Serological responses of Australian horses using a commercial duplex indirect ELISA following vaccination against strangles     

CM El‐Hage  H Bannai  AK Wiethoelter  SM Firestone  CM Heislers  JL Allen  AS Waller  JR Gilkerson 《Australian veterinary journal》2019,97(7):220-224

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Effect of Manuka honey gel on the transforming growth factor β1 and β3 concentrations,bacterial counts and histomorphology of contaminated full‐thickness skin wounds in equine distal limbs          下载免费PDF全文

AS Bischofberger  CM Dart  N Horadagoda  NR Perkins  LB Jeffcott  CB Little  AJ Dart 《Australian veterinary journal》2016,94(1-2):27-34

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Clinical trial of efficacy of ivermectin pour‐on against gastrointestinal parasitic nematodes in silvopasturing horses     

I. FRANCISCO  J. A. SÁNCHEZ  F. J. CORTIÑAS  R. FRANCISCO  E. MOCHALES  M. ARIAS  P. MULA  J. L. SUÁREZ  P. MORRONDO  P. DÍEZ‐BAÑOS  R. SÁNCHEZ‐ANDRADE  A. PAZ‐SILVA 《Equine veterinary journal》2009,41(7):713-715

The aim of this study was to assess, by a clinical trial, the efficacy of an ivermectin‐based pour‐on treatment against gastrointestinal parasitic nematodes in naturally infected horses using 2 groups of mature indigenous Pura Raza Galega grazing mares. Faecal and blood samples were collected individually over a 21 week period. Faeces were analysed by the coprological flotation, sedimentation and migration techniques. Changes in circulating blood cells were monitored over the study period. The administration of the ivermectin suppressed the eggelimination of ascarids and pinworms throughout the study and no strongyle‐eggs were observed in the treatment group between the 3rd and 10th weeks. The numbers of red cells increased significantly after the anthelmintic therapy, and a statistical reduction in circulating leucocytes was recorded. No side effects were observed. The pour‐on ivermectin formulation was highly successful against gastrointestinal nematodes and appears to be a useful therapeutic routine for large groups of horses.  相似文献   

Alteration of T-cell functions by infection with HTLV-I or HTLV-II   总被引：18，自引：0，他引：18  

M Popovic  N Flomenberg  D J Volkman  D Mann  A S Fauci  B Dupont  R C Gallo 《Science (New York, N.Y.)》1984,226(4673):459-462

Two functionally different types of human T-cell clones, one with helper function and two with specific activity, were infected with different isolates of HTLV-I and HLTV-II. Both types of human T cells showed alterations in specific function after infection with either of the HTLV subgroups. Before HTLV infection, the T-cell clone with helper function proliferates and provides help to B cells only in the presence of both a specific soluble antigen (keyhole limpet hemocyanin) and histocompatible antigen-presenting cells. After HTLV infection, these cells respond with increased proliferation and indiscriminant stimulation of polyclonal immunoglobulin production by B cells, regardless of the histocompatibility of the antigen-presenting cells or the presence of the soluble antigen. Infection of the normal cytotoxic T-cell clones led to a dimunition or loss of the cytotoxic function. The results of these studies suggest some possible mechanisms for induction of immune deficiency and of polyclonal B-cell activation by viruses of the HTLV family.  相似文献   

The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4   总被引：116，自引：0，他引：116  

S M Schnittman  M C Psallidopoulos  H C Lane  L Thompson  M Baseler  F Massari  C H Fox  N P Salzman  A S Fauci 《Science (New York, N.Y.)》1989,245(4915):305-308

Human immunodeficiency virus type 1 (HIV-1) selectively infects cells expressing the CD4 molecule, resulting in substantial quantitative and qualitative defects in CD4+ T lymphocyte function in patients with acquired immunodeficiency syndrome (AIDS). However, only a very small number of cells in the peripheral blood of HIV-1-infected individuals are expressing virus at any given time. Previous studies have demonstrated that in vitro infection of CD4+ T cells with HIV-1 results in downregulation of CD4 expression such that CD4 protein is no longer detectable on the surface of the infected cells. In the present study, highly purified subpopulations of peripheral blood mononuclear cells (PBMCs) from AIDS patients were obtained and purified by fluorescence-automated cell sorting. They were examined with the methodologies of virus isolation by limiting dilution analysis, in situ hybridization, immunofluorescence, and gene amplification. Within PBMCs, HIV-1 was expressed in vivo predominantly in the T cell subpopulation which, in contrast to the in vitro observations, continued to express CD4. The precursor frequency of these HIV-1-expressing cells was about 1/1000 CD4+ T cells. The CD4+ T cell population contained HIV-1 DNA in all HIV-1-infected individuals studied and the frequency in AIDS patients was at least 1/100 cells. This high level of infection may be the primary cause for the progressive decline in number and function of CD4+ T cells in patients with AIDS.  相似文献   

Effects of the aqueous extracts of Zygophyllum fabago on the growth of Fusarium oxyosporum f. sp. melonis and Pythium aphanidermatum     

ELÍAS D. DANA  JUAN GARCÍA DE LOMAS  JOSÉ SÁNCHEZ 《Weed Biology and Management》2010,10(3):170-175

In this study, the effects of aqueous extracts from Zygophyllum fabago L. on two plant phytopathogenic fungal species (namely, Fusarium oxyosporum f. sp. melonis and Pythium aphanidermatum) were studied under laboratory conditions. The plant extracts (10% w/v) were prepared by using deionized water and fresh tissues. Dilutions (2, 4, 6, and 8% w/v) were obtained to test their effect on the mycelial growth of the phytopathogenic species. Additionally, the recovery of the fungi after their exposure to the Z. fabago extract was analyzed. The plant extracts inhibited the growth of F. oxyosporum and P. aphanidermatum (the maximum mean inhibition that was recorded with the 10% w/v extracts was 42.9% and 85.3%, respectively). A second series of experiments demonstrated the existence of residual effects in both species. The amount of residual inhibition by the 10% w/v extracts was 28.6% in F. oxyosporum and 53.8% in P. aphanidermatum. A dose–response was clearly observed in P. aphanidermatum, while an increase in extract concentration was not associated with a significantly greater reduction in the growth of F. oxyosporum. These findings give insights into the potential of Z. fabago as a growth inhibitor of F. oxyosporum and P. aphanidermatum, thus suggesting an interesting potential role for this common weed as a source of natural fungicides.  相似文献   

Andosols developed from non-volcanic materials in Galicia, NW Spain   总被引：3，自引：0，他引：3  

E. GARCIA-RODEJA  B. M. SILVA  F. MACÍAS 《European Journal of Soil Science》1987,38(4):573-591

A set of well-drained soils in Galicia, formed from gabbros, amphibolites and schists, with udic moisture and mesic temperature regimes, are studied. All but one of the surface horizons show an'exchange complex dominated by amorphous material'(ECDAM); consequently, most soils are classified as Andosols (FAO) or as different subgroups of Dystrandepts (Soil Taxonomy). The soils on gabbros and amphibolites frequently have'andic properties'so, following the ICOMAND proposals, five of the 12 soils studied may be characterized as Andisols. Many of the five soils have properties comparable to those of soils from volcanic areas, especially to those called'non-allophanic Andosols', which have an abundance of active-Al, mainly in the form of Al-humus complexes.  相似文献   

Infection and replication of HIV-1 in purified progenitor cells of normal human bone marrow   总被引：40，自引：0，他引：40  

T M Folks  S W Kessler  J M Orenstein  J S Justement  E S Jaffe  A S Fauci 《Science (New York, N.Y.)》1988,242(4880):919-922

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Anopheles gambiae genome: completing the malaria triad     

Aultman KS  Gottlieb M  Giovanni MY  Fauci AS 《Science (New York, N.Y.)》2002,298(5591):13

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Thermally Switchable Periodicities and Diffraction from Mesoscopically Ordered Materials     

JM Weissman  HB Sunkara  AS Tse  SA Asher 《Science (New York, N.Y.)》1996,274(5289):959-960

Two switchable, mesoscopically periodic materials were created by combining crystalline colloidal array (CCA) self-assembly with the temperature-induced volume phase transition of poly(N-isopropylacrylamide) (PNIPAM). Body-centered-cubic CCAs of hydrated, swollen PNIPAM particles Bragg-diffract infrared, visible, and ultraviolet light weakly, whereas arrays of compact shrunken particles diffract efficiently. A tunable diffracting array was also created by embedding a CCA of polystyrene spheres within a PNIPAM hydrogel that swells and contracts with temperature; thus the array lattice constant varies with temperature, and the diffracted wavelength was thermally tunable across the entire visible spectrum. These materials may find applications in many areas of optics and materials science.  相似文献