aseptic removal of mesenteric lymph nodes, collection of full-thickness intestinal biopsy specimens, determination of intestinal cellular proliferation, and collection of aortic and portal venous blood samples for determination of arteriovenous amino acid concentrations across the intestine. RESULTS: Administration of MTX was associated with severe enterotoxicosis manifested as diarrhea (8/12 cats), vomiting (12/12), and positive results for bacterial culture of mesenteric lymph nodes (12/12) in cats receiving the purified diets, independent of glutamine supplementation. Diet did not affect villus tip length and villus surface area in the small intestine or cellular proliferation. Administration of MTX was associated with significantly increased intestinal permeability, which was not attenuated by glutamine supplementation. CONCLUSIONS: Feeding of a glutamine-supplemented amino acid-based purified diet was unable to preserve intestinal function in cats with MTX-induced enteritis. CLINICAL RELEVANCE: Intestinal morphologic alterations correlate poorly with intestinal function as measured by means of bacterial translocation and intestinal permeability.  相似文献   

Partial Purification of a Water-Extractable Rye (Secale cereale) Protein Capable of Improving the Quality of Wheat Bread     

J. A. Delcour  I. P. Van Haesendonck  G. Cleemput  D. E. Rogers  R. C. Hoseney 《Cereal Chemistry》1998,75(4):403-407

Rye water-soluble extracts contain a protein fraction that, when added at low concentrations to a straight-dough breadmaking recipe, significantly increased bread volume. Enrichment of the active component is possible by anion-exchange fractionation with diethylaminoethyl-cellulose (DEAE), by ammonium sulfate precipitation, or by using rye bran or shorts milling fractions as the starting material. The active material was not bound to DEAE-cellulose. With ammonium sulfate precipitation, the fractions obtained at 30, 40, and 50% saturation were active in straightdough baking experiments. Iso-electric focusing revealed that fractions active in breadmaking invariably contained alkaline protein fractions (pI > 7.5). Inactivation of enzyme material by boiling the water-soluble extract from rye destroyed all breadmaking activity. The activity of the bread improver was additive to that of potassium bromate but not to that of ascorbic acid. It was not counteracted by catalase, showing that it does not work by a mechanism involving the production of hydrogen peroxide. The extract was not able to overcome the detrimental effect on bread quality resulting from mixing dough in a nitrogen atmosphere.  相似文献   

Flat earth economics and site-specific crop management: how flat is flat?     

Andrew Rogers  Tiho Ancev  Brett Whelan 《Precision Agriculture》2016,17(1):108-120

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Disseminated candidiasis secondary to fungal and bacterial peritonitis in a young dog     

Catherine L. Rogers  DVM  DACVECC  ; Christopher Gibson  VMD  ; Susan L. Mitchell  DVM  DACVS  ; John H. Keating  DVM  DACVP    Elizabeth A. Rozanski  DVM  DACVIM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2009,19(2):193-198

Objective – To describe a severe case of bacterial sepsis and disseminated candidiasis in a previously healthy dog.
Case Summary – Fungal sepsis was identified in a 2-year-old dog following intestinal dehiscence 4 days after abdominal surgery. Septic peritonitis was identified at admission and evidence of dehiscence at the previous enterotomy site was found during an exploratory laparotomy. Both gram-positive cocci and Candida albicans were cultured from the abdominal cavity. Candida sp. was also subsequently cultured from a central venous catheter. Euthanasia was performed due to failure to respond to therapy. Fungal organisms, morphologically consistent with Candida spp., were found in the lungs and kidney on postmortem histopathologic examination indicating disseminated candidiasis.
New or Unique Information Provided – Candida peritonitis is a well-recognized entity in humans and contributes to morbidity and mortality in critically ill patients. Abdominal surgery, intestinal perforation, presence of central venous catheters, and administration of broad-spectrum antibiotics are all considered to be suspected risk factors. This report describes the first known case of systemic candidiasis occurring secondary to Candida peritonitis and bacterial sepsis in a critically ill dog.  相似文献